SDHA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDHA_DROME
• UniProt AC: Q94523
• Protein Name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
• Gene Name: SdhA
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 661
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders..
• Protein Sequence: MSGIMRVPSILAKNAVASMQRAAAVGVQRSYHITHGRQQASAANPDKISKQYPVVDHAYDAIVVGAGGAGLRAAFGLVAEGFRTAVITKLFPTRSHTIAAQGGINAALGNMEEDDWKWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELENYGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCAVADRTGHSLLHTLYGQSLSYDCNYFVEYFALDLIFEDGECRGVLALNLEDGTLHRFRAKNTVIATGGYGRAFFSCTSAHTCTGDGTAMVARQGLPSQDLEFVQFHPTGIYGAGCLITEGCRGEGGYLINGNGERFMERYAPVAKDLASRDVVSRSMTIEIMEGRGAGPEKDHVYLQLHHLPPKQLAERLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGVPTNYRGQVITIDKDGKDVIVPGLYAAGEAASSSVHGANRLGANSLLDLVVFGRACAKTIAELNKPGAPAPTLKENAGEASVANLDKLRHANGQITTADLRLKMQKTMQHHAAVFRDGPILQDGVNKMKEIYKQFKDIKVVDRSLIWNSDLVETLELQNLLANAQMTIVSAEARKESRGAHAREDFKVREDEYDFSKPLDGQQKKPMDQHWRKHTLSWVCNDNGDITLDYRNVIDTTLDNEVSTVPPAIRSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Tele-8alpha-FAD histidine	KLFPTRSHTIAAQGG ECCCCCCHHHHHCCC		-
96	Other	KLFPTRSHTIAAQGG ECCCCCCHHHHHCCC		-
176	Acetylation	AFGGQSLKFGKGGQA CCCCCCCEECCCCCC		21791702
332	Acetylation	ERYAPVAKDLASRDV HHHHHHHHHHHCCCC		21791702
423	Acetylation	GQVITIDKDGKDVIV CCEEEECCCCCEEEE		21791702
496	Ubiquitination	ASVANLDKLRHANGQ HHHCCHHHHHHCCCC		31113955
542	Acetylation	NKMKEIYKQFKDIKV HHHHHHHHHHCCCEE		21791702
606	Acetylation	EDEYDFSKPLDGQQK CCCCCCCCCCCCCCC		21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDHA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDHA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDHA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STC_DROME	stc	physical	14605208
MSS4_DROME	CG7787	physical	14605208
MT1_DROME	MtnA	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.