STC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STC_DROME
• UniProt AC: P40798
• Protein Name: Protein shuttle craft
• Gene Name: stc
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1106
• Subcellular Localization: Nucleus.
• Protein Description: Plays an essential role during the late stages of embryonic neurogenesis. May either fine-tune the guidance or the spatial maintenance of the migrating SNB and in nerve roots, which are composed of axons originating from distinct groups of motor neurons and may be required to either guide or maintain the position of these nerves along a direct and straight path to their ultimate targets in particular muscle fields. May play a role in egg chamber development and/or may confer essential maternal contributions to the early embryo..
• Protein Sequence: MAEYWQQLTNGAGEAGPGNESSAMADCNGGHESAAVGGSCNRHSNNNYVNFNQFIMQHNLGGGAPSNATSTMQHPVGSSYTNFSLGGGGGAFGLNPPVASASTSHFANVSHQSPNFYSQAMIPTYQNGDGIARVTVTSSYGSVNPSNSNFSSFYTPFGNNPFDFSASKLQASAPEFVPNFAKLSLEETPAAATTNGNSTASLETAINETRPRTLRAQEPAERGANNQCSNHNYERERERERDRDRDRERDRDRDRDRDRDRDRDRDRDSRPGNTRQQRRSDYRDDREDRYERSDRRRPQKQQRYDNHRSNKRRDDWNRNRDRINGFPRAVDDLDTSNESAHPSPEKQSQLQQISPRRGPPLPPADNEKLSQREKLVRDIEQRRLECLVCVEAIKSHQPTWSCRNCYHMLHLKCTITWASSSKSEVGWRCPACQNVLQDLPRDYLCFCGKLKNPPVSRTELAHSCGEVCCRIEGCSHACTLLCHPGPCPPCQANVVRSCGCGRSTKTMQCAMKEEVLCGEICDKLLNCGEHRCQAECHSGKCAACSEQVVQQCHCGKQERKVPCTRESQDKRTYSCKDSCGQPLPCGHHKCKDSCHAGSCRPCKLSPEQITSCPCGKMPVPAGQRSSCLDPIPTCEGICSRTLRCGKPAHPHQCGSKCHLGQCPPCPKQTGVKCRCGHMDQMIKCRQLCNRADDARCKRRCTKKRSCGKHKCNVECCIDIDHDCPLPCNRTLSCGKHKCDQPCHRGNCPPCYRSSFEELYCECGAEVIYPPVPCGTKKPICKLPCSRIHPCDHPPQHNCHSGPTCPPCMIFTTKLCHGNHELRKTIPCSQPNFSCGMACGKPLPCGGHKCIKPCHEGPCQSAGEICRQSCTKPRPTCGHKCAAACHEGACPETPCKELVEVQCECGNRKQNRSCQELAREHSRIATIQLASSMAEMSRGNYMELSEILAPAKKSNKTLDCNDECRLLERNRRLAAALSSGNSDTKQKCLTKYSEFVRGFAKKNPALTKSVYETLTDLVKLAKESKQRSRSHSFPTMNREKRQLVHELCEVFGIESVSYDKEPNRNVVATAHKDRCWFPATSIMEVLARESGQRRVPVPSNNAWGLKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
167	Phosphorylation	NPFDFSASKLQASAP CCCCCCHHHHHHCCC	32.47	21082442
172	Phosphorylation	SASKLQASAPEFVPN CHHHHHHCCCCCCCC	31.25	25749252
280	Phosphorylation	NTRQQRRSDYRDDRE CHHHHHHHHHHCCHH	40.98	22817900
335	Phosphorylation	RAVDDLDTSNESAHP CHHHCCCCCCCCCCC	40.52	25749252
336	Phosphorylation	AVDDLDTSNESAHPS HHHCCCCCCCCCCCC	37.96	25749252
339	Phosphorylation	DLDTSNESAHPSPEK CCCCCCCCCCCCHHH	35.81	25749252
343	Phosphorylation	SNESAHPSPEKQSQL CCCCCCCCHHHHHHH	35.51	22817900
354	Phosphorylation	QSQLQQISPRRGPPL HHHHHHCCCCCCCCC	14.17	21082442
930	Phosphorylation	IATIQLASSMAEMSR HHHHHHHHHHHHHHC	29.28	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NU214_DROME	Nup214	physical	14605208
NU153_DROME	Nup153	physical	14605208
NUP58_DROME	Nup58	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-335; SER-336; SER-339;SER-343 AND SER-354, AND MASS SPECTROMETRY.
PubMed: 18327897