NU214_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NU214_DROME
• UniProt AC: Q9W1X4
• Protein Name: Nuclear pore complex protein Nup214
• Gene Name: Nup214 {ECO:0000312|EMBL:AAF46928.2}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1711
• Subcellular Localization: Nucleus, nuclear pore complex . Nucleus membrane; Peripheral membrane protein; Cytoplasmic side .
• Protein Description: May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex including emb and phosphorylated Mad..
• Protein Sequence: MAQNAPDCEDTQDFQFKLHHKIVAFKKCGEPRSNVNLLAVSSSRGLLFAGSPTQPELKVIIVKDLVNAKSTAQQPQARLVPLPSIPNYIACSSDGNLLAVNHTQNGTSLLSIYAVLSFMTPDVRPVYNIRLAAEDHVHGVQLLWNPVLPNSLAVVLSNGALAMYALKEGGNFEMHSLDKNQQVKCGCWSPKGKQIVLGFPGGTVKQFKPDLTLAKTLLCPPNIHDAPFDTIAIQWLSTFQFAVIFLQHGEDCSPSLYILNAPKAGAPSYINYYDICYSMNGPRNHQFVFSHVPQWNLLLVVSANGVEVGIMRSTEAGDTPAWQQLTLLDEARIEMPLSEDKDETFPLGFAFDTSTTHQLTINEKKLQTMPMVHVLSSDGELLSFNFLNVLPTAVSVCSPPPPVADTSGQFKPLNMLLASEEEEQPAWAASPSKAPAATPAASSDISFAFTPNTVTSTPAPSKDKQPSLFSGFGAAAAKAPAPQLSFGTAPTSSPVSFGAPTTNAAKPTTPFGGFGTQATTTAMGSMFSASGANAFGGMALNKPAIASVTPRTAAPGSTVPATPASAPANKPLYTVPLTFTPVDTKPATSAPPQIADESLKPDDTEPIIKDMIALQIEAFSKDIQKQKEQTKELLKGIAAPSALRAYAKRLDDLQELNEQAKDVEFELDVQGLRQGLNEAYAIVAECRGKLEIYRKPEITRLMNSSSCDPSGRRMLARLQSYVAANEAQLRLAQQHVDLQWEQFQDVVRRNSKSRMHMPCLEGIYQRLTRLQNLTSNQRIVQNNIKSKLKERGLLQAALLDQEKSRTRTNEAVDTLTDSILTMSLSQVVDSNAAKLTRERLQKIRNIVQLQKINVICPQRPDRVGLKSEVILETKRRAEQIKRAAAKPATANKYTQAAVAPPSPPDVAPTPAVAPMPQATVTVAPPLPKPMPSIPSVVEKPGVPTHPTTPVATPFSFSQSIPFVKTSTVTPTTNTVTPGEAAKPGLSIFGGSTISSFSFGGGAAKSALSFGTGSPAVAAPTPKPNPLSAVEKPTPEPTKPKEQKAAESKEFKAVQPETEESKVPQKPKAETENKSFGFGGFTGTGGTVGNTSSSPFSFGGLGSSLGFGGTAAAVPKSEPSSTATTSVATSASTAPFGIFSAALAKPSNSEPITTVTSNTTTITSKPTNVIASSSVTDAPSVTTTNAVTSSTDPIGGLFSSVTICKPNTPADTTKPANIFGGGLSAGSFSFGGTIDASKGLFGSTKPVATAPTSVTEANNKTDPISTTPSAISTTTATTTVSSPAVVPAAVTAAVPATSSTTVTSSTAVPGSAFSFSNAFSTLSAGGAAAPTTSASAPLAAKSPTATSTGNNSSNSVFGGGFAVATSTAAPVASPFQSAAKSPVSSANIFGSIPKAETSVFGGATTAPSNTTAAATPDAPPAGLFASAAISNPSPFGSPTTRAPASGGNIFGQAVKPSVFGQPAQAGDSGGSIFGGGSASTPFGSSSIFGGGNTQGAVGAPAAGSTSIFGQKVFGQSSAAAPAAGGNIFSNPVGSPQASPFGGGGNSIFGSPATAPPASGGSIFGGGSSSGGFGSFTQTTPAQGGFGGGFGQGGGGSVAQTGFGSPQAPQQQTTTPGGFGAKPVFGGSPAFGASPTFGGGATFGSPKGFGGFGGASPVASPPPFGAAAKPAQGNIFETLGGQESGLSFGNLAQTGNSNAQKPAFGGSSFMNYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
208	Acetylation	GGTVKQFKPDLTLAK CCCCHHCCCCCEEEH	34.82	21791702
438	Phosphorylation	PSKAPAATPAASSDI CCCCCCCCCCCCCCC	18.63	21082442
442	Phosphorylation	PAATPAASSDISFAF CCCCCCCCCCCEEEE	30.56	21082442
467	Phosphorylation	PSKDKQPSLFSGFGA CCCCCCCCHHCCCCH	39.28	21082442
493	Phosphorylation	FGTAPTSSPVSFGAP CCCCCCCCCCCCCCC	31.62	21082442
562	Phosphorylation	PGSTVPATPASAPAN CCCCCCCCCCCCCCC	17.20	19429919
565	Phosphorylation	TVPATPASAPANKPL CCCCCCCCCCCCCCC	35.67	19429919
578	Phosphorylation	PLYTVPLTFTPVDTK CCEEEEEEEEECCCC	21.28	19429919
580	Phosphorylation	YTVPLTFTPVDTKPA EEEEEEEEECCCCCC	19.71	19429919
720	Phosphorylation	RMLARLQSYVAANEA HHHHHHHHHHHHCHH	26.60	21082442
804	Phosphorylation	ALLDQEKSRTRTNEA HHHCHHHHCHHCHHH	37.82	22817900
932	Phosphorylation	PLPKPMPSIPSVVEK CCCCCCCCCCCCCCC	40.66	21082442
935	Phosphorylation	KPMPSIPSVVEKPGV CCCCCCCCCCCCCCC	36.81	21082442
944	Phosphorylation	VEKPGVPTHPTTPVA CCCCCCCCCCCCCCC	37.77	19429919
947	Phosphorylation	PGVPTHPTTPVATPF CCCCCCCCCCCCCCC	35.81	19429919
948	Phosphorylation	GVPTHPTTPVATPFS CCCCCCCCCCCCCCC	21.88	19429919
952	Phosphorylation	HPTTPVATPFSFSQS CCCCCCCCCCCCCCC	25.71	19429919
1013	Phosphorylation	ALSFGTGSPAVAAPT HHHCCCCCCCCCCCC	14.99	21082442
1632	Phosphorylation	GSPAFGASPTFGGGA CCCCCCCCCCCCCCC	25.50	21082442
1640	Phosphorylation	PTFGGGATFGSPKGF CCCCCCCCCCCCCCC	31.63	23607784
1643	Phosphorylation	GGGATFGSPKGFGGF CCCCCCCCCCCCCCC	21.17	19429919
1654	Phosphorylation	FGGFGGASPVASPPP CCCCCCCCCCCCCCC	24.15	19429919
1658	Phosphorylation	GGASPVASPPPFGAA CCCCCCCCCCCCCCC	37.87	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NU214_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NU214_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NU214_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP88_DROME	mbo	physical	14638854
NUP88_DROME	mbo	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.