NUP88_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUP88_DROME
• UniProt AC: Q9GYU8
• Protein Name: Nuclear pore complex protein Nup88
• Gene Name: mbo {ECO:0000312|EMBL:AAF98552.1}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 702
• Subcellular Localization: Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side . Chromosome . Nucleus, nucleoplasm . Is recruited to non-active chromatin sites.
• Protein Description: Essential component of nuclear pore complex. Selectively required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response. [PubMed: 10921908 Required for the anchoring of Nup214 and emb on the nuclear envelope and thereby attenuates nuclear export signal (NES)-mediated nuclear export]
• Protein Sequence: MSLTDVLELNKTELFAKIRNGLPVVQRTQNLLDCKDDLLFAWHAKDSCLLVRNWRSSLAAKVNIQFQTLIPSSLVSLEVDRVLASNEGSLVALSGPRGVVIMELPRRWGPDGYYKDGKPVITCRTFGLDTQLFLKNPHLEVRQVRWHPHSVSDSTLLVLLNNNTIRVYNHSKLRHVWQVGPPVLRSGANNSLCDFGELAVDFDIAPAAKPRVTEPETAGNNETTLDKSNKTLVAAKSLPKQERIEWPMVVLRENGNIYILMTGVDSENTRLQGPVTITPQAHDNYGLESCALMIIPSLPPTIVIAESNGKLHHALLMEAEATEHSFNEVDDSVLIEPAEYVVHVLETVELELGISAPATGKEGGNCPIYLKRDLINELRYFAYHNAGLHAVTVSFIAELQRYLESESDEDRLELAVSASAEYILCTKFDSSETVNAVFGLALLQIPAGIVLLLGSGQVISLKLVIDAQLLVTPNENKPVDSEVSQQESGPPFVDTIKSLLQRSVNQPILADKLSSPSAQESFELLNQAIEVLREQYLKRHDLVRAAFTRHINQIQLKKEQQLQEIQDLEQERELISERAHKLAERFEEISYNQELLVRKCNALMQRANASLPNSVIAEREFSQEVIRLNKVTQSLAAGLETAKKTFNKQRYHIAQSQEDLKKNAYELPEKQHRTITEILTQLTGEIDRQITDVKRINKIVGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
191	Phosphorylation	LRSGANNSLCDFGEL CCCCCCCCCCCHHHC	30.13	22817900
224	Phosphorylation	TAGNNETTLDKSNKT CCCCCCCCCCCCCCE	27.12	22817900
228	Phosphorylation	NETTLDKSNKTLVAA CCCCCCCCCCEEEEE	43.13	22817900
231	Phosphorylation	TLDKSNKTLVAAKSL CCCCCCCEEEEEECC	30.62	22817900
503	Phosphorylation	IKSLLQRSVNQPILA HHHHHHHHCCCCCHH	16.68	22817900
656	Phosphorylation	QRYHIAQSQEDLKKN HHHHHHCCHHHHHHC	26.90	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUP88_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUP88_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUP88_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCD22_DROME	CG9951	physical	14605208
DTBP1_DROME	Dysb	physical	14605208
MED4_DROME	MED4	physical	14605208
XPO1_DROME	emb	physical	14638854

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191; SER-228 ANDTHR-231, AND MASS SPECTROMETRY.
PubMed: 18327897