dbPTM

VLS_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VLS_DROME
UniProt AC	Q9VIP8
Protein Name	Protein valois
Gene Name	vls
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	367
Subcellular Localization	Cytoplasm .
Protein Description	Involved in specific localization of cytoplasmic proteins during the formation of pole plasm. Required for synthesis and/or stability of oskar protein (osk) and localization of tudor (tud) in both the nuage and posterior pole of the oocyte. Required for normal posterior localization of osk in later stages of oogenesis and for posterior localization of the vasa (vas) protein during the entire process of pole plasm assembly. May act by regulating the complex that contains the arginine N-methyltransferase csul..
Protein Sequence	MFPQRSSELYRTPVTHQPPPALELAGNLEYPNLNIADLNARLENLSPRLHDCWDSIAINDHNHLALATNRREGRQWWGMLFGYGRDQMHHMSVDSANFKLQAEHTVNIVRYAEDDFLLVALGDTRLQAWSTYSKVRDSQSPYCLFLVGESSAHPTPISQLSVFKADPRTAVSGSADSTLNVWDLSGADMVSTYRSRSSHTDKLTGLATPAASVDKFVTCDRGGCARLWDVRAAAPSSTCLYADASHVLSFTSAAWAAASELQGDNHIYLGDYDGKVHTLDIRVPRKLAETREYFDKGHVAQLLINGPHLAAMSNLPASVKVANVQAGHEFIYTHQDTHSRLTDAVWTDDSTLITIGHGRKMVTHAIK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
46	Phosphorylation	NARLENLSPRLHDCW HHHHHHCCCCHHHHH	21.40	19429919
138	Phosphorylation	TYSKVRDSQSPYCLF CCHHHCCCCCCEEEE	23.22	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VLS_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VLS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VLS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DIMM_DROME	dimm	physical	14605208
NANOS_DROME	nos	genetic	1908748
OSKA_DROME	osk	physical	21179512

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VLS_DROME

Related Literatures of Post-Translational Modification