RB27C_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RB27C_DROME
• UniProt AC: P48809
• Protein Name: Heterogeneous nuclear ribonucleoprotein 27C
• Gene Name: Hrb27C
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 421
• Subcellular Localization: Nucleus. Cytoplasm. Nuclear and/or cytoplasmic.
• Protein Description: This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle..
• Protein Sequence: MEEDERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQNGPHTLDGRTIDPKPCNPRTLQKPKKGGGYKVFLGGLPSNVTETDLRTFFNRYGKVTEVVIMYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRDGSGGQNSNNSTVGGAYGKLGNECSHWGPHHAPINMMQGQNGQMGGPPLNMPIGAPNMMPGYQGWGTSPQQQQYGYGNSGPGSYQGWGAPPGPQGPPPQWSNYAGPQQTQGYGGYDMYNSTSTGAPSGPSGGGSWNSWNMPPNSAGPTGAPGAGAGTATDMYSRAQAWATGGPSTTGPVGGMPRTGPGNSASKSGSEYDYGGYGSGYDYDYSNYVKQEGASNYGAGPRSAYGNDSSTQPPYATSQAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
177	Phosphorylation	KAEPRDGSGGQNSNN ECCCCCCCCCCCCCC	44.00	22817900
182	Phosphorylation	DGSGGQNSNNSTVGG CCCCCCCCCCCCCCC	29.51	19429919
185	Phosphorylation	GGQNSNNSTVGGAYG CCCCCCCCCCCCCHH	28.81	19429919
186	Phosphorylation	GQNSNNSTVGGAYGK CCCCCCCCCCCCHHC	25.87	19429919
191	Phosphorylation	NSTVGGAYGKLGNEC CCCCCCCHHCCCCCC	20.33	18281928
348	Phosphorylation	AWATGGPSTTGPVGG HHHCCCCCCCCCCCC	41.71	21082442
359	Phosphorylation	PVGGMPRTGPGNSAS CCCCCCCCCCCCCCC	41.69	21082442
364	Phosphorylation	PRTGPGNSASKSGSE CCCCCCCCCCCCCCC	39.57	19429919
366	Phosphorylation	TGPGNSASKSGSEYD CCCCCCCCCCCCCCC	27.46	19429919
368	Phosphorylation	PGNSASKSGSEYDYG CCCCCCCCCCCCCCC	45.09	19429919
370	Phosphorylation	NSASKSGSEYDYGGY CCCCCCCCCCCCCCC	39.82	19429919
372	Phosphorylation	ASKSGSEYDYGGYGS CCCCCCCCCCCCCCC	19.03	22817900
374	Phosphorylation	KSGSEYDYGGYGSGY CCCCCCCCCCCCCCC	16.14	20450229
377	Phosphorylation	SEYDYGGYGSGYDYD CCCCCCCCCCCCCCC	12.07	20450229
379	Phosphorylation	YDYGGYGSGYDYDYS CCCCCCCCCCCCCHH	26.20	19429919
397	Phosphorylation	KQEGASNYGAGPRSA CCCCCCCCCCCCCCC	13.07	25749252
403	Phosphorylation	NYGAGPRSAYGNDSS CCCCCCCCCCCCCCC	29.04	19429919
405	Phosphorylation	GAGPRSAYGNDSSTQ CCCCCCCCCCCCCCC	20.08	19429919
415	Phosphorylation	DSSTQPPYATSQAV- CCCCCCCCCCCCCC-	29.24	18281928

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RB27C_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RB27C_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RB27C_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RB97D_DROME	Rb97D	physical	14605208
Y2199_DROME	CG2199	physical	14605208
K10_DROME	fs(1)K10	physical	14605208
CTBP_DROME	CtBP	physical	14605208
PROML_DROME	prominin-like	physical	14605208
FER_DROME	FER	physical	14605208
OTU_DROME	otu	genetic	15056611
CUP_DROME	cup	physical	18082158
GRK_DROME	grk	physical	15056611
PABP_DROME	pAbp	physical	18082158
OSKA_DROME	osk	physical	15056611
ROA1_DROME	Hrb98DE	physical	26545814
RB87F_DROME	Hrb87F	physical	26545814

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177; SER-366; SER-368;SER-370; TYR-372 AND SER-379, AND MASS SPECTROMETRY.
PubMed: 18327897