PROML_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PROML_DROME
• UniProt AC: P82295
• Protein Name: Prominin-like protein
• Gene Name: prominin-like
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1013
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MGEVAATVEPLAAVKSKSMRSRKRRQRRRRQIAYLAICGLSVAIFGFALATLIRPTTAQADADPGSWRKGYVGHGTTHEQLGQPHWPPVQYTVYRPTTNYTKAPPPPTSAMNPIFNFTHFLYDKVLYRDEPIPEGYIVVKNSDTLSLGPKVEENDWRDLLAHYWMVLIWVVILVVLIIVIPFIAVCYCCFCCCRRCRQGCPPCTSKQDAQRRFCCGICLLILIIGLIFGIIIAFVTNKMIDSGFAETSETMKRGSEDTCTYLKDVADHVHHLMMYNYEEMETHVLDQLTHAHRHIFLDLSDTSESNSLAEMERVLENMPEALELMRQVEKMEKDLRFYGSQLRDGVRGIKRDVNFAVANLCQLQMCQKFLISSNIEHIDSSQCLHFDNLPNTKEFVEGMENIVASEYYAIPQRGLSRLKKVSDKVKTQLSFVVPPMMRDLTKGRTIFREHATNVRNIVEGVLSDIHIKTLHSTKSFEDVYERFGHDRNVVSLIVCLLILLVLFILIFALLCGCFGRRRTGYGDECCSKSTGATCLLLAILLIFCVFSFIALVGLFYFMLGMVTYQGACAPLRDQENNTLFRQLDASIDLNHYLPPSESNKEVVQPLKMSSAIKACHANQTIFDMMRQHNIYDINDLTRIKVMSHSQENTDSIKVFDEDLSTVVLLTKEERDELKTAGESKLAKYHSSLYMPSLCTQFTPMNLNALSEQLYKLSNDLEYPAYGWAKVSFWNEGLNTKAFYRNFVPKLTSLVEKMKANLKKIDELISYENHDFTNTIKILTATAINSEQFIQTRGKDYINALGGNLTNSIDQMIDDYIDMIIKEANESVGHCAPLSYIYYRGVDLICHRIVDPINGFWVGILLCALLFLPILFVAHRLMCLYKKIYPYLATVGAAGVVEGGSDYLYDAYSERDREHVPLANVPKKRRKAYERRREQQDYFEDASPSVSRGNRSGGDRGGGGGDGAPGSSSMRYNDMAPTHWDHEPPRYHNPPAAPPSSEYERPPPYYYPGASEQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	N-linked_Glycosylation	TVYRPTTNYTKAPPP EEECCCCCCCCCCCC	44.98	19349973
116	N-linked_Glycosylation	SAMNPIFNFTHFLYD CCCCCCCCHHHHHHC	41.44	-
576	N-linked_Glycosylation	APLRDQENNTLFRQL CCCCCCCCCCHHHHH	40.95	19349973
618	N-linked_Glycosylation	AIKACHANQTIFDMM HHHHHHCCCHHHHHH	18.83	-
803	N-linked_Glycosylation	YINALGGNLTNSIDQ HHHHCCCHHCHHHHH	41.72	-
824	N-linked_Glycosylation	DMIIKEANESVGHCA HHHHHHHHHCCCCCC	43.07	-
937	Phosphorylation	RRREQQDYFEDASPS HHHHHHHHHCCCCCC	12.44	18281928
942	Phosphorylation	QDYFEDASPSVSRGN HHHHCCCCCCCCCCC	29.99	25749252
949	N-linked_Glycosylation	SPSVSRGNRSGGDRG CCCCCCCCCCCCCCC	33.56	-
968	Phosphorylation	DGAPGSSSMRYNDMA CCCCCCCCCCCCCCC	14.69	27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PROML_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PROML_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PROML_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of PROML_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-99 AND ASN-576, AND MASSSPECTROMETRY.
PubMed: 19349973