1433Z_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1433Z_DROME
• UniProt AC: P29310
• Protein Name: 14-3-3 protein zeta
• Gene Name: 14-3-3zeta
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 248
• Subcellular Localization: Cytoplasm. Early endosome .
• Protein Description: Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. [PubMed: 9159395 Acts upstream of Raf and downstream of Ras, and is essential for viability]
• Protein Sequence: MSTVDKEELVQKAKLAEQSERYDDMAQAMKSVTETGVELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEASARKQQLAREYRERVEKELREICYEVLGLLDKYLIPKASNPESKVFYLKMKGDYYRYLAEVATGDARNTVVDDSQTAYQDAFDISKGKMQPTHPIRLGLALNFSVFYYEILNSPDKACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDTQGDEAEPQEGGDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTVDKEEL ------CCCCCHHHH	36.82	19429919
3	Phosphorylation	-----MSTVDKEELV -----CCCCCHHHHH	31.27	19429919
48	Phosphorylation	NEERNLLSVAYKNVV HHHHHHHHHHHHHHH	14.10	19429919
51	Phosphorylation	RNLLSVAYKNVVGAR HHHHHHHHHHHHCCC	10.84	19429919
52	Acetylation	NLLSVAYKNVVGARR HHHHHHHHHHHCCCH	33.26	21791702
71	Acetylation	VISSIEQKTEASARK HHHHHHHHHHHHHHH	35.23	21791702
85	Nitration	KQQLAREYRERVEKE HHHHHHHHHHHHHHH	16.54	-
111	Acetylation	LDKYLIPKASNPESK HHHHHCCCCCCCCCC	58.41	21791702
118	Acetylation	KASNPESKVFYLKMK CCCCCCCCEEEEEEC	34.40	21791702
123	Acetylation	ESKVFYLKMKGDYYR CCCEEEEEECCHHHH	27.47	21791702
213	Phosphorylation	LDTLNEDSYKDSTLI HHCCCCCCCCCHHHH	28.09	19429919
232	Phosphorylation	RDNLTLWTSDTQGDE HHCCEEEECCCCCCC	21.60	19429919
233	Phosphorylation	DNLTLWTSDTQGDEA HCCEEEECCCCCCCC	27.38	19429919
235	Phosphorylation	LTLWTSDTQGDEAEP CEEEECCCCCCCCCC	33.93	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 1433Z_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1433Z_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1433Z_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VA0D1_DROME	VhaAC39-1	physical	14605208
STX1A_DROME	Syx1A	physical	14605208
MON2_DROME	mon2	physical	14605208
CSW_DROME	csw	physical	14605208
RNK_DROME	CG40127	physical	14605208
FTZF1_DROME	ftz-f1	physical	14605208
RLA1_DROME	RpLP1	physical	14605208
SLOB_DROME	Slob	physical	10230800
SLO_DROME	slo	physical	10230800
BOREA_DROME	borr	physical	22036573
TNG2_DROME	Tango2	physical	22036573
RS27A_DROME	RpS27A	physical	24292889
RHEB_DROME	Rheb	physical	27151460
ELP3_DROME	Elp3	physical	20532201
1433Z_DROME	14-3-3zeta	physical	19920133
1433Z_DROME	14-3-3zeta	physical	24147113
YAP1_DROME	yki	physical	26887950
TCTP_DROME	Tctp	physical	27151460
1433E_DROME	14-3-3epsilon	physical	19920133
1433E_DROME	14-3-3epsilon	physical	23987511

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.