STX1A_DROME - dbPTM
STX1A_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STX1A_DROME
UniProt AC Q24547
Protein Name Syntaxin-1A
Gene Name Syx1A
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 291
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Single-pass type IV membrane protein . Lysosome membrane
Single-pass type IV membrane protein .
Protein Description Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. [PubMed: 7834751 Essential for embryonic viability and development]
Protein Sequence MTKDRLAALHAAQSDDEEETEVAVNVDGHDSYMDDFFAQVEEIRGMIDKVQDNVEEVKKKHSAILSAPQTDEKTKQELEDLMADIKKNANRVRGKLKGIEQNIEQEEQQNKSSADLRIRKTQHSTLSRKFVEVMTEYNRTQTDYRERCKGRIQRQLEITGRPTNDDELEKMLEEGNSSVFTQGIIMETQQAKQTLADIEARHQDIMKLETSIKELHDMFMDMAMLVESQGEMIDRIEYHVEHAMDYVQTATQDTKKALKYQSKARRKKIMILICLTVLGILAASYVSSYFM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationAALHAAQSDDEEETE
HHHHHHCCCCCCCCC		42.1623607784
20PhosphorylationQSDDEEETEVAVNVD
CCCCCCCCCEEEECC		38.7523607784
70PhosphorylationAILSAPQTDEKTKQE
HHHCCCCCCHHHHHH		45.1018327897
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STX1A_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STX1A_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STX1A_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNAP_DROMEalphaSnapphysical
14605208
SLY1_DROMESlhphysical
22036573
SNAP_DROMEalphaSnapphysical
22036573
USE1_DROMEUse1physical
22036573
GOSR2_DROMEMembrinphysical
22036573
GOSR1_DROMEGos28physical
22036573
NSF2_DROMENsf2physical
22036573
POK_DROMEaopgenetic
15687281
GMDS_DROMEGmdgenetic
15687281
SMRCD_DROMEEtl1genetic
15687281
ACT2_DROMEAct42Agenetic
15687281
EFR3_DROMEstmAgenetic
16510714
PDK_DROMEPdkgenetic
15687281
RS23_DROMERpS23genetic
15687281
CDV3_DROMECG3760genetic
15687281
DNJC5_DROMECspgenetic
10575024
SEPT1_DROMESep1physical
17456438
SY65_DROMESyt1physical
20688915
SY65_DROMESyt1physical
21307261
SNP25_DROMESnap25physical
21316453
SNP25_DROMESnap25physical
20688915
PNUT_DROMEpnutphysical
17456438
SNAP_DROMEalphaSnapphysical
21316453
NSF1_DROMEcomtphysical
21316453
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STX1A_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-70, AND MASSSPECTROMETRY.

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