SY65_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SY65_DROME
• UniProt AC: P21521
• Protein Name: Synaptotagmin 1
• Gene Name: Syt1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 474
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein . Cell junction, synapse . Synaptic vesicles in neurons.
• Protein Description: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone..
• Protein Sequence: MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEILKNMK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
156	Phosphorylation	KKGVDMKSVQLLGSA CCCCCHHHHHHHHHH	14.41	27794539
156 (in isoform 2)	Phosphorylation	-	14.41	27794539
162	Phosphorylation	KSVQLLGSAYKEKVQ HHHHHHHHHHHHHCC	28.52	28490779
162 (in isoform 2)	Phosphorylation	-	28.52	27794539
174 (in isoform 2)	Phosphorylation	-	55.12	27794539
176	Phosphorylation	QPDMEELTENAEEGD CCCHHHHHHCHHHCC	30.39	27794539
189	Phosphorylation	GDEEDKQSEQKLGRL CCHHHHHHHHHHHCC	47.97	27794539
254	Phosphorylation	KVHRKTLSPVFNETF HHCHHCCCHHHCCCC	25.01	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SY65_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SY65_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SY65_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SY65_DROME	Syt1	physical	23283333
SNP25_DROME	Snap25	physical	20688915
KLC_DROME	Klc	physical	24086147

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.