| UniProt ID | SMRCD_DROME | |
|---|---|---|
| UniProt AC | Q9VL72 | |
| Protein Name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog | |
| Gene Name | Etl1 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 844 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity).. | |
| Protein Sequence | MSDSTVAASASASASSSAKSSLSDLRQFRINKNASSVVASPSRTERVPGKKRIQVMADSDSDGNDSQTPKKTKLELTVKEKEERYMAAAKISPHFDTMAIQESLSRTNWDVAASVRYLRENCKPKGHNGPLAKSKLKPRSNGISGGNFSDNDHSDDDDVKQSKDQVYDSDDSDSEMSTKMTGQRKKVFQFMNEASLIELQSVKTLSEKKALAIIDVRPFSDWSDLRQKLESIRMSGDLLNYAQELINKQNTVAAILSKCNNMVSRLEKAISNGAGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRRMRGRFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELVDYYSNNKGEVCSSSERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLANASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDSIFVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLEKDITSNEKGEVHEQRCVVKLLTTALGLDKDQEEQLNNSLNNSIASPAK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 59 | Phosphorylation | RIQVMADSDSDGNDS EEEEEECCCCCCCCC | 19429919 | ||
| 61 | Phosphorylation | QVMADSDSDGNDSQT EEEECCCCCCCCCCC | 19429919 | ||
| 66 | Phosphorylation | SDSDGNDSQTPKKTK CCCCCCCCCCCCCCE | 23607784 | ||
| 68 | Phosphorylation | SDGNDSQTPKKTKLE CCCCCCCCCCCCEEE | 23607784 | ||
| 92 | Phosphorylation | YMAAAKISPHFDTMA HHHHHCCCCCHHHHH | 22817900 | ||
| 144 | Phosphorylation | KPRSNGISGGNFSDN CCCCCCCCCCCCCCC | 29892262 | ||
| 149 | Phosphorylation | GISGGNFSDNDHSDD CCCCCCCCCCCCCCC | 19429919 | ||
| 154 | Phosphorylation | NFSDNDHSDDDDVKQ CCCCCCCCCCCCCHH | 19429919 | ||
| 167 | Phosphorylation | KQSKDQVYDSDDSDS HHHHHHCCCCCCCCC | 29892262 | ||
| 169 | Phosphorylation | SKDQVYDSDDSDSEM HHHHCCCCCCCCCHH | 19429919 | ||
| 172 | Phosphorylation | QVYDSDDSDSEMSTK HCCCCCCCCCHHHHH | 19429919 | ||
| 475 | Acetylation | VMPKFFAKSIEDIKS HHHHHHHHCHHHHHH | 21791702 | ||
| 834 | Phosphorylation | QEEQLNNSLNNSIAS HHHHHHHHHHHHCCC | 22817900 | ||
| 838 | Phosphorylation | LNNSLNNSIASPAK- HHHHHHHHCCCCCC- | 22817900 | ||
| 841 | Phosphorylation | SLNNSIASPAK---- HHHHHCCCCCC---- | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SMRCD_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SMRCD_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SMRCD_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SMRCD_DROME !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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