NSF1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSF1_DROME
• UniProt AC: P46461
• Protein Name: Vesicle-fusing ATPase 1
• Gene Name: comt
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 745
• Subcellular Localization: Cytoplasm.
• Protein Description: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin..
• Protein Sequence: MAYILKATKCPTDELSLTNRAIVNVGDFPEEIKYADISPAPGQHFIFALEKTVEVPSGYVGFSLVQRKWAMVSINQELEVRPYRFDASSDVITCVSFETDFLQKKTVSQEPYDSDQMAKEFIMQFAGMALTVGQSLVFNFKDKKLLGLAVKSLEAIDPKSLGEGKDTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSIFRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHDTVVNQLLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFNKINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFLHSLEHDIKPAFGTAQEILDNMLARGVINWGAPVSNLLEDGMLYVQQAKAPESSGLVSVLVAGAPNSGKTALAAQLAKMSDFPFVKVCSPEDMVGYTESAKCLHIRKIFDDAYRSMLSCIVVDNVERLLDYGSIGPRYSNMTLQALLVLLKKQPPKGRKLLILCTSSRREVLEEMEMLTAFTSVLHVPNLSKPDHVLAVLENTDIFSKGEIQAIGKKMAGKRVFIGIKKLLGLIDMARQTEQSQRAIKFLSKMEEEGGLDMVARQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	EIKYADISPAPGQHF HCCCCCCCCCCCCEE	18.63	22817900
207	Phosphorylation	KGKVVRQSIINPDWD CCCEEEEECCCCCCC	18.18	19429919
339	Phosphorylation	AICKQRGSVAGNSGV HHHHHCCCCCCCCCC	15.81	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSF1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAD2A_DROME	Ada2a	physical	14605208
CAC1A_DROME	cac	genetic	10790395
SNAP_DROME	alphaSnap	genetic	25519897
NSF2_DROME	Nsf2	genetic	11333235
DYN_DROME	shi	genetic	11593041
SNAP_DROME	alphaSnap	physical	21316453

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.