CAC1A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAC1A_DROME
• UniProt AC: P91645
• Protein Name: Voltage-dependent calcium channel type A subunit alpha-1
• Gene Name: cac
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1851
• Subcellular Localization: Membrane ; Multi-pass membrane protein.
• Protein Description: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine-insensitive current. Vital for survival to adulthood..
• Protein Sequence: MGGPKKEENPPGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFSNERNRVERRMEFQKCRFRAMFQTAMVSYLDWITQAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGHDDSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDREREVERERLEYIAPLSFEQALAMGRTGRVLPSPVLNGFKPKSGLNPRHSDSDEEDWC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
234	N-linked_Glycosylation	ATGSFVCNNTTSMCL HCCCEEECCCCHHCC	43.51	-
235	N-linked_Glycosylation	TGSFVCNNTTSMCLE CCCEEECCCCHHCCH	39.34	-
865	N-linked_Glycosylation	SGSSAGQNLSTIKSL CCCCCCCCHHHHHHH	34.73	-
1348	Phosphorylation	DYLTRDSSILGAHHL HHHCCCCCHHCCCCH	26.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAC1A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAC1A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAC1A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCNA_DROME	para	genetic	26771829
MLE_DROME	mle	genetic	9504928
DAB_DROME	Dab	genetic	21606364
NSF1_DROME	comt	genetic	10790395

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.