MLE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLE_DROME
• UniProt AC: P24785
• Protein Name: Dosage compensation regulator
• Gene Name: mle {ECO:0000312|FlyBase:FBgn0002774}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1293
• Subcellular Localization: Nucleus . Chromosome . Mle is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females, and is associated with 30-40 autosomal sites in both sexes.
• Protein Description: Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X-chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction..
• Protein Sequence: MDIKSFLYQFCAKSQIEPKFDIRQTGPKNRQRFLCEVRVEPNTYIGVGNSTNKKDAEKNACRDFVNYLVRVGKLNTNDVPADAGASGGGPRTGLEGAGMAGGSGQQKRVFDGQSGPQDLGEAYRPLNHDGGDGGNRYSVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRIDSSQQDGEKRQESSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLRKLEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQLSMVSPLQVILFGSRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCVKSAGDFGLQRESGILPHQSRQFSDGGGPPKRGRFETGRFTNSSFGRRGNGRTFGGGYGNNGGGYGNNGGGYGNIGGGYGNNAGGYGNNGGYGNNGGGYRNNGGGYGNNGGGYGNKRGGFGDSFESNRGSGGGFRNGDQGGRWGNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
249	Phosphorylation	LNVIEPFSGTLKKKK HCCCCCCCCCCCCCC	41.40	19429919
251	Phosphorylation	VIEPFSGTLKKKKDE CCCCCCCCCCCCCCC	33.92	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MLE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MLE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLE_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMAL_DROME	Ama	physical	14605208
CCD22_DROME	CG9951	physical	14605208
KINH_DROME	Khc	genetic	8770597
SUV37_DROME	Su(var)3-7	genetic	18451980
MOF_DROME	mof	physical	11014199
MSL2_DROME	msl-2	physical	23870143
MSL2_DROME	msl-2	physical	9736618
MSL2_DROME	msl-2	physical	25694028
MSL1_DROME	msl-1	physical	23989663
MSL1_DROME	msl-1	physical	9736618
MSL1_DROME	msl-1	physical	25694028
TOP2_DROME	Top2	physical	23989663
MLE_DROME	mle	physical	9736618
MSL3_DROME	msl-3	physical	11014199
MSL3_DROME	msl-3	physical	9736618
MSL3_DROME	msl-3	physical	25694028
CHDM_DROME	Mi-2	physical	25776889
PEP_DROME	Pep	physical	25776889
RB87F_DROME	Hrb87F	physical	25776889

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.