dbPTM

SUV37_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SUV37_DROME
UniProt AC	P20193
Protein Name	Protein suppressor of variegation 3-7
Gene Name	Su(var)3-7
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1250
Subcellular Localization	Nucleus .
Protein Description	Dose-limiting factor in position-effect variegation, the inactivation in some cells of a gene translocated next to heterochromatin. It could play a role in chromosome condensation..
Protein Sequence	MDRDSSMQAKNLDAQCNPDLKMASANSETLASATHELKIMDVEGGALVDPDHIEEVETSMVIVVDDDDGDVAMVVEEDKHPMRDDPCIEDIMDDEHAPLVAELQSALNNPDDKQASEDPLLEDQEREPDAMSTKTEPSSDAESSHSYHDPMGLLERIEIHDPGDSQDDDDEDDESSNGGGVDGGMRRKMPRAQRWLLWMKRWPWILHEDSDGTLAFCLYCNISINVNNRSRHIQQHNVSLSHQERECNYLAFKKSEEETRGAISDNEIKHEFGTKSYVAAMKQKRISETEAFNNFNWLRWLRWHPWLERSMPTGTIGTCRICSVRMNVEFVYLRKRHETTKGHMEALRNLDSDKRSRKRKRSKSNSVTNSGGDEAEREKESEPEVGPEDAQDTPVVMMNGDVDSGDDPGKWCALIPDTNPQQCRCTLCNCTMAITSFLRHCKTRAHCHMLSTPAEKGSSDIRGIWAVFADMHPWLIADPEDPSIGYCSVCRKRFMYGNSEIKRKNHEKSEKHTLALASAKAGIEVGSADGRGGDNMDEEEAAASDQAQSSQTDDSEDNDDDNWSEIQKLGKGFAHKSSSEPRKATVRAGVRFYPWLCYSKDRKTQICKFCRVRFHNEAAKARHELSARHVKLVKQFKMRQAKLHQGTNTQTKHNAQDDEESQEQDEEYGEEEEDAEEDSQSNFDLGTVQARKTARADNKLFVKPIPATMKGKVMVWKGRFPWLSYKKNEQRGNYAWCKLCEVSLYLPSSKWASKHQRTSRHIRLRIDRKRNGGNPLKTSNKNSGEISTVVATASALASAEARQKAAMAELQAKYDWLDPDANDENHCHCRVCDSRLPIKVFYLRQHDASRKHVENKERQRANAAAAANAPSVSPTSTVDAERQESGMDKESENDMSVRSDGSTAEPLAKRSRRSMEVRRIIRALRDSMGKRQEERSQMDMARDMICSSFDIVTRLRTLERESVAHNESMAQAPPSVTVSPIKPPEPRHVMDLFFDSISPTMKSLPPDLAAEGKSKIMQLVCSLELRAMQRNATTPTPATVSASSKWPSSTTVTPVKTPPAPISAPLASVDADLHSSVVTTPHEYNNGQNNNNDKETVPKEPVTGASSAQVTINGSAKDLPENIRRILTSNQTQVTNRLETDSVRCVPLDKLTTQSRTNVNGRLSQGGTSEAPSTPQADLSNGNTLAMIRQIRVNNNNSSKITVTNTPQMQQPQQAQASITSSTPIMRGGPSSNGCQITTFRTMVNHNRRP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
116	Phosphorylation	NPDDKQASEDPLLED CCCCHHHCCCCCCCC	39.78	29892262
132	Phosphorylation	EREPDAMSTKTEPSS CCCCCCCCCCCCCCC	28.59	19429919
133	Phosphorylation	REPDAMSTKTEPSSD CCCCCCCCCCCCCCC	28.97	19429919
135	Phosphorylation	PDAMSTKTEPSSDAE CCCCCCCCCCCCCCC	53.90	19429919
138	Phosphorylation	MSTKTEPSSDAESSH CCCCCCCCCCCCCCC	34.32	19429919
139	Phosphorylation	STKTEPSSDAESSHS CCCCCCCCCCCCCCC	52.10	19429919
143	Phosphorylation	EPSSDAESSHSYHDP CCCCCCCCCCCCCCC	34.76	19429919
144	Phosphorylation	PSSDAESSHSYHDPM CCCCCCCCCCCCCCC	14.14	19429919
146	Phosphorylation	SDAESSHSYHDPMGL CCCCCCCCCCCCCCC	26.55	19429919
147	Phosphorylation	DAESSHSYHDPMGLL CCCCCCCCCCCCCCE	12.57	19429919
165	Phosphorylation	EIHDPGDSQDDDDED EEECCCCCCCCCCCC	41.23	19429919
175	Phosphorylation	DDDEDDESSNGGGVD CCCCCCCCCCCCCCC	35.78	19429919
176	Phosphorylation	DDEDDESSNGGGVDG CCCCCCCCCCCCCCH	37.13	19429919
264	Phosphorylation	EETRGAISDNEIKHE HHHCCCCCCCHHHHH	33.57	22817900
527	Phosphorylation	KAGIEVGSADGRGGD HCCCEECCCCCCCCC	28.50	19429919
839	Sumoylation	CDSRLPIKVFYLRQH CCCCCCEEEEEEECH	25.09	-
871	Phosphorylation	AAAANAPSVSPTSTV HHHHCCCCCCCCCCC	32.58	22817900
873	Phosphorylation	AANAPSVSPTSTVDA HHCCCCCCCCCCCCH	27.14	22817900
891	Phosphorylation	ESGMDKESENDMSVR HCCCCCCCCCCCCCC	47.65	19429919
896	Phosphorylation	KESENDMSVRSDGST CCCCCCCCCCCCCCC	19.76	19429919
899	Phosphorylation	ENDMSVRSDGSTAEP CCCCCCCCCCCCHHH	44.14	19429919
902	Phosphorylation	MSVRSDGSTAEPLAK CCCCCCCCCHHHHHH	29.45	19429919
903	Phosphorylation	SVRSDGSTAEPLAKR CCCCCCCCHHHHHHH	40.34	19429919
975	Phosphorylation	SMAQAPPSVTVSPIK HHCCCCCCEEECCCC	29.39	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SUV37_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SUV37_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SUV37_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NIPSN_DROME	Nipsnap	physical	14605208
HP1_DROME	Su(var)205	physical	11069770
MLE_DROME	mle	genetic	16234327
HP1_DROME	Su(var)205	physical	9311988

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SUV37_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-175; SER-176;SER-871; SER-873 AND SER-975, AND MASS SPECTROMETRY.	18327897 [Abstract]