dbPTM

HP1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HP1_DROME
UniProt AC	P05205
Protein Name	Heterochromatin protein 1
Gene Name	Su(var)205
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	206
Subcellular Localization	Nucleus, nucleoplasm . Chromosome . Colocalizes with Arp6 on centric heterochromatin.
Protein Description	Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression..
Protein Sequence	MGKKIDNPESSAKVSDAEEEEEEYAVEKIIDRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKSAASKKDRPSSSAKAKETQGRASSSTSTASKRKSEEPTAPSGNKSKRTTDAEQDTIPVSGSTGFDRGLEAEKILGASDNNGRLTFLIQFKGVDQAEMVPSSVANEKIPRMVIHFYEERLSWYSDNED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KKIDNPESSAKVSDA CCCCCHHHCCCCCCH	36.53	19429919
11	Phosphorylation	KIDNPESSAKVSDAE CCCCHHHCCCCCCHH	30.37	19429919
15	Phosphorylation	PESSAKVSDAEEEEE HHHCCCCCCHHHHHH	30.32	21082442
24	Phosphorylation	AEEEEEEYAVEKIID HHHHHHHHHHHHHHH	21.16	25749252
38	Acetylation	DRRVRKGKVEYYLKW HHHHHCCCCEEEEEE	34.62	21791702
89	Phosphorylation	ASKKDRPSSSAKAKE HHCCCCCCCHHHHHH	37.51	29892262
90	Phosphorylation	SKKDRPSSSAKAKET HCCCCCCCHHHHHHH	36.68	29892262
102	Phosphorylation	KETQGRASSSTSTAS HHHCCCCCCCCCCHH	24.38	25749252
103	Phosphorylation	ETQGRASSSTSTASK HHCCCCCCCCCCHHH	36.33	22817900
106	Phosphorylation	GRASSSTSTASKRKS CCCCCCCCCHHHHCC	24.75	27794539
109	Phosphorylation	SSSTSTASKRKSEEP CCCCCCHHHHCCCCC	32.84	27794539
113	Phosphorylation	STASKRKSEEPTAPS CCHHHHCCCCCCCCC	51.75	21082442
117	Phosphorylation	KRKSEEPTAPSGNKS HHCCCCCCCCCCCCC	55.25	19429919
120	Phosphorylation	SEEPTAPSGNKSKRT CCCCCCCCCCCCCCC	53.16	19429919
124	Phosphorylation	TAPSGNKSKRTTDAE CCCCCCCCCCCCCCC	31.22	19429919
127	Phosphorylation	SGNKSKRTTDAEQDT CCCCCCCCCCCCCCC	32.53	19429919
128	Phosphorylation	GNKSKRTTDAEQDTI CCCCCCCCCCCCCCC	36.93	19429919
134	Phosphorylation	TTDAEQDTIPVSGST CCCCCCCCCCCCCCC	27.20	18984573
199	Phosphorylation	HFYEERLSWYSDNED EHHHHHHHHCCCCCC	30.14	20450229
202	Phosphorylation	EERLSWYSDNED--- HHHHHHCCCCCC---	27.92	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HP1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HP1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HP1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MMD4_DROME	mod(mdg4)	genetic	8248257
SSRP1_DROME	Ssrp	physical	20889714
SPT16_DROME	dre4	physical	20889714
SMCA4_HUMAN	SMARCA4	physical	20011120
KDM4A_DROME	Kdm4A	physical	19061644
STAT_DROME	Stat92E	physical	18344984
SETB1_DROME	egg	genetic	19487560
NIPB_DROME	Nipped-B	physical	24990964
HP1_DROME	Su(var)205	physical	11566886
HP1_DROME	Su(var)205	physical	21472955
HP1_DROME	Su(var)205	physical	23793104
BOREA_DROME	borr	physical	24990964
PIWI_DROME	piwi	physical	17875665
PIWI_DROME	piwi	physical	21472955
PIWI_DROME	piwi	physical	23793104
ORC5_DROME	Orc5	physical	9363940
MCM10_DROME	Mcm10	physical	20498296
KDM4A_DROME	Kdm4A	physical	24990964
ORC6_DROME	Orc6	physical	9363940
SETB1_DROME	egg	physical	24990964
EZ_DROME	E(z)	physical	25954320
LSDA_DROME	Su(var)3-3	physical	24990964
PC_DROME	Pc	physical	25954320
SLE_DROME	sle	physical	24990964
SUV39_DROME	Su(var)3-9	physical	24990964
SUV39_DROME	Su(var)3-9	physical	11867540
SUV39_DROME	Su(var)3-9	physical	23559249
ORC2_DROME	Orc2	physical	9363940
SCC4_DROME	CG4203	physical	24990964
STAT_DROME	Stat92E	physical	25177369
CAV_DROME	cav	physical	11408576
CAV_DROME	cav	physical	12376620
CAV_DROME	cav	physical	12826664
CAV_DROME	cav	physical	19181850
CAV_DROME	cav	physical	26566042
ATRX_DROME	XNP	physical	24990964
H2AV_DROME	His2Av	physical	25591068
MES4_DROME	Mes-4	physical	24990964
SUUR_DROME	SuUR	physical	24990964
SUUR_DROME	SuUR	physical	18445687
SUZ12_DROME	Su(z)12	physical	25954320

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HP1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-15; SER-102;SER-103; SER-113 AND THR-128, AND MASS SPECTROMETRY.	18327897 [Abstract]
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; THR-127; THR-128 ANDTHR-134, AND MASS SPECTROMETRY.	17372656 [Abstract]