MES4_DROME - dbPTM
MES4_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MES4_DROME
UniProt AC Q8MT36
Protein Name Probable histone-lysine N-methyltransferase Mes-4
Gene Name Mes-4
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1427
Subcellular Localization Nucleus. Chromosome.
Protein Description Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity)..
Protein Sequence MKLSTDAHSEIEGDAAHGNVLCNSASDSLTATDEVAAGNDESVATEGDDVEIPRDTNNSTPVRLLDKPGQNPVQNGAQPAAEESELESQRQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDSDDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSANQLLSKTYMSPIEKLLIKNGASSPNSTGFEAGSEDLGIRPIVRKHVKRKMKRVPKAKVTLELDEKNQQEVDEKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVHIKQEDTIRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDLSSTALATSIKSPSSVSIDSAKGLSIVTDPGWPTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTSDVGSSLYDSTDNLHNKQGTQLLAVKRERSESPFSPAFSPVKSKNEKRAKRRKLSNGTEADTGSNSMAVTPSQTETTVDSSAYENPEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVVGRGSGVGTIKRLSNRLMTMMVRRSMTPVVTPSTTPAPSEPDRRLSEPPKTKKPVNRPIEEVIEDILQLDSKYLFRGLSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERKVTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVESPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVSDDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKADAHVNVLWCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPAIILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTGVEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLRFSQNLEDLSTCNCLPVDEHPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLKDDAVKAHAKLKQMRRAKASAVRIHVKPKKTPKVKHISADDEPMDAKDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
60PhosphorylationPRDTNNSTPVRLLDK
CCCCCCCCCEEECCC		28.1127626673
119PhosphorylationINLQSALSPKYIGYA
HHHHHHHCHHHCEEC		21.0425749252
130PhosphorylationIGYANANSPTPLSDS
CEECCCCCCCCCCCC		27.9530478224
140PhosphorylationPLSDSDDTIRTTRRR
CCCCCCHHHHHHHHH		19.8330478224
157PhosphorylationQAAALNNSSAGETLA
HHHHHCCCCCCCCCC		22.0822817900
158PhosphorylationAAALNNSSAGETLAH
HHHHCCCCCCCCCCC		42.2822817900
169PhosphorylationTLAHDNASPRTPGGG
CCCCCCCCCCCCCCC		22.5922817900
172PhosphorylationHDNASPRTPGGGGGG
CCCCCCCCCCCCCCC		29.6619429919
432PhosphorylationMPSHPQRSSLDNANV
CCCCCCCCCCCCCCC		29.9719429919
433PhosphorylationPSHPQRSSLDNANVP
CCCCCCCCCCCCCCC		41.7619429919
579PhosphorylationLAVKRERSESPFSPA
EEEEECCCCCCCCCC		37.3619429919
581PhosphorylationVKRERSESPFSPAFS
EEECCCCCCCCCCCC		32.2719429919
584PhosphorylationERSESPFSPAFSPVK
CCCCCCCCCCCCCCC		20.7825749252
588PhosphorylationSPFSPAFSPVKSKNE
CCCCCCCCCCCCCCH		30.7822817900
604PhosphorylationRAKRRKLSNGTEADT
HHHHHHCCCCCCCCC		35.9322817900
607PhosphorylationRRKLSNGTEADTGSN
HHHCCCCCCCCCCCC		32.0522817900
721PhosphorylationMTMMVRRSMTPVVTP
HHHHHHHCCCCCCCC		19.2222817900
723PhosphorylationMMVRRSMTPVVTPST
HHHHHCCCCCCCCCC		17.7422817900
830PhosphorylationALVIPPTSKSPSPDE
EEEECCCCCCCCCCC		36.5922817900
832PhosphorylationVIPPTSKSPSPDEDH
EECCCCCCCCCCCCC		30.3119429919
834PhosphorylationPPTSKSPSPDEDHVT
CCCCCCCCCCCCCCC		52.6619429919
1416PhosphorylationTPKVKHISADDEPMD
CCCCCEECCCCCCCC		25.9327626673
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MES4_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MES4_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MES4_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MES4_DROME !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MES4_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-158; SER-169;SER-433; SER-579; SER-581; SER-588; SER-604; THR-607; SER-721; THR-723AND SER-834, AND MASS SPECTROMETRY.

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