ATRX_DROME - dbPTM
ATRX_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATRX_DROME
UniProt AC Q9GQN5
Protein Name Transcriptional regulator ATRX homolog
Gene Name XNP
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1311
Subcellular Localization Nucleus.
Protein Description Could be a global transcriptional regulator. Modifies gene expression by affecting chromatin (Potential)..
Protein Sequence MGKKNPNARHTDAATPLTTDDSNSSSVSRRESATESKSASESESSPPRSNTKQSRTHKNVKASGKATVSSSSDSDQAVANSSANDEEKEPVCKIRIVPLEKLLASPKTKERPSRGSQQKNVTINDSSDEEPLKGSKLVLPARKSRNKNASIIELSDSEEVDEEEESLLVAIPLPKEAQQTKPEKNSSKASKESIEKRQKAQKEATTSSARAIRSVNGTRRGSLSSERSSRASSSRAESPPRPKRCVVRLKRVSLPKTKPAQKPKKMSSDSEEAATTSKKSRQRRSKSESEADSDYEAPAAEEEEEEERKSSGDEEEAANSSDSEVMPQRKRRRKKSESDKGSSDFEPEEKQKKKGRKRIKKTSSGESDGDGDDDKQKNKRKHIRKIIKTKDLDLTTKEAAKEEDDRRKRIEDRQKLYNRIFVKSESVEINELVLDFDEESKKALLQVDKGLLKKLKPHQVAGVKFMWDACFETLKESQEKPGSGCILAHCMGLGKTLQVVTLSHTLLVNTRRTGVDRVLIISPLSTVNNWAREFTSWMKFANRNDIEVYDISRYKDKPTRIFKLNEWFNEGGVCILGYDMYRILANEKAKGLRKKQREQLMQALVDPGPDLVVCDEGHLLKNEKTSISKAVTRMRTKRRIVLTGTPLQNNLREYYCMIQFVKPNLLGTYKEYMNRFVNPITNGQYTDSTERDLRLMKHRSHILHKLLEGCIQRRDYSVLAPYLPPKHEYVVYTTLSELQQKLYGYYMTTHREQSGGDVVGKGARLFQDFQDLRRIWTHPMNLRVNSDNVIAKRLLSNDDSDMEGFICDETDEDEAASNSSDSCETFKSDASMSGLAASSGKVKKRKTRNGNAGGGDSDSDLEMLGGLGGGSSVQKDDPSEWWKPFVEERELNNVHHSPKLLILLRLLQQCEAIGDKLLVFSQSLQSLDVIEHFLSLVDSNTKNYEFEGDVGDFKGCWTSGKDYFRLDGSCSVEQREAMCKQFNNITNLRARLFLISTRAGGLGINLVAANRVVIFDVSWNPSHDTQSIFRVYRFGQIKPCYIYRLIAMGTMEQKVYERQVAKQATAKRVIDEQQISRHYNQTDLMELYSYELKPSTEREMPILPKDRLFAEILTEHEKLIFKYHEHDSLLEQEEHENLTEEERKSAWAEYEAEKTRTVQASQYMSYDRNAFGNQVMGQFGNASGSVTSNKIFGFRSDILLQLLNMKISKDHQELNQNQVIQLVPTYLQQLYNEMNNGDPTMYKDLLNLHSNIVHPSGMYMNPLLYANQNPNAAGYNQGTGGVPPMAGGSVAHGPPAAPAPGFEPDKVYEID
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
105PhosphorylationPLEKLLASPKTKERP
EHHHHHCCCCCCCCC		27.2227626673
126PhosphorylationKNVTINDSSDEEPLK
CCEECCCCCCCCCCC		34.8921082442
127PhosphorylationNVTINDSSDEEPLKG
CEECCCCCCCCCCCC		52.4821082442
135PhosphorylationDEEPLKGSKLVLPAR
CCCCCCCCEEEECCC		22.6425749252
222PhosphorylationVNGTRRGSLSSERSS
CCCCCCCCCCHHHHH		24.2229892262
224PhosphorylationGTRRGSLSSERSSRA
CCCCCCCCHHHHHHH		31.6729892262
238PhosphorylationASSSRAESPPRPKRC
HHCCCCCCCCCCCCE		38.9422817900
253PhosphorylationVVRLKRVSLPKTKPA
EEEEEECCCCCCCCC		42.8827626673
267PhosphorylationAQKPKKMSSDSEEAA
CCCCCCCCCCHHHHH		39.6119429919
268PhosphorylationQKPKKMSSDSEEAAT
CCCCCCCCCHHHHHH		41.4819429919
270PhosphorylationPKKMSSDSEEAATTS
CCCCCCCHHHHHHHH		39.0119429919
275PhosphorylationSDSEEAATTSKKSRQ
CCHHHHHHHHHHHHH		38.3525749252
336PhosphorylationRKRRRKKSESDKGSS
HHHHHHHCCCCCCCC		45.4222817900
338PhosphorylationRRRKKSESDKGSSDF
HHHHHCCCCCCCCCC		52.2722817900
342PhosphorylationKSESDKGSSDFEPEE
HCCCCCCCCCCCHHH		32.2622817900
343PhosphorylationSESDKGSSDFEPEEK
CCCCCCCCCCCHHHH		55.7922817900
426PhosphorylationRIFVKSESVEINELV
HHHCCCCCEEEEEEE		31.9427794539
828PhosphorylationDSCETFKSDASMSGL
CCHHHHHCCCHHHHH		33.9319429919
831PhosphorylationETFKSDASMSGLAAS
HHHHCCCHHHHHHHC		20.6219429919
857PhosphorylationGNAGGGDSDSDLEML
CCCCCCCCHHHHHHC		42.1419429919
859PhosphorylationAGGGDSDSDLEMLGG
CCCCCCHHHHHHCCC		48.3119429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATRX_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATRX_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATRX_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HP1_DROMESu(var)205physical
20154359
JING_DROMEjinggenetic
16648585
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATRX_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126; SER-127; SER-267;SER-268; SER-270; SER-336; SER-338; SER-342; SER-343; SER-857 ANDSER-859, AND MASS SPECTROMETRY.

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