SLE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLE_DROME
• UniProt AC: Q8INM3
• Protein Name: Protein slender lobes
• Gene Name: sle
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1420
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Required for the correct organization of the nucleolus during development..
• Protein Sequence: MVVTRARTRRLSLLETDSRPSTPQLDTVAELGTASPRATRRTRLNSSTLDVRTPTRTRRASLARGETPEPTTPSSVKRTARTPAKNTRSVRQQLTLTEEPEENEVKQEKPSPSPSPVPKEGKGKAQRKPSVSPSPGRTLTPNQQSDEKRVTRSMSQTPPMPTRSSSNTPRDLNDSPKVEQKAKPNIKTTPKVAVRLEKLSMDKFSGKKMEKAKPLIVPDELKDNGVVEEQNKSITEAHSQAPETHESAQPDKDAGKQSFLKSFTTLSKIQGSSKALHPDESADTITKITPTSTSKKIEENMDDVFETLRVESPKVERKIETLQKVHTVGTPEIKEKDEPVGVDNEIKTKTETPQKIEPPIIESKVETQQLIDHPQIEKKRDTPQNVSTVDLMDTSPEKDESMEDQEFLDAEDSIVQLEPQTDEPVEKPKELEFVDLDDDEPVFPSEAPKYVEDSKEVHPDDSMDDDKQNKIDVTEVIHLPSIRARAVRSPAVEQKKSVDFNNDTDDLEVEKKRFPKTPGREKVPVCRILTPKPETPLKLALQKGRNSSTPILKDQERGLSNSTEELHPAPPQIDAIKPFDELESKNAKDEMVEQSPMSKQKAENKILARLESFEEDVEDHGNEEENEEEHEEDKSISEFVDLEAEDAGKDYMSGDSMDSSLRREMEENEIPIDGESVGSKDTEESTPEESDGDDSFIVSDNEDEEDLGQLCYSSGEDEIEDAEESEQAERSSVKRRRIIIASPSDEEHDGKVQSNDDSSENKTEKPKNQSNCSSNASKLSEAAQLLNVSEEKSSISETELERSRQVALNELNKSERFNKTETQLDISVMEVDSSDHDEEEKTEKVGAKNNRSLYEIVDSDDGEEQDQDQSDADKPAESENHSEIKKSTSFMDQMSGAKGNKSVYEIMDSYETEDPKEAGKNEESDKDKPAENGKSDKDKQAETEMSDEDKPSEIKSPSTIKKSIISTADEEALLAELASSDLSHLEKMFNPLQKSRRQSLHVPSPELAAKNPKLRRRSERVEVGNDFCPSQSFVDMVAEKKRQKNKRKRLSKSLSGAPEDLEEMEIKHERKRLKSSHGASTDSMEEDNENETMTVAEEHHSDGEVSNGEVPIEEKPTTSSEKPSASELPEEEETVAVEELLMEKPKTCDSPRSEERPTEIVTSKPKGMAPVKVEKTAEYYLAYCHNLLEAANEAKLKEKKEHLASGAKQKKPKRIAAQAPSKLLGTIGSESETNTAKSSKQPPALKKDVKRLQAARQAVSHAVNLLAPPKATEAEPRTLSRKLSPQPPVVDKKSAKQKKGKKKQKPQEASPLKSSDEENHGHRIRTNAGYVTVVDEPPTKVPKIELIKTSSGMVRVEPCTPKQKYFRELPPTPKMHGFREEPGPSGMSRKRAKHAAPKVEHNSAKQAALRFKEQIFARRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RARTRRLSLLETDSR CCHHHCHHHHCCCCC	29.15	19429919
16	Phosphorylation	RRLSLLETDSRPSTP HCHHHHCCCCCCCCC	38.96	19429919
18	Phosphorylation	LSLLETDSRPSTPQL HHHHCCCCCCCCCCC	54.21	19429919
21	Phosphorylation	LETDSRPSTPQLDTV HCCCCCCCCCCCCHH	52.16	19429919
22	Phosphorylation	ETDSRPSTPQLDTVA CCCCCCCCCCCCHHH	20.10	19429919
27	Phosphorylation	PSTPQLDTVAELGTA CCCCCCCHHHHHCCC	30.15	23607784
33	Phosphorylation	DTVAELGTASPRATR CHHHHHCCCCHHHCC	36.26	19429919
35	Phosphorylation	VAELGTASPRATRRT HHHHCCCCHHHCCHH	18.11	19429919
42	Phosphorylation	SPRATRRTRLNSSTL CHHHCCHHCCCCCCC	35.90	23607784
46	Phosphorylation	TRRTRLNSSTLDVRT CCHHCCCCCCCCCCC	29.32	21082442
47	Phosphorylation	RRTRLNSSTLDVRTP CHHCCCCCCCCCCCC	31.73	19429919
48	Phosphorylation	RTRLNSSTLDVRTPT HHCCCCCCCCCCCCC	27.14	19429919
53	Phosphorylation	SSTLDVRTPTRTRRA CCCCCCCCCCHHHCH	28.94	28490779
55	Phosphorylation	TLDVRTPTRTRRASL CCCCCCCCHHHCHHH	44.02	23607784
57	Phosphorylation	DVRTPTRTRRASLAR CCCCCCHHHCHHHHC	27.30	18327897
61	Phosphorylation	PTRTRRASLARGETP CCHHHCHHHHCCCCC	22.28	25749252
67	Phosphorylation	ASLARGETPEPTTPS HHHHCCCCCCCCCCH	35.46	21082442
71	Phosphorylation	RGETPEPTTPSSVKR CCCCCCCCCCHHHHH	50.07	19429919
72	Phosphorylation	GETPEPTTPSSVKRT CCCCCCCCCHHHHHC	31.71	21082442
74	Phosphorylation	TPEPTTPSSVKRTAR CCCCCCCHHHHHCCC	45.75	19429919
75	Phosphorylation	PEPTTPSSVKRTART CCCCCCHHHHHCCCC	32.63	28490779
82	Phosphorylation	SVKRTARTPAKNTRS HHHHCCCCCCCCCHH	25.74	27626673
95	Phosphorylation	RSVRQQLTLTEEPEE HHHHHHHCCCCCCCC	27.56	19429919
97	Phosphorylation	VRQQLTLTEEPEENE HHHHHCCCCCCCCCC	32.82	23607784
111	Phosphorylation	EVKQEKPSPSPSPVP CCCCCCCCCCCCCCC	49.42	21082442
113	Phosphorylation	KQEKPSPSPSPVPKE CCCCCCCCCCCCCCC	42.20	19429919
115	Phosphorylation	EKPSPSPSPVPKEGK CCCCCCCCCCCCCCC	42.75	21082442
130	Phosphorylation	GKAQRKPSVSPSPGR CCCCCCCCCCCCCCC	37.96	21082442
132	Phosphorylation	AQRKPSVSPSPGRTL CCCCCCCCCCCCCCC	24.81	21082442
134	Phosphorylation	RKPSVSPSPGRTLTP CCCCCCCCCCCCCCC	32.26	19429919
138	Phosphorylation	VSPSPGRTLTPNQQS CCCCCCCCCCCCCCC	40.68	22817900
140	Phosphorylation	PSPGRTLTPNQQSDE CCCCCCCCCCCCCCC	21.41	28490779
145	Phosphorylation	TLTPNQQSDEKRVTR CCCCCCCCCCCCCCC	37.66	28490779
153	Phosphorylation	DEKRVTRSMSQTPPM CCCCCCCCCCCCCCC	17.27	19429919
155	Phosphorylation	KRVTRSMSQTPPMPT CCCCCCCCCCCCCCC	31.95	19429919
157	Phosphorylation	VTRSMSQTPPMPTRS CCCCCCCCCCCCCCC	23.27	19429919
162	Phosphorylation	SQTPPMPTRSSSNTP CCCCCCCCCCCCCCC	36.61	27626673
165	Phosphorylation	PPMPTRSSSNTPRDL CCCCCCCCCCCCCCC	25.07	18327897
175	Phosphorylation	TPRDLNDSPKVEQKA CCCCCCCCHHHHHHC	26.08	21082442
200	Phosphorylation	AVRLEKLSMDKFSGK HHHHHHHHCCCCCCC	35.68	22817900
205	Phosphorylation	KLSMDKFSGKKMEKA HHHCCCCCCCCCCCC	56.28	22817900
233	Phosphorylation	VVEEQNKSITEAHSQ CCCCHHHCHHHHHHC	42.14	19429919
235	Phosphorylation	EEQNKSITEAHSQAP CCHHHCHHHHHHCCC	33.92	19429919
239	Phosphorylation	KSITEAHSQAPETHE HCHHHHHHCCCCCCH	34.78	22668510
244	Phosphorylation	AHSQAPETHESAQPD HHHCCCCCCHHCCCC	29.86	19429919
247	Phosphorylation	QAPETHESAQPDKDA CCCCCCHHCCCCCCC	25.30	19429919
274	Acetylation	SKIQGSSKALHPDES HHHCCCCCCCCCCCC	57.58	21791702
289	Phosphorylation	ADTITKITPTSTSKK CCCEEECCCCCCCHH	23.28	28490779
307	Phosphorylation	NMDDVFETLRVESPK CHHHHHHHHHCCCHH	14.38	18327897
312	Phosphorylation	FETLRVESPKVERKI HHHHHCCCHHHHHHH	27.45	19429919
327	Phosphorylation	ETLQKVHTVGTPEIK HHHHHHHCCCCCCCC	24.50	19429919
330	Phosphorylation	QKVHTVGTPEIKEKD HHHHCCCCCCCCCCC	17.26	19429919
348	Phosphorylation	GVDNEIKTKTETPQK CCCCCCCCCCCCCCC	49.19	18327897
350	Phosphorylation	DNEIKTKTETPQKIE CCCCCCCCCCCCCCC	50.77	28490779
352	Phosphorylation	EIKTKTETPQKIEPP CCCCCCCCCCCCCCC	35.93	28490779
363	Phosphorylation	IEPPIIESKVETQQL CCCCCCCCCCCHHHH	31.43	22817900
382	Phosphorylation	QIEKKRDTPQNVSTV HHHCCCCCCCCCCCC	30.70	22668510
388	Phosphorylation	DTPQNVSTVDLMDTS CCCCCCCCCCCCCCC	17.47	22668510
394	Phosphorylation	STVDLMDTSPEKDES CCCCCCCCCCCCCCC	32.01	19429919
395	Phosphorylation	TVDLMDTSPEKDESM CCCCCCCCCCCCCCC	27.14	19429919
401	Phosphorylation	TSPEKDESMEDQEFL CCCCCCCCCCCHHHH	37.29	19429919
413	Phosphorylation	EFLDAEDSIVQLEPQ HHHCHHHHEEEECCC	19.03	18327897
454	Phosphorylation	APKYVEDSKEVHPDD CCCCCCCCCCCCCCC	19.74	22817900
462	Phosphorylation	KEVHPDDSMDDDKQN CCCCCCCCCCHHHHC	31.34	21082442
474	Phosphorylation	KQNKIDVTEVIHLPS HHCCCCEEEEEECHH	22.31	22668510
489	Phosphorylation	IRARAVRSPAVEQKK HHHHHCCCCHHHCHH	15.60	19429919
497	Phosphorylation	PAVEQKKSVDFNNDT CHHHCHHCCCCCCCC	33.67	19429919
530	Phosphorylation	VPVCRILTPKPETPL CCEEEEECCCCCCCH	27.22	19429919
535	Phosphorylation	ILTPKPETPLKLALQ EECCCCCCCHHHHHH	42.31	19429919
547	Phosphorylation	ALQKGRNSSTPILKD HHHCCCCCCCCCHHC	33.94	19429919
548	Phosphorylation	LQKGRNSSTPILKDQ HHCCCCCCCCCHHCC	41.57	19429919
549	Phosphorylation	QKGRNSSTPILKDQE HCCCCCCCCCHHCCC	17.73	19429919
560	Phosphorylation	KDQERGLSNSTEELH HCCCCCCCCCCCCCC	31.40	21082442
562	Phosphorylation	QERGLSNSTEELHPA CCCCCCCCCCCCCCC	33.54	21082442
563	Phosphorylation	ERGLSNSTEELHPAP CCCCCCCCCCCCCCC	37.42	19429919
595	Phosphorylation	KDEMVEQSPMSKQKA HHHHHHHCCCHHHHH	14.74	21082442
598	Phosphorylation	MVEQSPMSKQKAENK HHHHCCCHHHHHHHH	35.01	21082442
612	Phosphorylation	KILARLESFEEDVED HHHHHHHHHHHHHHH	42.42	19429919
635	Phosphorylation	EEHEEDKSISEFVDL HHHHHHCCHHHHHHH	43.60	19429919
637	Phosphorylation	HEEDKSISEFVDLEA HHHHCCHHHHHHHHH	31.88	22817900
651	Phosphorylation	AEDAGKDYMSGDSMD HHHCCCCCCCCCCCC	9.18	20450229
653	Phosphorylation	DAGKDYMSGDSMDSS HCCCCCCCCCCCCHH	32.97	19429919
656	Phosphorylation	KDYMSGDSMDSSLRR CCCCCCCCCCHHHHH	28.19	19429919
659	Phosphorylation	MSGDSMDSSLRREME CCCCCCCHHHHHHHH	23.72	19429919
660	Phosphorylation	SGDSMDSSLRREMEE CCCCCCHHHHHHHHH	22.95	22817900
676	Phosphorylation	EIPIDGESVGSKDTE CCCCCCCCCCCCCCC	36.99	19429919
679	Phosphorylation	IDGESVGSKDTEEST CCCCCCCCCCCCCCC	25.79	19429919
732	Phosphorylation	SEQAERSSVKRRRII HHHHHHHCCCCCEEE	37.57	18327897
742	Phosphorylation	RRRIIIASPSDEEHD CCEEEEECCCHHHCC	17.96	21082442
744	Phosphorylation	RIIIASPSDEEHDGK EEEEECCCHHHCCCC	55.98	21082442
754	Phosphorylation	EHDGKVQSNDDSSEN HCCCCCCCCCCCCCC	45.26	19429919
758	Phosphorylation	KVQSNDDSSENKTEK CCCCCCCCCCCCCCC	42.27	22817900
759	Phosphorylation	VQSNDDSSENKTEKP CCCCCCCCCCCCCCC	52.78	19060867
763	Phosphorylation	DDSSENKTEKPKNQS CCCCCCCCCCCCCCC	61.90	18327897
780	Phosphorylation	SSNASKLSEAAQLLN CCHHHHHHHHHHHCC	29.00	29892262
789	Phosphorylation	AAQLLNVSEEKSSIS HHHHCCCCHHHCCCC	38.68	22817900
793	Phosphorylation	LNVSEEKSSISETEL CCCCHHHCCCCHHHH	35.86	19429919
794	Phosphorylation	NVSEEKSSISETELE CCCHHHCCCCHHHHH	41.00	19429919
796	Phosphorylation	SEEKSSISETELERS CHHHCCCCHHHHHHH	40.17	23607784
814	Phosphorylation	ALNELNKSERFNKTE HHHHCCHHHHCCCCC	32.69	25749252
820	Phosphorylation	KSERFNKTETQLDIS HHHHCCCCCCEEEEE	45.42	22817900
827	Phosphorylation	TETQLDISVMEVDSS CCCEEEEEEEECCCC	18.32	23607784
833	Phosphorylation	ISVMEVDSSDHDEEE EEEEECCCCCCCHHH	42.72	23607784
834	Phosphorylation	SVMEVDSSDHDEEEK EEEECCCCCCCHHHH	34.20	25749252
842	Phosphorylation	DHDEEEKTEKVGAKN CCCHHHHHHCCCCCC	44.30	23607784
852	Phosphorylation	VGAKNNRSLYEIVDS CCCCCCCCCEEEECC	37.11	22817900
859	Phosphorylation	SLYEIVDSDDGEEQD CCEEEECCCCCCCCC	27.06	19429919
870	Phosphorylation	EEQDQDQSDADKPAE CCCCCCCCCCCCCCC	42.95	23607784
878	Phosphorylation	DADKPAESENHSEIK CCCCCCCCCCHHHHH	45.89	22668510
882	Phosphorylation	PAESENHSEIKKSTS CCCCCCHHHHHHHHC	53.23	22668510
887	Phosphorylation	NHSEIKKSTSFMDQM CHHHHHHHHCHHHHH	25.04	19429919
888	Phosphorylation	HSEIKKSTSFMDQMS HHHHHHHHCHHHHHC	34.56	19429919
889	Phosphorylation	SEIKKSTSFMDQMSG HHHHHHHCHHHHHCC	26.18	19429919
898	Acetylation	MDQMSGAKGNKSVYE HHHHCCCCCCHHHHH	67.55	21791702
902	Phosphorylation	SGAKGNKSVYEIMDS CCCCCCHHHHHHHHH	33.65	22817900
904	Phosphorylation	AKGNKSVYEIMDSYE CCCCHHHHHHHHHCC	13.56	22817900
924	Phosphorylation	EAGKNEESDKDKPAE HCCCCCCCCCCCCCC	43.72	19429919
943	Phosphorylation	DKDKQAETEMSDEDK HHHHHHHHHCCCCCC	39.75	19429919
946	Phosphorylation	KQAETEMSDEDKPSE HHHHHHCCCCCCCCC	31.45	21082442
952	Phosphorylation	MSDEDKPSEIKSPST CCCCCCCCCCCCHHH	58.66	18327897
956	Phosphorylation	DKPSEIKSPSTIKKS CCCCCCCCHHHHHHH	29.73	22817900
958	Phosphorylation	PSEIKSPSTIKKSII CCCCCCHHHHHHHHH	50.27	22817900
963	Phosphorylation	SPSTIKKSIISTADE CHHHHHHHHHHCCCH	21.83	19429919
966	Phosphorylation	TIKKSIISTADEEAL HHHHHHHHCCCHHHH	18.84	19429919
967	Phosphorylation	IKKSIISTADEEALL HHHHHHHCCCHHHHH	27.93	19429919
999	Phosphorylation	LQKSRRQSLHVPSPE HHHHHHHHCCCCCHH	20.73	21082442
1004	Phosphorylation	RQSLHVPSPELAAKN HHHCCCCCHHHHHHC	29.89	21082442
1030	Phosphorylation	VGNDFCPSQSFVDMV CCCCCCCCHHHHHHH	39.37	18511481
1032	Phosphorylation	NDFCPSQSFVDMVAE CCCCCCHHHHHHHHH	31.41	22817900
1051	Phosphorylation	KNKRKRLSKSLSGAP HHHHHHHHHHHCCCC	25.00	22817900
1053	Phosphorylation	KRKRLSKSLSGAPED HHHHHHHHHCCCCHH	25.13	21082442
1055	Phosphorylation	KRLSKSLSGAPEDLE HHHHHHHCCCCHHHH	39.74	19429919
1147	Phosphorylation	LLMEKPKTCDSPRSE HHHHCCCCCCCCCCC	30.03	21082442
1150	Phosphorylation	EKPKTCDSPRSEERP HCCCCCCCCCCCCCC	25.10	19429919
1153	Phosphorylation	KTCDSPRSEERPTEI CCCCCCCCCCCCCEE	47.39	19429919
1158	Phosphorylation	PRSEERPTEIVTSKP CCCCCCCCEEECCCC	44.56	19060867
1226	Phosphorylation	APSKLLGTIGSESET CCHHHHHCCCCCCCC	23.33	30478224
1229	Phosphorylation	KLLGTIGSESETNTA HHHHCCCCCCCCCCC	33.81	28490779
1231	Phosphorylation	LGTIGSESETNTAKS HHCCCCCCCCCCCHH	51.96	22668510
1233	Phosphorylation	TIGSESETNTAKSSK CCCCCCCCCCCHHCC	47.34	22668510
1235	Phosphorylation	GSESETNTAKSSKQP CCCCCCCCCHHCCCC	42.77	30478224
1284	Phosphorylation	RTLSRKLSPQPPVVD CCHHHCCCCCCCCCC	25.23	19429919
1310	Phosphorylation	KQKPQEASPLKSSDE CCCCCCCCCCCCCCC	29.97	19429919
1314	Phosphorylation	QEASPLKSSDEENHG CCCCCCCCCCCCCCC	51.18	19429919
1315	Phosphorylation	EASPLKSSDEENHGH CCCCCCCCCCCCCCC	47.67	19429919
1360	Phosphorylation	MVRVEPCTPKQKYFR CEEEEECCCCHHHHH	44.21	27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLE_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP6A_DROME	Hsp67Ba	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-18; SER-21;THR-27; THR-33; SER-35; THR-42; SER-46; THR-53; THR-55; SER-61;THR-67; THR-72; SER-75; SER-111; SER-113; SER-115; SER-130; SER-132;SER-134; THR-140; SER-145; SER-153; SER-155; THR-157; SER-175;SER-233; THR-307; SER-312; THR-348; THR-352; THR-394; SER-395;SER-401; SER-413; SER-454; SER-462; THR-530; THR-535; SER-547;SER-548; SER-560; SER-562; THR-563; SER-595; SER-612; SER-635;SER-637; SER-653; SER-656; SER-659; SER-660; SER-742; SER-744;SER-754; SER-758; SER-759; THR-763; SER-789; SER-794; SER-796;THR-820; SER-827; SER-833; SER-834; THR-842; SER-852; SER-859;SER-870; SER-889; SER-902; TYR-904; SER-946; SER-952; SER-956;SER-999; SER-1004; SER-1051; SER-1053; SER-1055; SER-1150; SER-1153;THR-1158; SER-1310; SER-1314 AND SER-1315, AND MASS SPECTROMETRY.
PubMed: 18327897

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-560; SER-562;THR-563; SER-612; SER-796; SER-889; SER-999; SER-1032; SER-1055 ANDSER-1229, AND MASS SPECTROMETRY.
PubMed: 17372656