NIPB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NIPB_DROME
• UniProt AC: Q7PLI2
• Protein Name: Nipped-B protein
• Gene Name: Nipped-B
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2077
• Subcellular Localization: Nucleus .
• Protein Description: Plays a structural role in chromatin. Involved in sister chromatid cohesion, probably via an interaction with the cohesin complex. Participates in the transcriptional activation mediated by remote enhancers on genes such as cut and Ubx, possibly by alleviating the cohesin-mediated blocking of enhancer-promoter communication..
• Protein Sequence: MGERDNPTVPVTTLAGLTSTSDLLSELPVADSLQSAASLNKSLLFHALVANESSNLLSMRNENLVRQLVTAIERTNSDNIELIHCPVQDTATNCSTYPELLQGIYHFRPAVFNTSIKIHSPDQHTANARLEAKKMQIDSYSIPECYASPTNLSISNEHQLQDAQACFNQLTSMTSKEILEEFSQINFKENATEKDKIDVIENSDLNVTKILSQNTLKKKSNTPERSTVQSIQEQFFIQQQEANYNLKHDLNQVSTNVGQIQNISDTFPQEPSNFNLNSVNIPNMLYVQSPPFTESEPTQAHHSSIEYLKKKKSQILDVSILNRQQVLENTSLHIINKSSTYQTNQNVSTTTSTSTSSSGKSQVRVCINRLSIEDSRLMQQSIKKFVQKSPELARSMGLLQETCQQQHENLNIIPTSAEECVLESRASSTNNTVKIPIDTFSTIKADEKRSAKRKLAISIGDIPPEQIFSKPKMRRVERITPLSNTKCVKEEVTRSQTYQQFIRNMDHIIEILDDSESPNFDSEDVDETIECISSKLLNSMSTDVAKLKAKQALDSIPKNKLTLLINYAMRNVYLARNYFAGTEDEDEFVDDEVIEKLLNAMDACLLICNIYSTVSDLQFLQEDNVSHIIKFTQFQLRETIFPLHDPVYTAKSIKRTTHRKKIKSHQAQNRSMQLFYLKTVELLKVFVTLFDKCVFVDTIVLPLSTLAIEPFFVDNIETLQFVCLELVTTIFRKERYDKIRNSILGDILTSIDRLPSSKKNLRPYKLTNNGGNIQMVTALVLQLIQCATILPDSLCDNGKFSNKPQEGNTFDEEGKKLLQPSQDLLVLQKYDVAVSIGGNFLTTFLNKCKSRSNETDFRPLFENFIHDLLATVNKPEWPASELLLSLLGTMLVRYVSDKGIEQSIRLVSLDYLGIVAARLRKDTVESRCRVNIIDSMIQSIKLEQEKEGDVTSNNDQFDLEPEEQRTDFLQKILLDFLAVNAQEENLIWDYARHFYLAQWYRDVIYQRRRINDGKKGLAFRKSKIRNNRRTNGDYLDTSDSGSCDESDTDTNKKRIHCVDSNDFELNINIYKALEARKQYFINKIKPFSVFGEQNHSSNQHIKTYIDYNNAQLIAQYLATKRPFSQSFDGCLKKIILVVNEPSIAVRTRAMKCLANIVEVDPLVLKRKDMQMGVNQKFLDTAISVREAAVDLVGKFVLSNQDLIDQYYDMLSTRILDTGVSVRKRVIKILRDICLEYPDFSKIPEICVKMIRRVHDEEGIQKLVTEVFMKMWFTPCTKNDKIGIQRKINHIIDVVNTAHDTGTTWLEGLLMSIFKPRDNMLRSEGCVQEFIKKNSEPPMDIVIACQQLADGLVDRLIELEDTDNSRMLGCITTLHLLAKVRPQLLVKHAITIEPYLNIKCHSATAAKFICAVADILEKVVPLVNNASESFLASLEEHLMLLVVSRNQAEVTSCVSCLGALVNKITHNFKLIRDCFQKFYRVLDVSRSQVIQGNNSVDNIYTPSFRRSLFTIGILMRYFDFKSPIALGETNDGLPVSICEDVFHCLMFFCRCTNQEIRKQALISLGSFCVLNDGYLTRSELKNLYCEILSSIANDAGFKIICMRNIWIYLTESEMFMHNKEKEWEKQSKHEDLKEMNDVSSGMASRIIQLYLEEILECFLNRDDTVRLWAVKVIQIVLRQGLVHPVRMVPYLICLSTDHRIESAHRADALLKDIDKTYSGFVNMKVQFGLQLCFKLQKILQINNRGKLEIIRGYASRGPDNTTTALNDFLYTLLRTTKPQRRALVQTVTKQFDDQKTSLQQMLYIADNLAYFPYVVQDEPLYLIHQIDLLISMAGTHLLATFKEHIKPSDKEGDVLEDDDDVEDPEVLFNRLPEDLTEIIKCITSAQACMLLLILKDHLKEMYAITDSKISRYSPSEQKLYEKAVTRKSVNDFNPKTTIDVIKKQMSQEKLSTDINFTLTKEEKLDLVVKYLDFKQLMLKLDPDDGDSDADESRDKTMLNISASSDGVAFSSSAKNSHSACDGYSLTVTDVVDVPMSHIAKASMLTSKPSGRKTNPVRTKKKRRKIDSTDDETSDAEYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	NTSIKIHSPDQHTAN CCEEEECCCCCHHHH	33.38	19429919
222	Phosphorylation	TLKKKSNTPERSTVQ CHHCCCCCCCHHHHH	33.35	27626673
389	Phosphorylation	IKKFVQKSPELARSM HHHHHHHCHHHHHHH	13.40	22817900
1986	Phosphorylation	LDPDDGDSDADESRD CCCCCCCCCCHHHCC	39.98	19429919
1991	Phosphorylation	GDSDADESRDKTMLN CCCCCHHHCCCEEEE	46.45	22817900
2066	Phosphorylation	KKRRKIDSTDDETSD CCCCCCCCCCCCCCC	36.89	19429919
2067	Phosphorylation	KRRKIDSTDDETSDA CCCCCCCCCCCCCCC	43.66	19429919
2071	Phosphorylation	IDSTDDETSDAEYA- CCCCCCCCCCCCCC-	38.61	19429919
2072	Phosphorylation	DSTDDETSDAEYA-- CCCCCCCCCCCCC--	32.54	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NIPB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NIPB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NIPB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCC4_DROME	CG4203	physical	14605208
SCC4_DROME	CG4203	physical	16802858
MYC_DROME	dm	genetic	26544867
CHDM_DROME	Mi-2	genetic	22912596

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1986; SER-1991; SER-2066AND THR-2067, AND MASS SPECTROMETRY.
PubMed: 18327897