SUUR_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUUR_DROME
• UniProt AC: Q9VTE2
• Protein Name: Protein suppressor of underreplication
• Gene Name: SuUR
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 962
• Subcellular Localization: Nucleus. Chromosome. Binds to polytene chromosomes from salivary glands. Localized at late-replicating intercalary heterochromatin and pericentric heterochromatin. Colocalizes with many Polycomb Group proteins binding sites on polytene chromosomes.
• Protein Description: Required for underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes. Controls chromatin organization in polytene chromosomes..
• Protein Sequence: MYHFVSEQTPEVRLTDEALVTSHVTQYLKSFQLDAVRFVYDRLAKREFCILNDESGLGKVATVAALLSALPPAKKTLVVLQNDEQLLTGWRFHLDTLTDLQVYIIQGVQDTTDSPHSVYLAKWSQLRSIGDLSRLKFDYIMVDNRGHSLNNSFCTSMLLKQFEGRVNVLISSVDVTSDVRLLYNVLRLGGRLEHQYKSFASFDRKFHLPDPKEVFSKRIDLEEYYKQRGFLSEYIKDFRLRRFRHQFDKSLPLVAPEQYKHNLNLWLASKNSQSTISGSDVCSTIASIDNNPAQQNKTGLFEETDRLSEHSVDDVAMSPLIFEYSESDDEPLTVEPDADQNPVLVVSSDDCEIVTPPSTPQNRTPSLNESPRTKSKKKFSKKTSPRKKADLTDSEEDDEATDNMPPRKRTRAATVHLTPKTRRLNVRILRVSLDTLSTPPPSRTTTAIVTPKTEPTARRKNLKKRTVSPVDVGRPATRGMQRLTRSAETKINSKYLKHRSLDDVKRSFPRRVKLEGNQTPRSSKQIVKQEPKSKVGQEKKQKTVDVPAQGTAKRKPGRPRKCQTKTEDLGKTKTKPNSKHLPPTPQVLSGSSLSSEYMQCAQRIPDNLDAIESPAFRVPFTPQQTPMLLTLPSTHNLLNDSEVVSIPLYKDPVETVVINSSHDECSPQDPSQSRRTKALKRKRKPVTSVNSSFGGGLGLPPAKRSANKSPDLFSISSEHSQIPLAQPRPSSPFEGFKIFGSEVKQFQQQLAKVNISVPKKKRDRSCLDILEQMFEPRQQQSAKTSPKVLPTLPLTQKDDAESTITQRRRTLLEDDFFEITNNGQFGSRMRLNSSGEVSPVQPDQQSVRPSQANKITNYLIGSGITQERTQPSNGNRNSILASLRKSPKSPKQGAKSTQATKLTRWFGSVFGGGASQTSSVESVSAPSTPVNSSTSAAACQTRSARSGGASGPTKRKRLELFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
370	Phosphorylation	RTPSLNESPRTKSKK CCCCCCCCCCCCCHH	20.71	27626673
418	Phosphorylation	RAATVHLTPKTRRLN CEEEEECCCCCCCCC	14.09	22817900
432	Phosphorylation	NVRILRVSLDTLSTP CEEEEEEEHHHCCCC	17.69	22817900
438	Phosphorylation	VSLDTLSTPPPSRTT EEHHHCCCCCCCCCE	42.82	22817900
466	Phosphorylation	RKNLKKRTVSPVDVG HHCCCCCCCCCCCCC	33.93	19429919
468	Phosphorylation	NLKKRTVSPVDVGRP CCCCCCCCCCCCCCH	20.70	19429919
477	Phosphorylation	VDVGRPATRGMQRLT CCCCCHHHHHHHHHH	30.36	19429919
709	Phosphorylation	AKRSANKSPDLFSIS HHCCCCCCCCCEECC	24.37	19429919
731	Phosphorylation	LAQPRPSSPFEGFKI CCCCCCCCCCCCCEE	35.97	27794539
810	Phosphorylation	TITQRRRTLLEDDFF HHHHHHHHHHHCCEE	33.61	22817900
827	Phosphorylation	TNNGQFGSRMRLNSS CCCCCCCCCEEECCC	24.96	22817900
833	Phosphorylation	GSRMRLNSSGEVSPV CCCEEECCCCCCCCC	44.29	22817900
834	Phosphorylation	SRMRLNSSGEVSPVQ CCEEECCCCCCCCCC	37.59	22817900
838	Phosphorylation	LNSSGEVSPVQPDQQ ECCCCCCCCCCCCCC	18.30	22817900
856	Phosphorylation	PSQANKITNYLIGSG HHHHHHHHHHHHCCC	21.30	22668510
862	Phosphorylation	ITNYLIGSGITQERT HHHHHHCCCCCCCCC	21.74	22668510
878	Phosphorylation	PSNGNRNSILASLRK CCCCCCCHHHHHHHC	18.75	22668510
882	Phosphorylation	NRNSILASLRKSPKS CCCHHHHHHHCCCCC	25.84	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUUR_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUUR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUUR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HP1_DROME	Su(var)205	physical	18445687
PCNA_DROME	PCNA	physical	23149855

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432; THR-438; THR-466;SER-468; THR-810; SER-827; SER-833; SER-834 AND SER-838, AND MASSSPECTROMETRY.
PubMed: 18327897