MCM10_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCM10_DROME
• UniProt AC: Q9VIE6
• Protein Name: Protein MCM10 homolog
• Gene Name: Mcm10
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 776
• Subcellular Localization: Nucleus.
• Protein Description: Proposed to be involved in DNA replication and to participate in the activation of the pre-replication complex (pre-RC). May be involved in chromosome condensation..
• Protein Sequence: MGPAQKSGTDISIDDEEEILALEKLLGAAENENTKSAESEKAKPTAPILVPKLREDNSFANAFTFEKIVKPEKQKNAAIIKEPELDSSDDEEVKNFLERKYNEYGSDINKRLKQQQENAYESKVAREVDQELKKSIHVVTSTPQPLKNPHNPIKRQSAVSTTFQRPPPVAAAVASTSQSSAPVSAVFTDPVFGLRMINPLVSSSLLQERMTGRKPVPFSGVAYHIERGDLAKDWVIAGALVSKNPVKNTKKGDPYSTWKLSDLRGEVKTISLFLFKEAHKSLWKTAEGLCLAVLNPTIFERRAGSSDVACLSIDSSQKVMILGQSKDLGTCRATKKNGDKCTSVVNLTDCDYCIFHVKQEYGKMSRRSELQSATAGRGINELRNKVLGKNEVFYGGQTFTAVPARKSAKLITKERDRLSMLAGYDVSPFAHTANHTSKPKTAEPTKIPYAERGGPVSRLAGGVEASRKQRVQDLERLRLLKEENERFEKKKQAEGHVLGSDNKKESEAGTPAVSMPTTPVPDKFKNRGFSFDASLTPKLSGSENFSFEINVGSRQAQNAKLKAAALLKKKPLEKINPNSTRGSESGKRRAIDELNEKFSSSAKRQKIDEDDRELMRKSRIEKIMAATSSHTNLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSASDRCKEQKHPLKVVDAEKRFFQCKDCGNRTTTVFKLPKQSCKNCKGSRWQRTAMIREKKILTGRETLSVRGDEETFMGCLAGSANLNLLVPDEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	IKEPELDSSDDEEVK ECCCCCCCCCHHHHH	48.57	25749252
88	Phosphorylation	KEPELDSSDDEEVKN CCCCCCCCCHHHHHH	49.07	25749252
142	Phosphorylation	SIHVVTSTPQPLKNP HEEEEECCCCCCCCC	19.31	21082442
368	Phosphorylation	YGKMSRRSELQSATA HHCCCCHHHHHHHHC	41.36	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCM10_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCM10_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCM10_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MCM10_DROME	Mcm10	physical	20498296

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-88, AND MASSSPECTROMETRY.
PubMed: 18327897