KDM4A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM4A_DROME
• UniProt AC: Q9V333
• Protein Name: Probable lysine-specific demethylase 4A
• Gene Name: Kdm4A
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 495
• Subcellular Localization: Nucleus .
• Protein Description: Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate (By similarity)..
• Protein Sequence: MSTRSSFADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMTIPAPICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERYDNWLKGQDMGCHPEEPGKICAAAPPTLNEYEKQENLRAAKSEEESPQKRGCSLAGNGCERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAPKRYDFNTEAVVRVKRLWNELPCPDRGANLLTNGVVKNTKRMRFQTKVLTLDDED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
377	Phosphorylation	ENLRAAKSEEESPQK HHHHHHHCCCCCCCH	45.58	25749252
381	Phosphorylation	AAKSEEESPQKRGCS HHHCCCCCCCHHCCC	35.59	27626673
388	Phosphorylation	SPQKRGCSLAGNGCE CCCHHCCCCCCCCCC	24.87	27626673
409	Phosphorylation	EDVDDKASVSSYSSC CCCCCCHHHHHHHHH	28.42	22817900
412	Phosphorylation	DDKASVSSYSSCRQL CCCHHHHHHHHHHHC	27.21	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDM4A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM4A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM4A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H32_HUMAN	HIST2H3C	physical	19061644
HP1_DROME	Su(var)205	physical	19061644
ECR_DROME	EcR	physical	24100631

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND MASSSPECTROMETRY.
PubMed: 18327897