SUV39_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUV39_DROME
• UniProt AC: P45975
• Protein Name: Histone-lysine N-methyltransferase Su(var)3-9
• Gene Name: Su(var)3-9
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 635
• Subcellular Localization: Nucleus. Chromosome, centromere. Associates with centromeric constitutive heterochromatin.
• Protein Description: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation..
• Protein Sequence: MATAEAQIGVNRNLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYETYIAKITTELEKQLEALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGRDNCRKVLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	VSKLTPLSPEVISRQ HHHCCCCCHHHHCCE	21.88	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUV39_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUV39_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUV39_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KARG_DROME	Argk	physical	14605208
DTX_DROME	dx	physical	14605208
HSP26_DROME	Hsp26	physical	14605208
HSP27_DROME	Hsp27	physical	14605208
TCTP_DROME	Tctp	physical	14605208
EIF3L_DROME	CG5642	physical	14605208
RS3_DROME	RpS3	physical	14605208
PH4H_DROME	Hn	physical	14605208
EIF3I_DROME	Trip1	physical	14605208
HP1_DROME	Su(var)205	physical	11867540
HP1_DROME	Su(var)205	physical	22365829
HDAC1_DROME	Rpd3	physical	11571273
DDX17_DROME	Rm62	physical	21674064
SUV37_DROME	Su(var)3-7	physical	11867540

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.