DTX_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DTX_DROME
• UniProt AC: Q23985
• Protein Name: Protein deltex
• Gene Name: dx
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 738
• Subcellular Localization: Cytoplasm .
• Protein Description: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway..
• Protein Sequence: MASSAGSAASGSVVPGGGGSAASSCATMALSTAGSGGPPVNHAHAVCVWEFESRGKWLPYSPAVSQHLERAHAKKLTRVMLSDADPSLEQYYVNVRTMTQESEAETAGSGLLTIGVRRMFYAPSSPAGKGTKWEWSGGSADSNNDWRPYNMHVQCIIEDAWARGEQTLDLCNTHIGLPYTINFCNLTQLRQPSGPMRSIRRTQQAPYPLVKLTPQQANQLKSNSASVSSQYNTLPKLGDTKSLHRVPMTRQQHPLPTSHQVQQQQHQHQHQQQQQQQHHHQHQQQQHQQQQQHQMQHHQIHHQTAPRKPPKKHSEISTTNLRQILNNLNIFSSSTKHQSNMSTAASASSSSSSASLHHANHLSHAHFSHAKNMLTASMNSHHSRCSEGSLQSQRSSRMGSHRSRSRTRTSDTDTNSVKSHRRRPSVDTVSTYLSHESKESLRSRNFAISVNDLLDCSLGSDEVFVPSLPPSSLGERAPVPPPLPLHPRQQQQQQQQQQQLQMQQQQQAQQQQQQSIAGSIVGVDPASDMISRFVKVVEPPLWPNAQPCPMCMEELVHSAQNPAISLSRCQHLMHLQCLNGMIIAQQNEMNKNLFIECPVCGIVYGEKVGNQPIGSMSWSIISKNLPGHEGQNTIQIVYDIASGLQTEEHPHPGRAFFAVGFPRICYLPDCPLGRKVLRFLKIAFDRRLLFSIGRSVTTGREDVVIWNSVDHKTQFNMFPDPTYLQRTMQQLVHLGVTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
409	Phosphorylation	RSRSRTRTSDTDTNS CCCCCCCCCCCCCCH	30.27	27626673
410	Phosphorylation	SRSRTRTSDTDTNSV CCCCCCCCCCCCCHH	34.91	21082442
425	Phosphorylation	KSHRRRPSVDTVSTY HHHCCCCCCCHHHHH	30.71	11861487

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DTX_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DTX_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DTX_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERM_DROME	term	physical	14605208
RG92B_DROME	RhoGAP92B	physical	14605208
CNN_DROME	cnn	physical	14605208
ACOX1_DROME	CG5009	physical	14605208
ARI2_DROME	ari-2	physical	14605208
ARRA_DROME	Arr1	physical	14605208
PP2A_DROME	mts	physical	14605208
SRC64_DROME	Src64B	physical	14605208
RAB26_DROME	Rab26	physical	14605208
SRC42_DROME	Src42A	physical	14605208
NOTCH_DROME	N	genetic	1592246
NLE_DROME	Nle	genetic	9857191
SUDX_DROME	Su(dx)	genetic	8150285
SUDX_DROME	Su(dx)	genetic	9832525
SUDX_DROME	Su(dx)	genetic	12648496
SUH_DROME	Su(H)	genetic	16395579
SUH_DROME	Su(H)	genetic	16307735
SCA_DROME	sca	genetic	18073442
HSP7D_DROME	Hsc70-4	genetic	10569241
DL_DROME	Dl	genetic	16395579
HLES_DROME	H	genetic	10842054
NOTCH_DROME	N	physical	24855951
NOTCH_DROME	N	physical	7671825
DTX_DROME	dx	physical	11861487
DTX_DROME	dx	physical	7671825

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, AND MASSSPECTROMETRY.
PubMed: 18327897