RG92B_DROME - dbPTM
RG92B_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RG92B_DROME
UniProt AC Q9VDS5
Protein Name Rho GTPase-activating protein 92B
Gene Name RhoGAP92B
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 740
Subcellular Localization
Protein Description GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state..
Protein Sequence MKRQFAKIKIAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPALSGGGGSGSGSSEEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRLKNILDKEIQEISTLKRNVSRTLQEYTSLKRSHEAAIRLEEPAAKVNHIKSQQEECELKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDTIQGTEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEKPAKPPLPNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDSIGSFKLKPDVPQKPLLPKRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLRQENGETNGTREVSSTTKENNHNHDPPATAADQNQQQAQPQVTTPISPNSFQTPKRPTVPAPPPPTNWKSSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58PhosphorylationALSGGGGSGSGSSEE
HHCCCCCCCCCCHHH		32.8219429919
60PhosphorylationSGGGGSGSGSSEEQD
CCCCCCCCCCHHHHH		36.8819429919
62PhosphorylationGGGSGSGSSEEQDKR
CCCCCCCCHHHHHHH		35.9519429919
63PhosphorylationGGSGSGSSEEQDKRT
CCCCCCCHHHHHHHH		48.9919429919
323PhosphorylationQDPHVIGSILKLYLR
CCHHHHHHHHHHHHH		17.3921082442
469PhosphorylationKLFVEGKSKSNSSNE
EEEEECCCCCCCCCC		52.7722817900
471PhosphorylationFVEGKSKSNSSNENL
EEECCCCCCCCCCCC		49.3819429919
473PhosphorylationEGKSKSNSSNENLDR
ECCCCCCCCCCCCCC		41.4519429919
474PhosphorylationGKSKSNSSNENLDRN
CCCCCCCCCCCCCCC		53.0319429919
483PhosphorylationENLDRNDSEVMESPR
CCCCCCHHHHHHCCC		35.3219429919
488PhosphorylationNDSEVMESPRYGTLR
CHHHHHHCCCCCCCC		9.1519429919
593PhosphorylationFGLDNLPSPTADRKS
ECCCCCCCCCCCCCC		37.7419429919
595PhosphorylationLDNLPSPTADRKSTD
CCCCCCCCCCCCCCC		45.5919429919
600PhosphorylationSPTADRKSTDSIGSF
CCCCCCCCCCCCCCC		38.0419429919
601PhosphorylationPTADRKSTDSIGSFK
CCCCCCCCCCCCCCC		36.4819429919
603PhosphorylationADRKSTDSIGSFKLK
CCCCCCCCCCCCCCC		29.0119429919
606PhosphorylationKSTDSIGSFKLKPDV
CCCCCCCCCCCCCCC		19.9619429919
624PhosphorylationPLLPKRPTVLGVGVP
CCCCCCCCEEEECCC		32.1819429919
637PhosphorylationVPKADGKSDDEGGTT
CCCCCCCCCCCCCCC		56.6819429919
643PhosphorylationKSDDEGGTTPTQATI
CCCCCCCCCCCEEEE		40.2219429919
644PhosphorylationSDDEGGTTPTQATID
CCCCCCCCCCEEEEE		27.8419429919
646PhosphorylationDEGGTTPTQATIDNG
CCCCCCCCEEEEECC		28.8319429919
649PhosphorylationGTTPTQATIDNGNGS
CCCCCEEEEECCCCE		21.0319429919
656PhosphorylationTIDNGNGSVRFKTEH
EEECCCCEEEEEHHH		17.7019429919
712PhosphorylationQAQPQVTTPISPNSF
HCCCCCCCCCCCCCC		21.5519429919
715PhosphorylationPQVTTPISPNSFQTP
CCCCCCCCCCCCCCC		21.1619429919
718PhosphorylationTTPISPNSFQTPKRP
CCCCCCCCCCCCCCC		23.3219429919
721PhosphorylationISPNSFQTPKRPTVP
CCCCCCCCCCCCCCC		28.8519429919
738PhosphorylationPPPTNWKSSD-----
CCCCCCCCCC-----		31.2118327897
739PhosphorylationPPTNWKSSD------
CCCCCCCCC------		43.5418327897
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RG92B_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RG92B_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RG92B_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RL4_DROMERpL4physical
14605208
NANOS_DROMEnosphysical
14605208
ELOA1_DROMEEloAphysical
14605208
DTBP1_DROMEDysbphysical
14605208
TBB1_DROMEbetaTub56Dphysical
14605208
60A_DROMEgbbgenetic
21041451
CDC42_DROMECdc42physical
23468526
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RG92B_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469; SER-473; SER-715;THR-721; SER-738 AND SER-739, AND MASS SPECTROMETRY.
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-593 AND THR-595, ANDMASS SPECTROMETRY.

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