dbPTM

SUH_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SUH_DROME
UniProt AC	P28159
Protein Name	Suppressor of hairless protein
Gene Name	Su(H)
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	594
Subcellular Localization	Nucleus . Cytoplasm . In imaginal disk, at the onset of differentiation of socket cell, it is also present in the cytoplasm.
Protein Description	Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. [PubMed: 21262215]
Protein Sequence	MKSYSQFNLNAAAPPAIAYETTVVNPNGSPLDPHQQQQQQSQDMPHFGLPGPQPPSSQQQQQQLQVHHQQQQQQQQQQQQQQHQQQMQMSLLPGPYRPHIEEKKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIYLFGSGWRRRYEEMLQQGEGEQGAQLCAFIGIGSSDQDMQQLDLNGKQYCAAKTLFISDSDKRKHFMLSVKMFYGNGHDIGVFNSKRIKVISKPSKKKQSLKNADLCIASGTNVALFNRLRSQTVSTRYLHVENGHFHASSTQWGAFTIHLLDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQMALLEADDPVSQLHKCAFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMINDGACWTIISTDKAEYQFYEGMGPVASPVTPVPIVNSLNLNGGGDVAMLELSGDNFTPHLQVWFGDVEAETMYRCTETLLCVVPEISQFRGEWLWVRQPTQVPISLVRNDGIIYATGLTFTYTPEPGPRPHCNTQAEDVMRARQNNNNNNITSISNNNNSNNAGSPAAGGGLQQQQQQHQALPSISEVQWNSHGSGLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of SUH_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SUH_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SUH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SUH_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCNB_DROME	CycB	physical	14605208
HLES_DROME	H	physical	14605208
HLES_DROME	H	physical	15710747
ASF1_DROME	asf1	physical	19782028
HDAC1_DROME	Rpd3	physical	19782028
KDM5_DROME	lid	physical	19782028
KDM5_DROME	lid	physical	20231316
HLES_DROME	H	physical	20231316
MAML1_HUMAN	MAML1	physical	11390662
NOTC1_HUMAN	NOTCH1	physical	11390662
ARM_DROME	arm	genetic	19668359
NOTCH_DROME	N	genetic	11071771
VG_DROME	vg	genetic	9501029
MAM_DROME	mam	genetic	8913755
MAM_DROME	mam	genetic	10545243
VEIN_DROME	vn	genetic	9383058
CTBP_DROME	CtBP	genetic	12154126
HLES_DROME	H	genetic	11071771
HLES_DROME	H	genetic	9383058
HLES_DROME	H	genetic	11378391
HLES_DROME	H	genetic	22125648
ESM7_DROME	E(spl)m7-HLH	genetic	10903180
ESM8_DROME	E(spl)m8-HLH	genetic	10903180
GROU_DROME	gro	genetic	12154126
GROU_DROME	gro	genetic	9383058
CI_DROME	ci	genetic	12954721
NOTCH_DROME	N	physical	11390662
NOTCH_DROME	N	physical	15123610
NOTCH_DROME	N	physical	10898989
NOTCH_DROME	N	physical	25588307
MAM_DROME	mam	physical	11390662
MAM_DROME	mam	physical	10898989
ASF1_DROME	asf1	physical	17925233
HLES_DROME	H	physical	25242320
HLES_DROME	H	physical	24282610
HLES_DROME	H	physical	7958912
HLES_DROME	H	physical	27404588
HLES_DROME	H	physical	11378391
HLES_DROME	H	physical	12154126
HLES_DROME	H	physical	21737682
HLES_DROME	H	physical	25650119
HLES_DROME	H	physical	25588307

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SUH_DROME

Related Literatures of Post-Translational Modification