dbPTM

ASF1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASF1_DROME
UniProt AC	Q9V464
Protein Name	Histone chaperone asf1
Gene Name	asf1
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	218
Subcellular Localization	Nucleus . Chromosome . Localizes to multiple sites on polytene chromosomes including transcriptionally active developmental puffs, the chromocenter and the histone gene cluster (PubMed:12381660). Localizes to active foci of DNA replication throughout
Protein Description	Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Plays a role in the formation of silent heterochromatin..
Protein Sequence	MAKVHITNVVVLDNPSSFFNPFQFELTFECIEELKEDLEWKMIYVGSAESEEHDQVLDTIYVGPVPEGRHIFVFQADPPDVSKIPEPDAVGVTIVLLTCSYRGQEFVRVGYYVNNDYADPEMRENPPTKPLFEKLTRNILASKPRVTRFKINWDYGHINGNGNGVENGHQDEMATDGPSTSEAASAVIHPEDDNSLAMPMENGIKALNENSNSLAMEC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
211	Phosphorylation	IKALNENSNSLAMEC HHHHHHCCCCCCCCC	22.93	19429919
213	Phosphorylation	ALNENSNSLAMEC-- HHHHCCCCCCCCC--	19.82	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ASF1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ASF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HIRA_DROME	Hira	physical	19782028
CAF1_DROME	Caf1	physical	19782028
MCM2_DROME	Mcm2	physical	19782028
EAF3_DROME	MRG15	physical	19782028
KDM5_DROME	lid	physical	19782028
CAF1_DROME	Caf1	physical	11533245
DONS_DROME	hd	physical	22036573
KDM5_DROME	lid	genetic	19782028
BRM_DROME	brm	genetic	12381660
OSA_DROME	osa	genetic	12381660
SUH_DROME	Su(H)	physical	17925233
BRM_DROME	brm	physical	12381660
HLES_DROME	H	physical	17925233
GROU_DROME	gro	physical	17925233

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASF1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211 AND SER-213, ANDMASS SPECTROMETRY.	18327897 [Abstract]