| UniProt ID | EAF3_DROME | |
|---|---|---|
| UniProt AC | Q9Y0I1 | |
| Protein Name | NuA4 complex subunit EAF3 homolog | |
| Gene Name | MRG15 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 424 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV.. | |
| Protein Sequence | MGEVKPAKVENYSTGTDANTLFVDGERVLCFHGPLIYEAKVLKTKPDATPVEYYIHYAGWSKNWDEWVPENRVLKYNDDNVKRRQELARQCGERSKKDNKKGSAKAKKMEQMRNESRASTPSKDSNTSQSTASSTPTTSAGPGSKSEAGSTGTTTTNSTANSTTSRAHRKSTQSTPSTARPGTPSDKKEDPAAAETTEEEGPVAPKKKRMSEQRPSLTGSDVAEKPLPPTTTPSTPTTEPAPCVESEEAYAAKVEVKIKIPDELKHYLTDDWYAVVREHKLLELPAKVTVQQISEQYLAHKKSVKSTSASKEVAINDVLDGIVEYFNVMLGSQLLYKFERTQYADVMQKHPDTPLSELYGSFHLLRLFVRLGSMLSYSALDQQSMQNLLTHVQDFLKFLVKNSSIFFSMSNFINVDPEYVRNAQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Phosphorylation | YEAKVLKTKPDATPV EEEEEEECCCCCCCE | 43.58 | 22817900 | |
| 119 | Phosphorylation | MRNESRASTPSKDSN HHHHHHCCCCCCCCC | 39.48 | 18327897 | |
| 120 | Phosphorylation | RNESRASTPSKDSNT HHHHHCCCCCCCCCC | 30.51 | 22668510 | |
| 174 | Phosphorylation | AHRKSTQSTPSTARP CCHHHCCCCCCCCCC | 42.23 | 22668510 | |
| 175 | Phosphorylation | HRKSTQSTPSTARPG CHHHCCCCCCCCCCC | 16.08 | 18327897 | |
| 177 | Phosphorylation | KSTQSTPSTARPGTP HHCCCCCCCCCCCCC | 34.48 | 19429919 | |
| 178 | Phosphorylation | STQSTPSTARPGTPS HCCCCCCCCCCCCCC | 28.08 | 19429919 | |
| 183 | Phosphorylation | PSTARPGTPSDKKED CCCCCCCCCCCCCCC | 23.46 | 19429919 | |
| 185 | Phosphorylation | TARPGTPSDKKEDPA CCCCCCCCCCCCCCH | 63.00 | 19429919 | |
| 196 | Phosphorylation | EDPAAAETTEEEGPV CCCHHHCCCCCCCCC | 34.48 | 19429919 | |
| 197 | Phosphorylation | DPAAAETTEEEGPVA CCHHHCCCCCCCCCC | 32.67 | 19429919 | |
| 211 | Phosphorylation | APKKKRMSEQRPSLT CCCCCCCCCCCCCCC | 34.31 | 22817900 | |
| 216 | Phosphorylation | RMSEQRPSLTGSDVA CCCCCCCCCCCCCCC | 40.53 | 19429919 | |
| 218 | Phosphorylation | SEQRPSLTGSDVAEK CCCCCCCCCCCCCCC | 38.69 | 19429919 | |
| 235 | Phosphorylation | PPTTTPSTPTTEPAP CCCCCCCCCCCCCCC | 26.34 | 18327897 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EAF3_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EAF3_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EAF3_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PP2A_DROME | mts | physical | 14605208 | |
| LST8_DROME | Lst8 | physical | 22036573 | |
| C6A13_DROME | Cyp6a13 | physical | 22036573 | |
| JMJD6_DROME | PSR | physical | 22036573 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119; THR-175; THR-183;THR-196; THR-197; SER-211 AND THR-235, AND MASS SPECTROMETRY. | |
