dbPTM

HSP27_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSP27_DROME
UniProt AC	P02518
Protein Name	Heat shock protein 27
Gene Name	Hsp27
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	213
Subcellular Localization
Protein Description
Protein Sequence	MSIIPLLHLARELDHDYRTDWGHLLEDDFGFGVHAHDLFHPRRLLLPNTLGLGRRRYSPYERSHGHHNQMSRRASGGPNALLPAVGKDGFQVCMDVSQFKPNELTVKVVDNTVVVEGKHEEREDGHGMIQRHFVRKYTLPKGFDPNEVVSTVSSDGVLTLKAPPPPSKEQAKSERIVQIQQTGPAHLSVKAPAPEAGDGKAENGSGEKMETSK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSIIPLLHL ------CCHHHHHHH	29.26	23607784
49	Phosphorylation	RRLLLPNTLGLGRRR HHHHCCCCCCCCCCC	21.91	21082442
58	Phosphorylation	GLGRRRYSPYERSHG CCCCCCCCCCCCCCC	21.13	22817900
75	Phosphorylation	NQMSRRASGGPNALL HHHHHHHCCCCCCCC	42.33	21082442
205	Phosphorylation	DGKAENGSGEKMETS CCCCCCCCCCCCCCC	56.19	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HSP27_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HSP27_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSP27_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED19_DROME	MED19	physical	14605208
LIS1_DROME	Lis-1	physical	14605208
TAD2B_DROME	Ada2b	physical	14605208
REF2P_DROME	ref(2)P	physical	22036573
HSP68_DROME	Hsp68	physical	22036573
HSP72_DROME	Hsp70Ba	physical	22036573
QTRT2_DROME	CG3434	physical	22036573
TGT_DROME	Tgt	physical	22036573
RS27A_DROME	RpS27A	physical	24292889

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSP27_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, AND MASSSPECTROMETRY.	18327897 [Abstract]
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells."; Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.; Mol. Biosyst. 3:275-286(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75, AND MASSSPECTROMETRY.	17372656 [Abstract]