dbPTM

QTRT2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	QTRT2_DROME
UniProt AC	Q9VSZ6
Protein Name	Queuine tRNA-ribosyltransferase accessory subunit 2 {ECO:0000255\|HAMAP-Rule:MF_03043}
Gene Name	CG3434
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	418
Subcellular Localization	Cytoplasm .
Protein Description	Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)..
Protein Sequence	MKFAIESISKNSGRLGQLRIRDGGPEFKTPLLLQTTKGGSIPWLSADVFETHVSRKPQVLQFTLSTMEQMTEALTHWNSGGGRGLSDYVGLPGHLNILLLRDPCETTPSGGNDRDILPLFTRRGKESLSSERYMEIVASFKPDMYEGLCDADTNLESAKKRVQKSVDRTEKFMQYIYEHRGKVNSTLLAPIVGGYNTFARTQSIKHAREQPAGSYGGYIFEGFHANGLSATTLDTSKLLPIVEHCVKQLEEDKPKILPGAYTPLTVLELIQQGIDVFDTSYAYCASLNFKALSFSFVQDAVEHVPFLDITDEAIKEDFTPPLSNCNCLTCQKHTRAYLHHLYKTNELLGPILLMVHNLYHYMAFFEKIRESVAKDTLPQLTELVRNQNGKTQVDYSIAANTKVISKATMGKGFAAAAV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
127	Phosphorylation	FTRRGKESLSSERYM HCCCCCCCCCCHHHH	22817900
195	Phosphorylation	LAPIVGGYNTFARTQ ECHHHCCCCHHHCHH	21082442
197	Phosphorylation	PIVGGYNTFARTQSI HHHCCCCHHHCHHHH	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of QTRT2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of QTRT2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of QTRT2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of QTRT2_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of QTRT2_DROME

Related Literatures of Post-Translational Modification