HSP26_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP26_DROME
• UniProt AC: P02517
• Protein Name: Heat shock protein 26
• Gene Name: Hsp26
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 208
• Protein Sequence: MSLSTLLSLVDELQEPRSPIYELGLGLHPHSRYVLPLGTQQRRSINGCPCASPICPSSPAGQVLALRREMANRNDIHWPATAHVGKDGFQVCMDVAQFKPSELNVKVVDDSILVEGKHEERQDDHGHIMRHFVRRYKVPDGYKAEQVVSQLSSDGVLTVSIPKPQAVEDKSKERIIQIQQVGPAHLNVKANESEVKGKENGAPNGKDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLSTLLSL ------CCHHHHHHH	30.90	19429919
4	Phosphorylation	----MSLSTLLSLVD ----CCHHHHHHHHH	15.09	19429919
5	Phosphorylation	---MSLSTLLSLVDE ---CCHHHHHHHHHH	36.69	19429919
8	Phosphorylation	MSLSTLLSLVDELQE CCHHHHHHHHHHHCC	29.47	19429919
18	Phosphorylation	DELQEPRSPIYELGL HHHCCCCCCHHHCCC	26.77	19429919
31	Phosphorylation	GLGLHPHSRYVLPLG CCCCCCCCCCEEECC	29.74	22817900
39	Phosphorylation	RYVLPLGTQQRRSIN CCEEECCCCCCCCCC	29.25	22817900
44	Phosphorylation	LGTQQRRSINGCPCA CCCCCCCCCCCCCCC	23.69	28490779
52	Phosphorylation	INGCPCASPICPSSP CCCCCCCCCCCCCCC	22.86	28490779
57	Phosphorylation	CASPICPSSPAGQVL CCCCCCCCCCHHHHH	44.54	28490779
58	Phosphorylation	ASPICPSSPAGQVLA CCCCCCCCCHHHHHH	12.15	28490779
111	Phosphorylation	NVKVVDDSILVEGKH CEEEECCCEEECCCC	17.23	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSP26_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSP26_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP26_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADRL_DROME	AdipoR	physical	14605208
ETS4_DROME	Ets98B	physical	14605208
NICA_DROME	nct	physical	14605208
RM19_DROME	mRpL19	physical	14605208
HSP27_DROME	Hsp27	physical	22036573
REF2P_DROME	ref(2)P	physical	22036573
YPL1_DROME	CG15309	physical	22036573
DEFI8_DROME	CG11534	physical	22036573
JMJD6_DROME	PSR	physical	22036573
CP4E2_DROME	Cyp4e2	physical	22036573
TGT_DROME	Tgt	physical	22036573
NDE1_DROME	nudE	physical	22036573
QTRT2_DROME	CG3434	physical	22036573
RS27A_DROME	RpS27A	physical	24292889
OVO_DROME	ovo	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44; SER-52 AND SER-58,AND MASS SPECTROMETRY.
PubMed: 18327897