| UniProt ID | NICA_DROME | |
|---|---|---|
| UniProt AC | Q9VC27 | |
| Protein Name | Nicastrin {ECO:0000303|PubMed:10993067} | |
| Gene Name | Nct {ECO:0000312|FlyBase:FBgn0039234} | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 695 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.. | |
| Protein Sequence | MEMRLNAASIWLLILSYGATIAQGERTRDKMYEPIGGASCFRRLNGTHQTGCSSTYSGSVGVLHLINVEADLEFLLSSPPSPPYAPMIPPHLFTRNNLMRLKEAGPKNISVVLLINRTNQMKQFSHELNCPNQYSGLNSTSETCDASNPAKNWNPWGTGLLHEDFPFPIYYIADLDQVTKLEKCFQDFNNHNYETHALRSLCAVEVKSFMSAAVNTEVCMRRTNFINNLGGSKYCDPLEGRNVYATLYPRKPAIENNLETVHTNEKFILVTCRLDTTTMFDGVGLGAMDSLMGFAVFTHVAYLLKQLLPPQSKDLHNVLFVTFNGESYDYIGSQRFVYDMEKLQFPTESTGTPPIAFDNIDFMLDIGTLDDISNIKLHALNGTTLAQQILERLNNYAKSPRYGFNLNIQSEMSAHLPPTSAQSFLRRDPNFNALILNARPTNKYYHSIYDDADNVDFTYANTSKDFTQLTEVNDFKSLNPDSLQMKVRNVSSIVAMALYQTITGKEYTGTKVANPLMADEFLYCFLQSADCPLFKAASYPGSQLTNLPPMRYISVLGGSQESSGYTYRLLGYLLSQLQPDIHRDNCTDLPLHYFAGFNNIGECRLTTQNYSHALSPAFLIDGYDWSSGMYSTWTESTWSQFSARIFLRPSNVHQVTTLSVGIVVLIISFCLVYIISSRSEVLFEDLPASNAALFG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | N-linked_Glycosylation | ASCFRRLNGTHQTGC CHHHHHCCCCCCCCC | 52.05 | - | |
| 108 | N-linked_Glycosylation | LKEAGPKNISVVLLI HHHHCCCCEEEEEEE | 34.60 | - | |
| 116 | N-linked_Glycosylation | ISVVLLINRTNQMKQ EEEEEEEECCCHHHH | 44.70 | - | |
| 138 | N-linked_Glycosylation | PNQYSGLNSTSETCD CCCCCCCCCCCCCCC | 46.93 | - | |
| 381 | N-linked_Glycosylation | NIKLHALNGTTLAQQ HCEEECCCCCHHHHH | 46.69 | - | |
| 461 | N-linked_Glycosylation | NVDFTYANTSKDFTQ CEEEEEECCCCCCCC | 34.18 | - | |
| 489 | N-linked_Glycosylation | SLQMKVRNVSSIVAM HHHHHHCCHHHHHHH | 40.80 | - | |
| 585 | N-linked_Glycosylation | QPDIHRDNCTDLPLH CCCHHHCCCCCCCCE | 30.46 | - | |
| 609 | N-linked_Glycosylation | ECRLTTQNYSHALSP CEEEECCCCCCCCCC | 37.88 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NICA_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NICA_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NICA_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| UGGG_DROME | Ugt | physical | 15710747 | |
| NOTCH_DROME | N | genetic | 11782315 | |
| NOTCH_DROME | N | genetic | 11782316 | |
| NOTCH_DROME | N | genetic | 16145661 | |
| PEN2_DROME | pen-2 | physical | 20421416 | |
| APH1_DROME | aph-1 | physical | 20421416 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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