dbPTM

NDE1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDE1_DROME
UniProt AC	Q9VT70
Protein Name	Nuclear distribution protein nudE homolog
Gene Name	nudE
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	317
Subcellular Localization	Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Localizes to the interphase centrosome and to the mitotic spindle..
Protein Description	Required for centrosome duplication and formation and function of the mitotic spindle..
Protein Sequence	MESPPMFNSVEDECRYWKERSKQYHKEWTDVKQEYDEFVEQSREMEIEMDATLDQKQSIIKDLTAKLTMFERENESLKLKLESHGIDMSNMEKQLETVKKDRDTMKVYLRQLEQKNDDLERAHRILNESIENFEKMLDQAYEKNALLELEVDEKGLLQEKLQRLMDETRDLKQELNVKSRFTPVVNGTSVPTANDTNTVNSSMNSSASLPNGIVANGELVKHDNAVATRATSVSVNALNGSLVNRNEYNQQHSLKSDGDETEDVPREWSANAAATPLLPAIHTSGAGRTALLLAGCRVVWILQFSVIHKPQIRNPIT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
232	Phosphorylation	AVATRATSVSVNALN CCEECCEEEEHHHHC	16.06	21082442
234	Phosphorylation	ATRATSVSVNALNGS EECCEEEEHHHHCCC	14.93	21082442
253	Phosphorylation	NEYNQQHSLKSDGDE CCCCCCCCCCCCCCC	32.90	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDE1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NDE1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDE1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
LIS1_DROME	Lis-1	genetic	25908857
ZWILC_DROME	Zwilch	genetic	19417004

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDE1_DROME

Related Literatures of Post-Translational Modification