TCTP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCTP_DROME
• UniProt AC: Q9VGS2
• Protein Name: Translationally-controlled tumor protein homolog
• Gene Name: Tctp
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 172
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in calcium binding and microtubule stabilization..
• Protein Sequence: MKIYKDIITGDEMFADTYKMKLVDDVIYEVYGKLITRQGDDIKLEGANASAEEADEGTDITSESGVDVVLNHRLTECFAFGDKKSYTLYLKDYMKKVLAKLEEKSPDQVDIFKTNMNKAMKDILGRFKELQFFTGESMDCDGMVALVEYREINGDSVPVLMFFKHGLEEEKC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Acetylation	EMFADTYKMKLVDDV HHHHHHHHCCCHHHH	31.48	21791702
21	Acetylation	FADTYKMKLVDDVIY HHHHHHCCCHHHHHH	41.00	21791702
28	Phosphorylation	KLVDDVIYEVYGKLI CCHHHHHHHHHHHHH	10.13	19429919
31	Phosphorylation	DDVIYEVYGKLITRQ HHHHHHHHHHHHHCC	9.15	19429919
50	Phosphorylation	KLEGANASAEEADEG EEECCCCCHHHCCCC	35.70	22817900
58	Phosphorylation	AEEADEGTDITSESG HHHCCCCCCCCCCCC	23.37	30478224
61	Phosphorylation	ADEGTDITSESGVDV CCCCCCCCCCCCCCE	29.29	22817900
62	Phosphorylation	DEGTDITSESGVDVV CCCCCCCCCCCCCEE	30.05	29892262
84	Acetylation	CFAFGDKKSYTLYLK EEECCCCCEEEEEHH	54.13	21791702
91	Acetylation	KSYTLYLKDYMKKVL CEEEEEHHHHHHHHH	33.00	21791702
100	Acetylation	YMKKVLAKLEEKSPD HHHHHHHHHHHHCHH	52.88	21791702
104	Acetylation	VLAKLEEKSPDQVDI HHHHHHHHCHHHHHH	58.89	21791702
105	Phosphorylation	LAKLEEKSPDQVDIF HHHHHHHCHHHHHHH	36.67	22817900
113	Acetylation	PDQVDIFKTNMNKAM HHHHHHHHHHHHHHH	39.05	21791702
121	Acetylation	TNMNKAMKDILGRFK HHHHHHHHHHHHHHH	46.61	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCTP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCTP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCTP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYL1_DROME	ctp	physical	14605208
SAP47_DROME	Sap47	physical	14605208
C1GLT_DROME	C1GalTA	physical	14605208
CCNE_DROME	CycE	genetic	17301792
ATM_DROME	tefu	genetic	24352200
RHEB_DROME	Rheb	physical	17301792
RPB1_DROME	RpII215	physical	27687497
RAD50_DROME	rad50	physical	24352200
BRM_DROME	brm	physical	27687497
ATM_DROME	tefu	physical	24352200

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; THR-58 AND THR-61,AND MASS SPECTROMETRY.
PubMed: 18327897

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY.
PubMed: 17372656