ATM_DROME - dbPTM
ATM_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATM_DROME
UniProt AC Q5EAK6
Protein Name Serine/threonine-protein kinase ATM
Gene Name tefu
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 2767
Subcellular Localization Nucleus . Chromosome, telomere.
Protein Description Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin-modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV..
Protein Sequence MSALLNEIQRILGDLQSGKAASRNKGIQQLDEKLSSCREDLDKLFLSKTSDISWTTIFEASKEALFKQAGNLEDVNEKVFKTLAGKNYLYDNVLEKITQFNLEAGSQTSGNGHFLAKTSIFSAFEDGIKMRVVVKYFGDRILSLLEKGIYSSVSYVRDLKINEYSRILSYLFELNVDMDEVLRTRILKCITRTVSLAKDRVQLHVDLVEYLPELSSFALSAFGARKTEIVRVYLIFASELAVNYNHQLNVHMQEILPKLCEYHDEDAFRDDTRNLFFQCVSKSLHSMYLKMDMCDFNTLGVPVHEKWPQTLLRLKTIVNVEIRKNSWARCKNALLSNNKFSDPFIKMSALAMYIVLWHLETKKADENGEGDAPKKIPKPADKMETIFSLIDKKENTFNDVWLAIFTEILQLSSVILNVANYQMALTTVAEIMQMYGNAKNLRNLRLCLAHLLTKEQELLHSKSIREDFLGELWSQMANQLISETTTNSEEIKEKQLVLQMLIRHNKLNQKLSSTLLNNIISNEMLKRNECLATIREIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQLQADTFAISIINFLDVQQLRQISQSEHIVPSTERNLLAYKYNEQLICFDKDYATPFESITHIQSETKNCLIQSNYDCLMRGLNFEIAKENKPAAIIKNLNSLLKLICTMERLLHYKVFDADTYTGCPLIKRIGLYLSHIEFQLKANGAEILDKSDLPEILRLEIYVLDVFRTNLVLLDYLERQPIEMLVEFVGAALKLHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRDEAFEHIVKVTMRWHPQDVLIVTKMLCSCQTISEASSSWLVSKLKTLFQQHHQDAELMDKVVQHMPTIFYFVRHKENHLDDMLMALNSLLRIAIKKSYTSNLTAKIVRCVGLIAQRCPDIYLLENFAVICKSTAKFITMPTLEVRFATLFTFTILLESNCVTSDAIGHSRTHWDFCQELYESIEFKKLTYNNEDAIQNSNALIVQMLIAIFLRSSFHQEIALKELLHHCALRRLTEREFISLQSMSSCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTEDIERCSKSISEELALPILASFLLIKNSSCSESEGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVISMLHDPQEMMRLFGSLAICNRTASWYSLSGESLFKCLNFHIDPEMRPSMDSRIQSMTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFLYCEVADAVYDAARKNETIVTQCSFFVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQNHFGDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHINLNSFLEETTDCEFLKPLREDCKSSQPNIDRADVANYLRSFLLSPTPERLRDLRTYIAEHKDKVQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCLAQIGPLKISTVSYYFQTDFEAFEKSNGEPMEAFLGVVCHSLDTSLFQFDPKTHEGLVSVAIQVVNSKPGSNIMERYKNLRIFADKSTASTFLHSNKQIRRIDWLSILKATKSLSYEPWMCAFVSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIKLLLENSLEHVESLSQMLDYFFEGFTSSTAPNSQEIFRNKRAIKKFLHICEYIRIFNNWTIPINLSNVVMASNHCQAYFLSIMYLELWACSESPKSKADFLDNECFQDGAKKAYESIGCLDAIPGFVNPMRSRLDFLGHGSNLSTILLESDHLDRASGQLCIDIMKGNGLWSFAKLQQHQNIEPDYEIFWRLGQWDSLTDPKHQQNQTVVRTSLDLEQEFKRHHFVALRSIGQREEENSLSAIEQAYSCVRDILMEISVECLQSVYKYLTWLCSLQQAEDFCQIQFGTQLDPASTTKIFRKWQTELELKYGNFSCKEYVIAHQIALLKLAGTRASRRMSEFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIKISVLLEDAEINLKMGNQQIAKAILDYVTNNNEFVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQLDAYASKQRTAAYATIAKYADREYQQLHDYRHSQEYQTLKDIIEQNRQTAEKVTQRENQDRRVISVQMKRYASLDEQQLNQIEEKLTEYLRLALTNYMAYCRLDSGFSSAAIYRIISLWFTNATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHLDGENSNTERSGIARKIIAMICEKNGTAGECSKQLESLLPALITFANEGKTNDNRPVSDSVRNKQFDKVRRWRNLNAVHCPTLELPVMPSKEYSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQSPQQSGEESVNLVAQRALLLVQNKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGWDPHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2197PhosphorylationISVQMKRYASLDEQQ
EEEHHHHHHCCCHHH		8.6019429919
2199PhosphorylationVQMKRYASLDEQQLN
EHHHHHHCCCHHHHH		27.6719429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATM_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATM_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATM_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATR_DROMEmei-41genetic
16203987
ATR_DROMEmei-41genetic
16648644
ATR_DROMEmei-41genetic
16710445
ATR_DROMEmei-41genetic
22024169
TOP2_DROMETop2genetic
25340516
RAD50_DROMErad50genetic
16648644
RAD50_DROMErad50genetic
18408079
HDAC1_DROMERpd3genetic
18408079
ATRIP_DROMEmus304genetic
16203987
ATRIP_DROMEmus304genetic
16710445
NFKB1_DROMERelgenetic
23502677
TCTP_DROMETctpgenetic
24352200
DL_DROMEDlgenetic
18408079
CAV_DROMEcavgenetic
16710445
NEMF_DROMEClbngenetic
22964637
MPIP_DROMEstggenetic
18408079
RAD50_DROMErad50physical
24352200
TCTP_DROMETctpphysical
24352200
H2AV_DROMEHis2Avphysical
24352200
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATM_DROME

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Related Literatures of Post-Translational Modification

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