NEMF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEMF_DROME
• UniProt AC: Q9VBX1
• Protein Name: Nuclear export mediator factor NEMF homolog {ECO:0000250|UniProtKB:O60524}
• Gene Name: Clbn {ECO:0000312|EMBL:AAF56406.2, ECO:0000312|FlyBase:FBgn0259152}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 992
• Subcellular Localization: Nucleus .
• Protein Description: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Clbn/NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Clbn/NEMF is important for the stable association of l(3)76BDr/LTN1 to the complex (By similarity). Plays a role in regulating nuclear transport possibly through directly binding to both emb and cargo proteins. [PubMed: 16103875]
• Protein Sequence: MKTRFNTFDIICGVAELQKLVGWRVNQIYDVDNKTYLFRMQGTGAVEKVTLLIESGTRFHTTRFEWPKNMAPSGFSMKLRKHLKNKRLEKVQQMGSDRIVDFQFGTGDAAYHVILELYDRGNVILTDYELTTLYILRPHTEGENLRFAMREKYPVERAKQPTKELELEALVKLLENARNGDYLRQILTPNLDCGPAVIEHVLLSHGLDNHVIKKETTEETPEAEDKPEKGGKKQRKKQQNTKLEQKPFDMVNDLPILQQAVKDAQELIAEGNSGKSKGYIIQVKEEKPTENGTVEFFFRNIEFHPYLFIQFKNFEKATFESFMEAVDEFYSTQESQKIDMKTLQQEREALKKLSNVKNDHAKRLEELTKVQDVDRKKAELITSNQSLVDNAIRAVQSAIASQLSWPDIHELVKEAQANGDAVASSIKQLKLETNHISLMLSDPYDNDEDDDLKDPEVTVVDVDLALSAWANARRYYDMKRSAAQKEKKTVDASQKALKSAERKTQQTLKEVRTISNIVKARKVFWFEKFYWFISSENYLVIGGRDAQQNELIVKRYMRPKDIYVHAEIQGASSVIIQNPTGEEIPPKTLLEAGSMAISYSVAWDAKVVTNSYWVTSDQVSKTAPTGEYLATGSFMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDDQIDPNVKENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRSDSVNPEIEETKESEVVLDKILKKTDDEETTIILAGPSRKKQVSAKKTKEDKARAKQEAAKQEVPPVSSEPKNPSQVKRGQKGKLKKMKQKYKDQDDEEREIRMMILKSSGKEKPQASADKVVEKSESTKEYVKPEKSAAPKNPVELDDADEVPVGGDVDVLNSLTGQPHEGDELLFAIPVVAPYQALQNYKFKVKLTPGTGKRGKAAKLALNIFAKEKSCSAREKDLLKSIKEESLARNIPGKVKLSAPQLQKYHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
695	Phosphorylation	EVEHDLLSDNEDADS CCCCCCCCCCCCCCC	45.76	19429919
702	Phosphorylation	SDNEDADSNINLSEP CCCCCCCCCCCCCCC	41.13	22668510
707	Phosphorylation	ADSNINLSEPSSNTE CCCCCCCCCCCCCCC	42.86	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEMF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEMF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEMF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACOX1_DROME	CG5009	physical	14605208
HID_DROME	W	genetic	22964637

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.