EIF3L_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3L_DROME
• UniProt AC: Q9VTU4
• Protein Name: Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011}
• Gene Name: eIF3l {ECO:0000255|HAMAP-Rule:MF_03011}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 539
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation..
• Protein Sequence: MYGGDEYATNSDYYDDYAHTGDPQLDMEYERNYYAARMPDNVKYFLINFCQAIKEGNLYDIQNMYENTFPQISDHHFDKTAWPEEQEVAAIVDNDKVFLILYKELYYRHIHARIPGGPKLEQRINSFFNYCDFFNLIISAQNPVMLELPDIWLWELVDEFVYQFQNFAQYRARLTEKSQDEIQQLCVNHSNEWSILCILNVLHSLVDISNIKKQLEAISQGVDPQTVAGDFGKLSFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKKSAYSHIPACQISTSYYVGFAYMMMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQMYHLLAICLVLHPQCIDESIQQVLREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPAVDAPMDDYVKDPMEHQLQVFMDEVRQQKDLPTTRSYLKLYTTLPLTKLASFIDPNASEDDVSKLLIRLLCFKHKMRNLVWSKGPSGLEGTFKSGSELDFYIDDDMIHIADTKVSHRYGDFFVRKILKFNDLNRKLKNINI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	YGGDEYATNSDYYDD CCCCCCCCCCCCCCC	34.06	19429919
11	Phosphorylation	GDEYATNSDYYDDYA CCCCCCCCCCCCCCC	23.72	19429919
13	Phosphorylation	EYATNSDYYDDYAHT CCCCCCCCCCCCCCC	14.49	19429919
432	Phosphorylation	QQKDLPTTRSYLKLY HCCCCCCCHHHHHHH	18.71	22817900
440	Phosphorylation	RSYLKLYTTLPLTKL HHHHHHHHHCCHHHH	32.09	27794539
441	Phosphorylation	SYLKLYTTLPLTKLA HHHHHHHHCCHHHHH	16.90	27794539
499	Phosphorylation	SGSELDFYIDDDMIH CCCEEEEEECCCEEE	11.78	25749252
526	Acetylation	FFVRKILKFNDLNRK HHHHHHHCHHHHCHH	45.66	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3L_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3L_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3L_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VDAC_DROME	porin	physical	14605208
RS3_DROME	RpS3	physical	14605208
EF1A1_DROME	Ef1alpha48D	physical	14605208
NUP54_DROME	Nup54	physical	14605208
EI3F1_DROME	CG9769	physical	22036573
EIF3A_DROME	eIF3-S10	physical	22036573
EI3D1_DROME	eIF-3p66	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.