VDAC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VDAC_DROME
• UniProt AC: Q94920
• Protein Name: Voltage-dependent anion-selective channel
• Gene Name: porin
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 282
• Subcellular Localization: Mitochondrion outer membrane.
• Protein Description: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules..
• Protein Sequence: MAPPSYSDLGKQARDIFSKGYNFGLWKLDLKTKTSSGIEFNTAGHSNQESGKVFGSLETKYKVKDYGLTLTEKWNTDNTLFTEVAVQDQLLEGLKLSLEGNFAPQSGNKNGKFKVAYGHENVKADSDVNIDLKGPLINASAVLGYQGWLAGYQTAFDTQQSKLTTNNFALGYTTKDFVLHTAVNDGQEFSGSIFQRTSDKLDVGVQLSWASGTSNTKFAIGAKYQLDDDASVRAKVNNASQVGLGYQQKLRDGVTLTLSTLVDGKNFNAGGHKIGVGLELEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAPPSYSDLGKQ ---CCCCCHHHHHHH	35.89	27794539
7	Phosphorylation	-MAPPSYSDLGKQAR -CCCCCHHHHHHHHH	30.60	27794539
19	Acetylation	QARDIFSKGYNFGLW HHHHHHHCCCCCEEE	55.45	21791702
27	Acetylation	GYNFGLWKLDLKTKT CCCCEEEEEECCCCC	36.85	21791702
31	Acetylation	GLWKLDLKTKTSSGI EEEEEECCCCCCCCC	47.87	21791702
56	Phosphorylation	ESGKVFGSLETKYKV CCCCEECEEEEEEEE	16.15	22668510
60	Acetylation	VFGSLETKYKVKDYG EECEEEEEEEEEECC	33.43	21791702
64	Acetylation	LETKYKVKDYGLTLT EEEEEEEEECCEEEE	40.87	21791702
106	Phosphorylation	EGNFAPQSGNKNGKF ECCCCCCCCCCCCCE	43.18	27794539
231	Phosphorylation	YQLDDDASVRAKVNN EECCCCCHHHHHCCC	21.09	27794539
240	Phosphorylation	RAKVNNASQVGLGYQ HHHCCCHHHCCCCCC	27.76	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VDAC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VDAC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VDAC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATC1_DROME	Ca-P60A	physical	22036573
ATPA_DROME	blw	physical	22036573
OST48_DROME	Ost48	physical	22036573
FAXC_DROME	fax	physical	22036573
ERD2_DROME	KdelR	physical	22036573
ATP5J_DROME	ATPsyn-Cf6	physical	22036573
ATPB_DROME	ATPsyn-beta	physical	22036573
RAB6_DROME	Rab6	physical	22036573
ARF1_DROME	Arf79F	physical	22036573
ACADM_DROME	CG12262	physical	22036573
KRH2_DROME	Kr-h2	physical	22036573
ATPK_DROME	CG4692	physical	22036573
ATPO_DROME	Oscp	physical	22036573
CISD2_DROME	CG1458	physical	22036573
ATPG_DROME	ATPsyn-gamma	physical	22036573
VATA2_DROME	Vha68-2	physical	22036573
SURF4_DROME	Surf4	physical	22036573
QCR9_DROME	ox	physical	22036573
AT5F1_DROME	ATPsyn-b	physical	22036573
PDI_DROME	Pdi	physical	22036573
MARF_DROME	Marf	genetic	20949033
CLU_DROME	clu	physical	26035866

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.