ATPG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATPG_DROME
• UniProt AC: O01666
• Protein Name: ATP synthase subunit gamma, mitochondrial
• Gene Name: ATPsyngamma {ECO:0000312|FlyBase:FBgn0020235}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 297
• Subcellular Localization: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein.
• Protein Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits..
• Protein Sequence: MMMQRTQLLLPLAMEATMLAQQQRGMATLKMISIRLKSVKNIQKITQSMKMVSAAKYARAERDLKAARPYGIGAQQFFEKTEIQPDEKAEPKKLLIAVTSDRGLCGAVHTGVARLIRGELAQDEANTKVFCVGDKSRAILSRLYGKNILMVANEVGRLPPTFLDASKIANEVLQTGYDYTEGKIVYNRFKSVVSYQCSTLPIFSGSTVEKSEKLAVYDSLDSDVVKSYLEFSLASLIFYTMKEGACSEQSSRMTAMDNASKNAGEMIDKLTLTFNRTRQAVITRELIEIISGAAALT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Acetylation	MKMVSAAKYARAERD HHHHHHHHHHHHHHH	38.88	21791702
88	Acetylation	TEIQPDEKAEPKKLL CCCCCCCCCCCCEEE	66.48	21791702
88	Ubiquitination	TEIQPDEKAEPKKLL CCCCCCCCCCCCEEE	66.48	31113955
128	Acetylation	AQDEANTKVFCVGDK CCCCCCCEEEEECHH	32.87	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATPG_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATPG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATPG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPK_DROME	CG4692	physical	22036573
ACADM_DROME	CG12262	physical	22036573
CCD1P_DROME	Cyp12d1-p	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.