| UniProt ID | KINH_DROME | |
|---|---|---|
| UniProt AC | P17210 | |
| Protein Name | Kinesin heavy chain | |
| Gene Name | Khc | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 975 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . | |
| Protein Description | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria.. | |
| Protein Sequence | MSAEREIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSGQGAIAIRGGGAVGGPSPLAQVNPVNS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSAEREIPA ------CCCCCCCCH | 38.55 | 19429919 | |
| 161 | Phosphorylation | DVSKVNLSVHEDKNR CHHHCCEEECCCCCC | 19.07 | 19429919 | |
| 264 | Phosphorylation | EAKNINKSLSALGNV HHHHHHHHHHHHHHH | 24.06 | 21082442 | |
| 428 | Phosphorylation | ALANMSASVAVNEQA HHHHCCHHHHHHHHH | 11.87 | 21082442 | |
| 724 | Phosphorylation | ELRSMFDSQMDELRE HHHHHHHHHHHHHHH | 19.01 | 19429919 | |
| 841 | Phosphorylation | KNVVNEESEEDGGSL HHCCCCCCCCCCCCH | 39.86 | 29892262 | |
| 975 | Phosphorylation | AQVNPVNS------- HHCCCCCC------- | 41.66 | 28490779 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KINH_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KINH_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KINH_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SINA_DROME | sina | physical | 14605208 | |
| KLC_DROME | Klc | physical | 22036573 | |
| A4_DROME | Appl | genetic | 11709151 | |
| DYHC_DROME | Dhc64C | genetic | 10564267 | |
| DCTN1_DROME | Gl | genetic | 10564267 | |
| KINH_DROME | Khc | physical | 21836017 | |
| KLC_DROME | Klc | physical | 27802167 | |
| KLC_DROME | Klc | physical | 27512046 | |
| TPM1_DROME | Tm1 | physical | 27802167 | |
| TPM4_DROME | Tm1 | physical | 27802167 | |
| MILT_DROME | milt | physical | 27512046 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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