| UniProt ID | TPM4_DROME | |
|---|---|---|
| UniProt AC | P49455 | |
| Protein Name | Tropomyosin-1, isoforms 33/34 | |
| Gene Name | Tm1 | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 518 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. | |
| Protein Description | Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.. | |
| Protein Sequence | MDAIKKKMQAMKVDKDGALERALVCEQEARDANTRAEKAEEEARQLQKKIQTVENELDQTQEALTLVTGKLEEKNKALQNAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLKSLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLIVEKERYCMIGDSLDEAFVDLIKGLEPFWNPRNPKPPTPKLPTPTPEELAAMEEARAAAEAAAAAEAEAAEAAAAAGEAGPDGAPAAPGEEKAPAKEPTPPKEPTPPPPPPPPFEYSIDLPPEGAEVPYVKNYEPPPPGSEPEPVPAAEGEAAPAAEGAAPPAEGAAPPAEGAVPPADGAAPPAEGAAPAAEGAAPPADGAAPPAEAAAAPADAAAPAAEAAPAEAPAAEATAAEAPPAEAAPAEAAPAAAEGEAPPA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 108 | Phosphorylation | RSEERLGSATAKLSE HHHHHHHHHHHHHHH | 27.34 | 22817900 | |
| 114 | Phosphorylation | GSATAKLSEASQAAD HHHHHHHHHHHHHHC | 30.34 | 21082442 | |
| 206 | Phosphorylation | VVGNNLKSLEVSEEK HHHHHCHHCCCCHHH | 32.69 | 22817900 | |
| 297 (in isoform 2) | Phosphorylation | - | 68.41 | 18327897 | |
| 298 | Phosphorylation | PRNPKPPTPKLPTPT CCCCCCCCCCCCCCC | 41.40 | 27794539 | |
| 303 | Phosphorylation | PPTPKLPTPTPEELA CCCCCCCCCCHHHHH | 50.67 | 28490779 | |
| 359 | Phosphorylation | KAPAKEPTPPKEPTP CCCCCCCCCCCCCCC | 54.00 | 27794539 | |
| 365 | Phosphorylation | PTPPKEPTPPPPPPP CCCCCCCCCCCCCCC | 49.90 | 27794539 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TPM4_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TPM4_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TPM4_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TPM1_DROME | Tm1 | physical | 14605208 | |
| TPM4_DROME | Tm1 | physical | 14605208 | |
| RS19B_DROME | RpS19b | physical | 14605208 | |
| MYSN_DROME | zip | physical | 22036573 | |
| MLC2_DROME | Mlc-c | physical | 22036573 | |
| EFHD2_DROME | Swip-1 | physical | 22036573 | |
| DNAT_DROME | Dat | physical | 22036573 | |
| STAN_DROME | stan | genetic | 12867499 | |
| OSKA_DROME | osk | genetic | 11454766 | |
| NAA25_DROME | psidin | genetic | 21406550 | |
| KINH_DROME | Khc | physical | 27802167 | |
| KINH_DROME | Khc | physical | 28028052 | |
| STAU_DROME | stau | physical | 28028052 | |
| OSKA_DROME | osk | physical | 28028052 | |
| TPM1_DROME | Tm1 | physical | 27396338 | |
| TPM4_DROME | Tm1 | physical | 27396338 | |
| TPM1_DROME | Tm1 | physical | 16752200 | |
| TPM4_DROME | Tm1 | physical | 16752200 | |
| TPM2_DROME | Tm2 | physical | 16752200 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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