STAN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAN_DROME
• UniProt AC: Q9V5N8
• Protein Name: Protocadherin-like wing polarity protein stan
• Gene Name: stan
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 3579
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields..
• Protein Sequence: MQTREFPQRPLGLLLVLLVVLLQSSLIKSYLIIVHEDTPPGTVIFNASVYKLGSERHYKINAHKSANFVHHLVSVNHKDGQIQLRKALKCDGIYYPNLFTFYVDSTSNRLRSIDYYSLPVRIFVSGHSCNEDRRIEQELHHHHYEEEDNTGYSKRRRRRSTQEMIQLNGNQLEEVFRQNSTEFRAGDLIFGDSFDNEMRHRILSRKRRAVGSPDPLHLQPALHRRISDAKQWISETYASYAIHTTDKWNQICLRRSQFINSLNAFLPRSVCQHCKVSFLDVNDERFAIEHQSRDLVASRDVCIAESMWKVSITFNIRCDRRDIVDSDHRLKIVYHHQEFNDTDIARRVRRELRNQSPYFEQALYVASVLEEQPAGAAVTTVRARDPEDSPVVYSMVSLLDSRSQSLFKVDSRTGVVTTSASLDRELMDVHYFRVVATDDSFPPRSGTTTLQVNVLDCNDHSPTFEAEQFEASIREGATVGSTVITLRATDQDIGKNAEIEYGIEAVTDGAGLAQDQEMPIFRIDSRSGVISTRSSLDRETSDSYHLLVTAADLASAQSERRTATASVQVKVLDDNDNYPQFSERTYTVQVPEDQWGGTEDNTVAHIRATDADQGNNAAIRYAIIGGNTQSQFSIDSMSGDVSLVKPLDYESVRSYRLVIRAQDGGSPSRSNTTQLLVNVIDANDNAPRFYTSQFQESVLENVPVGYNIIRVQAYDSDEGANAEITYSISERDDNFPLAVDPRTGWVQTIKPLDREEQGRFAFQVVAKDGGVPPKSASSSVVITVQDVNDNDPAFNPKYYEANVGEDQPPGTPVTTVTATDPDEDSRLHYEITTGNTRGRFAITSQNGRGLITIAQSLDYKQEKRFLLTVAATDSGGRSDTATVHINITDANNFAPIFENAPYSASVFEDAPVGTTVLVVSATDSDVGVNAQITYSLNEESINGLGSPDPFSINPQTGAIVTNAPLDRETTSGYLLTVTAKDGGNPSLSDTTDVEIGVTDVNDNAPAFKSPLYQASILEDALVGTSVIQVAASDPDVGLNGRIKYLLSDRDIEDGSFVIDPTSGTIRTNKGLDRESVAVFHLTAIAVDKGSPPLSSTVEVQIRLEDVNDSPPTFASDKITLYVPENSPVGSVVGEIHAHDPDEGVNAVVHYSIIGGDDSNAFSLVTRPGSERAQLLTMTELDYESTRKRFELVVRAASPPLRNDAHIEILVTDVNDNAPVLRDFQVIFNNFRDHFPSGEIGRIPAFDADVSDKLHYRILSGNNANLLRLNSSSGGLVLSPQLNTNVPKFATMEVSVSDGINEAKAIMQLSVRLITEDMLFNSVTVRLNEMTEEAFLSPLLNFFLDGLAAIIPCPKEHIFVFSIQDDTDVSSRILNVSFSARRPDVSHEEFYTPQYLQERVYLNRAILARLATVEVLPFDDNLCVREPCLNFEECLTVLKFGNASEFIHSDTVLFRPIYPVNTFACSCPEGFTGSKEHYLCDTEVDLCYSDPCQNGGTCVRREGGYTCVCPSTHTGQNCETGVGHLRPCPSETCEGGLSCLSNYPSSQPPPYTATCELRARAFGRNSFLTFESLKQRHRFNLKLRFATVQENGLLLYNGRYNELHDFIALEIHEGHVSFSFSLGDHSERISVIQEAKVSDGKWHQVEVVYLNRSVTLVLDNCDTAIALSGQLGDRWSCANRTTLKLDKRCSLLTETCHRFLDLTGPLQVGGLPRIPAHFPVTNRDFVGCISDLRIDDRFVDLNSYVADNGTLAGCPQKAPLCQSEPCFNGGTCREGWGTYSCECPEGYAGNSCQDNIPAPWRFSGDGSLSFNPLLRPIQLPWTTSFSLRTRQKEAFLLQIQIGQNSSAAVCLRQGVLYYIFDGEPMYLAGAFLSDGEWHRVEIRWQQGSEIHFSVDYGQRSGSVPMSQKVQGLYVGKIVMGSPDGSIGAVPEASPFEGCIQDVRIGAGQSVLSRPTIRENVEDGCESRAQCPDHCPNHSSCQSSWDLSTCECDSGYVGTDCAPICTVRPCASGVCRANTSLPRGYDCECNSSSRHGDYCEKELQQPCPGGWWGERVCGPCRCDLAQGYHPDCNKTTGQCYCKTNHYQPPNETACLSCDCYSIGSFSGACNPLTGQCECREGVIGRRCDSCSNPYAEVTLSGCEVVYDACPRSFAGGVWWPRTPLGGVAIEGCPPPARGKGQRSCDVQSGSWNTPDMYNCTSEPFVELRRQLSQLEKLELELNSFVAIKMAEQLRKACEAVDRRGASKDQKISGNGRPNRRYKMESSFLLSNGGNVWSHELEMDYLSDELKFTHDRLYGADLLVTEGLLQELINYELMQSGLNLSHSQDKYFIKNLVDAASVILDRKYEAEWRRATELIQRGPDDLVDAFNKYLVVLARSQHDTYTSPFEIVQPNMALGLDIVTTESLFGYEPEQLSEYHRSKYLKPNAFTTESVVLPDTSGFLQHSARQRPVISFPKYNNYILDRRKFDQHTKVLVPLEMLGITPPESDEISQSGRRGSSHDHRAIVAYAQYKDVGQLLPDLYDETITRRWGVDVELATPILSLQILVPSMEREQETQRLEIPSRKIFSSSSPSSSSSSGSTEQQFVEVFDVPKAPTSSSEQQIEDIRITAHEIPPPVSSVEQQEASSDEDGEEREPHIRLNLDDIEFHGNSGEEVISPDSPEMLNPNYEGVSSTGSDEQPKGENEAVYRDRRLVKRQVEITYPSEQMQQTEQVVYRSLGSPHLAQPIKLQMWLDVDSARFGPRSNPQCVRWNSFTNQWTRLGCQTEIPDFDGDFNPAAQQAILVNCSCTHISSYAVIVDVIDPEDIPEPSLLVQITSYSAFLVSLPLLLGVLLALALLRGQQTNSNTIHQNIVLCVFCAELLFFVGMQSRRQLLESEFPCKLTAICLHYFWLAAFAWTTVDCVHLYRMLTEMRDINHGPMGFYFAMGYGAPAIVVGLSVGVRAHEYGNSLFCWLSVYEPVVWWLVGPIAGMSVVNLLILFVSVKAAFTLKDHVLGFGNLRTLLWLSVVSLPLMGVMWVLAVLAASEHSQLLSLLLSGVVLLHALFCLIGYCIINKRVRENLQRTCLRCMGRKVPLLDSSMVVSNSSHNVNAAARPSNFLASGYDTTTRRNIGISASSTTSRSTAKTSSSPYSDGQLRQTSTSTSNYNSASDAPSFLRGFESSTTGRSRGGEEKPSRRQRKDSDSGSETDGRSLELASSHSSDDDESRTARSSGTHRSTAVSSTPAYLPNITEHVQATTPPELNVVQSPQLFPSVNKPVYAPRWSSQLPDAYLQSPPNIGRWSQDTGSDNEHVHGQAKMTISPNPLPNPDLTDTSYLQQHHNKINMPPSILENIRDAREGYEDSLYGRRGEYPDKYGSYKPPSHYGSEKDYPGGGSGSQTIGHMRSFHPDAAYLSDNIYDKQRTLGSGYLGAKSESPYLSKDRITPDIYGSRDGHYSLKRQPAYATDSLHSVHSLLKNDYHQQQQQQQQHHLQDRLSEGSDKNGYHFPYTAEEDHLPARKLSHTQPPSLHGSQLMQPPGVGLVNDVNNPGLMGRHTLNGGSRHSSRASSPPSTMVAPMQPLGPLTSITDTERNIDDDETTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	N-linked_Glycosylation	PPGTVIFNASVYKLG CCCEEEEEEEEEECC	21.85	-
179	N-linked_Glycosylation	LEEVFRQNSTEFRAG HHHHHHHCCCCEECC	46.79	-
340	N-linked_Glycosylation	VYHHQEFNDTDIARR EEECCCCCHHHHHHH	50.98	-
671	N-linked_Glycosylation	GGSPSRSNTTQLLVN CCCCCCCCCCEEEEE	46.14	-
886	N-linked_Glycosylation	DTATVHINITDANNF CCEEEEEEECCCCCC	19.07	-
1269	N-linked_Glycosylation	NANLLRLNSSSGGLV CCCEEEEECCCCCEE	33.15	-
1374	N-linked_Glycosylation	DVSSRILNVSFSARR CCHHHHEEEEEECCC	25.64	-
1441	N-linked_Glycosylation	LTVLKFGNASEFIHS CHHHHHCCHHHHCCC	43.35	-
1650	N-linked_Glycosylation	QVEVVYLNRSVTLVL EEEEEEECCCEEEEE	19.25	-
1678	N-linked_Glycosylation	GDRWSCANRTTLKLD CCCCCCCCCCCCCCH	46.27	-
1747	N-linked_Glycosylation	LNSYVADNGTLAGCP CHHEECCCCCCCCCC	35.29	-
1843	N-linked_Glycosylation	LQIQIGQNSSAAVCL EEEEECCCCHHHHHH	32.49	-
1975	N-linked_Glycosylation	QCPDHCPNHSSCQSS CCCCCCCCCCCCCCC	53.73	-
2016	N-linked_Glycosylation	ASGVCRANTSLPRGY CCCCCCCCCCCCCCC	15.73	-
2028	N-linked_Glycosylation	RGYDCECNSSSRHGD CCCCCCCCCCCCCCC	23.72	-
2071	N-linked_Glycosylation	QGYHPDCNKTTGQCY CCCCCCCCCCCCCEE	52.68	-
2088	N-linked_Glycosylation	TNHYQPPNETACLSC CCCCCCCCCCEEEEC	66.97	-
2196	N-linked_Glycosylation	WNTPDMYNCTSEPFV CCCCCHHCCCCHHHH	18.89	-
2320	N-linked_Glycosylation	ELMQSGLNLSHSQDK HHHHCCCCCCCCCCH	42.92	-
2562	Phosphorylation	TQRLEIPSRKIFSSS HHCCCCCCCHHCCCC	52.44	22668510
2784	N-linked_Glycosylation	AQQAILVNCSCTHIS HHHHHHHCCCCCCCC	14.45	-
3199	Phosphorylation	LELASSHSSDDDESR EEEHHHCCCCCHHHC	37.09	22817900
3200	Phosphorylation	ELASSHSSDDDESRT EEHHHCCCCCHHHCH	39.37	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELF1_DROME	grh	genetic	14706698
INTU_DROME	in	genetic	11973308
DL_DROME	Dl	genetic	12015972
FRIZ_DROME	fz	genetic	15329345
FRIZ_DROME	fz	physical	18555784
ESN_DROME	esn	physical	21937715

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3199 AND SER-3200, ANDMASS SPECTROMETRY.
PubMed: 18327897