DCTN1_DROME - dbPTM
DCTN1_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DCTN1_DROME
UniProt AC P13496
Protein Name Dynactin subunit 1
Gene Name DCTN1-p150 {ECO:0000312|FlyBase:FBgn0001108}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1265
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton.
Protein Description Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles..
Protein Sequence MSEKNLKVGARVELTGKDLLGTVAYVGMTSFAVGKWVGVVLDEPKGKNSGSIKGQQYFQCDENCGMFVRPTQLRLLEAAPGSRRSIEDVSGATPTAAQPTKARLSSSRTSLSSSRQSLLGSRTQLTTSLSERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGNGAASHASSKRASFVETGFLEILKPQFTPSQPLRSPSFTMPSNSGAEDKVALLEAQKTSAELQAQLADLTEKLETLKQRRNEDKERLREFDKMKIQFEQLQEFRTKIMGAQASLQKELLRAKQEAKDAIEAKEQHAQEMADLADNVEMITLDKEMAEEKADTLQLELESSKERIEELEVDLELLRSEMQNKAESAIGNISGGGDSPGLSTYEFKQLEQQNIRLKETLVRLRDLSAHDKHDIQKLSKELEMKRSEVTELERTKEKLSAKIDELEAIVADLQEQVDAALGAEEMVEQLAEKKMELEDKVKLLEEEIAQLEALEEVHEQLVESNHELELDLREELDLANGAKKEVLRERDAAIETIYDRDQTIVKFRELVQKLNDQLTELRDRNSSNEKESLQDPSLKMVTETIDYKQMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPESFMSRGGDHDSILVILLISRIVFKCDIVVSQTRERFPPVDAITREAVTQGHAVQQYAFKCRLLHYVHSLQCALHQILYGLNSCQPDTLLRAGSSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLAGEQLLNEIQMIRDCVASLGAACESILSDTAIAKVIIQEAGATSDSVLLIQFLNENMESVRQQVKLIKRRLPSDQHVIKSGLSQHKVEAMRGLAQNISRIMSAMHQATKQSLAAIVSTIESDNAAEHTLPQEKYWALLTASCERIYEQDDRGPTQNFKTLLAQANSDLQLIAQHLLDKEYDIISAANNASNQQKSGAHSTPITQRAQLIKKQLEQKNVLAATLENREADVKQLKVAAKMKQNELSEMQIRKDLAEKKLSVLQNEYEHAVDKWKQKYEETSLQLQLKEKEFEETMDHLQSDIDALESEKSDLRDKLKLNSTTGKVQPGSESHSPHNISLSGNTSTAPGISNVSYSAPAGTAPVVAEEVELLKNAFNQERNQRLRLQAQDMRAKLSQFEPLHVPQPQDQRITALESELTRMKHAWVLSLLQVRSQDSVNSGTRIDAVALQRRNQPVPLKGEISSKASQLASDILTEYLQRKPHRATHGQFASFPTVDVKRVLQI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
85PhosphorylationAAPGSRRSIEDVSGA
HCCCCCCCHHHCCCC		29.2621082442
90PhosphorylationRRSIEDVSGATPTAA
CCCHHHCCCCCCCCC		34.7222668510
93PhosphorylationIEDVSGATPTAAQPT
HHHCCCCCCCCCCCC		25.3828490779
110PhosphorylationRLSSSRTSLSSSRQS
HCCCCCCCCHHHHHH		25.7422817900
112PhosphorylationSSSRTSLSSSRQSLL
CCCCCCCHHHHHHHH		26.4929892262
113PhosphorylationSSRTSLSSSRQSLLG
CCCCCCHHHHHHHHC		34.5327626673
114PhosphorylationSRTSLSSSRQSLLGS
CCCCCHHHHHHHHCC		30.8522817900
117PhosphorylationSLSSSRQSLLGSRTQ
CCHHHHHHHHCCCCE		25.1722817900
121PhosphorylationSRQSLLGSRTQLTTS
HHHHHHCCCCEECCC		31.9325749252
123PhosphorylationQSLLGSRTQLTTSLS
HHHHCCCCEECCCHH		29.6325749252
126PhosphorylationLGSRTQLTTSLSERT
HCCCCEECCCHHHHC		12.4329892262
127PhosphorylationGSRTQLTTSLSERTA
CCCCEECCCHHHHCC		35.9419429919
128PhosphorylationSRTQLTTSLSERTAS
CCCEECCCHHHHCCC		25.3519429919
133PhosphorylationTTSLSERTASSSSIG
CCCHHHHCCCCCCCC		27.1719429919
135PhosphorylationSLSERTASSSSIGPR
CHHHHCCCCCCCCCC		30.0919429919
136PhosphorylationLSERTASSSSIGPRK
HHHHCCCCCCCCCCC		26.1619429919
137PhosphorylationSERTASSSSIGPRKS
HHHCCCCCCCCCCCC		24.3919429919
138PhosphorylationERTASSSSIGPRKSL
HHCCCCCCCCCCCCC		33.2519429919
144PhosphorylationSSIGPRKSLAPQNSK
CCCCCCCCCCCCCCC		30.9219429919
150PhosphorylationKSLAPQNSKDKESPS
CCCCCCCCCCCCCCC		36.6627794539
183PhosphorylationHASSKRASFVETGFL
CCCCCCCCHHHCCHH		33.5819429919
187PhosphorylationKRASFVETGFLEILK
CCCCHHHCCHHHHHC		28.1219429919
198PhosphorylationEILKPQFTPSQPLRS
HHHCCCCCCCCCCCC		19.4519429919
200PhosphorylationLKPQFTPSQPLRSPS
HCCCCCCCCCCCCCC		41.1819429919
205PhosphorylationTPSQPLRSPSFTMPS
CCCCCCCCCCCCCCC		32.3619429919
207PhosphorylationSQPLRSPSFTMPSNS
CCCCCCCCCCCCCCC		34.3019429919
209PhosphorylationPLRSPSFTMPSNSGA
CCCCCCCCCCCCCCH		32.2919429919
212PhosphorylationSPSFTMPSNSGAEDK
CCCCCCCCCCCHHHH		32.5719429919
214PhosphorylationSFTMPSNSGAEDKVA
CCCCCCCCCHHHHHH		43.6619429919
370PhosphorylationESAIGNISGGGDSPG
HHHHCCCCCCCCCCC		35.0729892262
375PhosphorylationNISGGGDSPGLSTYE
CCCCCCCCCCCCHHH		24.9219429919
379PhosphorylationGGDSPGLSTYEFKQL
CCCCCCCCHHHHHHH		34.5522817900
568PhosphorylationNSSNEKESLQDPSLK
CCCCCCHHHCCCCHH		42.2627794539
573PhosphorylationKESLQDPSLKMVTET
CHHHCCCCHHHHHHH		49.2427794539
1091PhosphorylationTGKVQPGSESHSPHN
CCCCCCCCCCCCCCC		42.4821082442
1093PhosphorylationKVQPGSESHSPHNIS
CCCCCCCCCCCCCEE		30.8421082442
1095PhosphorylationQPGSESHSPHNISLS
CCCCCCCCCCCEEEC		36.8121082442
1117PhosphorylationGISNVSYSAPAGTAP
CCCEEEEECCCCCCC		21.9218327897
1247PhosphorylationQRKPHRATHGQFASF
HHCCCCCCCCCCCCC		26.8822817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DCTN1_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DCTN1_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DCTN1_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DCTN2_DROMEDmnphysical
22036573
ACTZ_DROMEArp1physical
22036573
7LESS_DROMEsevgenetic
18054857
SPTCB_DROMEbeta-Specgenetic
20368622
STAR_DROMESgenetic
18653542
SUH_DROMESu(H)genetic
19948010
SPITZ_DROMEspigenetic
18653542
LIS1_DROMELis-1genetic
10993674
KINH_DROMEKhcgenetic
22542187
KINH_DROMEKhcgenetic
15329347
DYHC_DROMEDhc64Cgenetic
7593168
DYHC_DROMEDhc64Cgenetic
6816671
DYHC_DROMEDhc64Cgenetic
18653542
SIRT2_DROMESirt2genetic
23596322
DYIN_DROMEswgenetic
12454067
DYIN_DROMEswgenetic
15329347
DYIN_DROMEswgenetic
11071907
APKC_DROMEaPKCgenetic
19948010
TBG1_DROMEgammaTub23Cphysical
22542187
TBB1_DROMEbetaTub56Dphysical
22542187
TBB3_DROMEbetaTub60Dphysical
22542187
HAIR_DROMEhphysical
23918939
TBA4_DROMEalphaTub67Cphysical
22542187
BCD_DROMEbcdphysical
24244700
TBA1_DROMEalphaTub84Bphysical
22542187
OSKA_DROMEoskphysical
24244700
DYIN_DROMEswphysical
21931160
DYIN_DROMEswphysical
22669947
K10_DROMEfs(1)K10physical
23918939
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DCTN1_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-110; SER-114;SER-117; SER-121; SER-183 AND SER-1117, AND MASS SPECTROMETRY.

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