SIRT2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIRT2_DROME
• UniProt AC: Q9I7I7
• Protein Name: NAD-dependent protein deacetylase Sirt2
• Gene Name: Sirt2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 355
• Protein Description: NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span..
• Protein Sequence: MDKVRRFFANTLHLGGSSDAKEEVKVEKVIPDLSFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCIRLLINRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALGWDQELQQLITSERKKLSGSQNSEELQQGKEKPQSDPDKMTSGDRDKKDASL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	NTLHLGGSSDAKEEV HHCCCCCCCCHHHHC	24.20	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIRT2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIRT2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIRT2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VTU3_DROME	Vm34Ca	physical	14605208
VTU2_DROME	Vm26Ab	physical	15575970
GUS_DROME	gus	physical	15575970
PGAM5_DROME	Pgam5	physical	15575970
PP12_DROME	Pp1-87B	physical	15575970
CEG1A_DROME	CenG1A	physical	15575970
DIMM_DROME	dimm	physical	15575970
MED15_DROME	MED15	physical	15575970

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.