| UniProt ID | DYIN_DROME | |
|---|---|---|
| UniProt AC | Q24246 | |
| Protein Name | Cytoplasmic dynein 1 intermediate chain | |
| Gene Name | sw | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 663 | |
| Subcellular Localization |
Cytoplasm, cytoskeleton . Isoform 2c: Lysosome membrane Peripheral membrane protein Cytoplasmic side. Aggregates in cytoplasm around lysosomes. Isoform 2a: Nucleus membrane Peripheral membrane protein Cytoplasmic side. Aggregates in cytopl |
|
| Protein Description | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).. | |
| Protein Sequence | MDRKAELERKKAKLAALREEKDRRRREKEIKDMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVAPVSEVLSSLSSVNSMTSDNSNTQTPDASLQATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSDEV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 287 | Phosphorylation | DYIGGGDSEEANDER CCCCCCCCHHHCCHH | 40.38 | 22668510 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DYIN_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DYIN_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DYIN_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DYL1_DROME | ctp | genetic | 15829565 | |
| DYL1_DROME | ctp | physical | 11914076 | |
| DYL1_DROME | ctp | physical | 17428790 | |
| DYL1_DROME | ctp | physical | 16949604 | |
| DYL1_DROME | ctp | physical | 17570393 | |
| DYL1_DROME | ctp | physical | 20472935 | |
| DYL1_DROME | ctp | physical | 15581372 | |
| GRK_DROME | grk | physical | 24244700 | |
| LIS1_DROME | Lis-1 | physical | 23918939 | |
| KINH_DROME | Khc | physical | 24244700 | |
| DYHC_DROME | Dhc64C | physical | 18799620 | |
| DYHC_DROME | Dhc64C | physical | 23918939 | |
| DYHC_DROME | Dhc64C | physical | 24244700 | |
| HAIR_DROME | h | physical | 23918939 | |
| NDE1_DROME | nudE | physical | 22669947 | |
| DCTN1_DROME | Gl | physical | 23918939 | |
| DCTN1_DROME | Gl | physical | 24244700 | |
| BCD_DROME | bcd | physical | 24244700 | |
| OSKA_DROME | osk | physical | 24244700 | |
| DYLT_DROME | Dlc90F | physical | 11914076 | |
| DYLT_DROME | Dlc90F | physical | 17428790 | |
| NANOS_DROME | nos | physical | 21376599 | |
| K10_DROME | fs(1)K10 | physical | 23918939 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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