DCTN2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCTN2_DROME
• UniProt AC: Q7K2D2
• Protein Name: Dynactin subunit 2
• Gene Name: DCTN2-p50 {ECO:0000312|FlyBase:FBgn0021825}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 380
• Subcellular Localization: Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.
• Protein Description: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity)..
• Protein Sequence: MADPKFQNLPGIAYDQPDVYETPDDPELDTSDYYEEEPENEAIERLHISPSVAHKRFSGATVEGSVDFTDRIGRRMCRGYDTRGSSDYELVGQGEKETPVQKCQRLQIEMNELLNEVAALQVDRKVADEEKQSYDAVATVISTARKVLESLKLEQVLGKEQTPGSKQVKALISQVEEFKQSGVLTAIPTPGTDLAATARVASLEQRISQLEKVLGAQPDKLSRLTAATNTTNVLEAVRHLSTKAALIQPDKLDTIEQRLTSLAGKMDAIAEKSSGSAQDAKRDQKITELYDIAKRTEPVVEILPHVIERMQALEALHKYANNFAKIIAEIEQKQGTITTSLVNNKELLHSVQETFAQNLETINSKVAKVEQRVAAISSAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	PDDPELDTSDYYEEE CCCCCCCCCCCCCCC	35.80	19429919
31	Phosphorylation	DDPELDTSDYYEEEP CCCCCCCCCCCCCCC	24.23	19429919
33	Phosphorylation	PELDTSDYYEEEPEN CCCCCCCCCCCCCCC	16.73	19429919
34	Phosphorylation	ELDTSDYYEEEPENE CCCCCCCCCCCCCCH	23.12	19429919
49	Phosphorylation	AIERLHISPSVAHKR HHHHHCCCHHHCCCC	10.60	19429919
51	Phosphorylation	ERLHISPSVAHKRFS HHHCCCHHHCCCCCC	25.75	21082442
58	Phosphorylation	SVAHKRFSGATVEGS HHCCCCCCCCEEEEC	31.39	22817900
61	Phosphorylation	HKRFSGATVEGSVDF CCCCCCCEEEECCCC	23.71	21082442
86	Phosphorylation	GYDTRGSSDYELVGQ CCCCCCCCCCEECCC	47.22	22817900
173	Phosphorylation	KQVKALISQVEEFKQ HHHHHHHHHHHHHHH	29.08	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCTN2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCTN2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCTN2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAPZA_DROME	cpa	physical	22036573
KINH_DROME	Khc	genetic	12477386
KLC_DROME	Klc	genetic	12477386
DCTN1_DROME	Gl	genetic	12477386
BICD_DROME	BicD	physical	23918939
LIS1_DROME	Lis-1	physical	23918939
DYHC_DROME	Dhc64C	physical	14711415
DYHC_DROME	Dhc64C	physical	23918939
HAIR_DROME	h	physical	23918939
DCTN1_DROME	Gl	physical	14711415
DYIN_DROME	sw	physical	23918939
K10_DROME	fs(1)K10	physical	23918939

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-58 AND SER-86,AND MASS SPECTROMETRY.
PubMed: 18327897