| UniProt ID | A4_DROME | |
|---|---|---|
| UniProt AC | P14599 | |
| Protein Name | Amyloid-beta-like protein | |
| Gene Name | Appl | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 887 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | During development, plays a role in the regulation of the neddylation pathway. Appl and APP-BP1 interact antagonistically during development.. | |
| Protein Sequence | MCAALRRNLLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTAQPTSDPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLSDTEYGEATVSSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQNVTTHHPIVREEKIVPNMQINGYENPTYKYFEVKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 150 | N-linked_Glycosylation | CLFDHIHNASRCWPF CCHHHHCCCCCCCCC | 38.72 | - | |
| 161 | N-linked_Glycosylation | CWPFVRWNQTGAAAC CCCCCCCCCCHHHHH | 20.97 | - | |
| 237 | N-linked_Glycosylation | MNDEDDSNDSNYSKD CCCCCCCCCCCCCCC | 64.82 | - | |
| 240 | N-linked_Glycosylation | EDDSNDSNYSKDANE CCCCCCCCCCCCCCC | 48.22 | - | |
| 339 | Phosphorylation | VSLKSDSSSPSSAPV EEEECCCCCCCCCCC | 51.78 | 27794539 | |
| 574 | N-linked_Glycosylation | IDIDRAVNQSMTMLK HHHHHHHHHHHHHHH | 27.50 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of A4_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of A4_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of A4_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| JIP1_DROME | Aplip1 | physical | 11912189 | |
| F10A1_DROME | HIP-R | physical | 22036573 | |
| F10A2_DROME | HIP-R | physical | 22036573 | |
| FAS2_DROME | Fas2 | genetic | 15976083 | |
| KINH_DROME | Khc | genetic | 10322116 | |
| ULA1_DROME | APP-BP1 | genetic | 16628230 | |
| SRA_DROME | sra | genetic | 24086147 | |
| A4_DROME | Appl | physical | 22266106 | |
| FAS2_DROME | Fas2 | physical | 15976083 | |
| ULA1_DROME | APP-BP1 | physical | 16628230 | |
| FRIZ_DROME | fz | physical | 23690751 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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