FAS2_DROME - dbPTM
FAS2_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FAS2_DROME
UniProt AC P34082
Protein Name Fasciclin-2
Gene Name Fas2
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 873
Subcellular Localization Isoform 1: Cell membrane
Single-pass type I membrane protein .
Isoform 2: Cell membrane
Lipid-anchor, GPI-anchor .
Protein Description Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles..
Protein Sequence MGELPPNSVGVFLALLLCSCSLIELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGVLLLLFVVDLLCCITVHMGVMATMCRKAKRSPSEIDDEAKLGSGQLVKEPPPSPLPLPPPVKLGGSPMSTPLDEKEPLRTPTGSIKQNSTIEFDGRFVHSRSGEIIGKNSAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
74N-linked_GlycosylationLQWKDNRNNTILPKP
EEECCCCCCCCCCCC		57.14-
250N-linked_GlycosylationEGKPFAANCTARGKP
CCCCCCCCCCCCCCC		21.90-
330N-linked_GlycosylationPQIYELYNVTGARTK
CHHHEEECCCCCCEE		37.1817893096
448N-linked_GlycosylationSWEQRKANLSCLAMG
CHHHHHHHHHHHHCC		35.21-
458N-linked_GlycosylationCLAMGIPNATIEWHW
HHHCCCCCCEEEEEE		48.04-
576N-linked_GlycosylationPDWSTAYNRSWSPDS
CCHHHCCCCCCCCCC		29.1017893096
804PhosphorylationDDEAKLGSGQLVKEP
CCCCCCCCCCCCCCC		33.5327794539
814PhosphorylationLVKEPPPSPLPLPPP
CCCCCCCCCCCCCCC		44.8627794539
827PhosphorylationPPVKLGGSPMSTPLD
CCEECCCCCCCCCCC		18.6822817900
841PhosphorylationDEKEPLRTPTGSIKQ
CCCCCCCCCCCCCCC		32.6522817900
845PhosphorylationPLRTPTGSIKQNSTI
CCCCCCCCCCCCCEE		29.1422817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FAS2_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FAS2_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FAS2_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BAF_DROMEbafphysical
22036573
PHS_DROMEPcdphysical
22036573
RS27A_DROMERpS27Aphysical
24292889
VPS72_DROMEYL-1physical
21447707
CPR1_DROMECG12163physical
21447707
KP58_DROMEPitslrephysical
21447707
INTU_DROMEinphysical
21447707
HERC2_DROMEHERC2physical
21447707
R10AB_DROMERpL10Abphysical
21447707
RS10B_DROMERpS10bphysical
21447707
KPC4_DROMEPkcdeltaphysical
21447707
OSM1_DROMEOseg2physical
21447707
ZER1_DROMECG12084physical
21447707
NU301_DROMEE(bx)physical
21447707
RTF1_DROMERtf1physical
21447707
RL17_DROMERpL17physical
21447707
VA0D1_DROMEVhaAC39-1physical
21447707
PKN_DROMEPknphysical
21447707
LIN54_DROMEmip120physical
21447707
KLD10_DROMEslimphysical
21447707
TBB1_DROMEbetaTub56Dphysical
21447707
ATPG_DROMEATPsyn-gammaphysical
21447707
RL3_DROMERpL3physical
21447707
HIRA_DROMEHiraphysical
21447707
PRS8_DROMERpt6physical
21447707
GBLP_DROMERack1physical
21447707
AUB_DROMEaubphysical
21447707
C3G_DROMEC3Gphysical
21447707
MYSA_DROMEMhcphysical
21447707
TBA1_DROMEalphaTub84Bphysical
21447707
TPM1_DROMETm1physical
21447707
TPM4_DROMETm1physical
21447707
G3P2_DROMEGapdh2physical
21447707
LAM0_DROMELamphysical
21447707
RL4_DROMERpL4physical
21447707
ACT1_DROMEAct5Cphysical
21447707
HSP7B_DROMEHsc70-2physical
21447707
EF2_DROMEEF2physical
21447707
PCNA_DROMEPCNAphysical
21447707
DEC11_DROMEdec-1physical
21447707
DEC12_DROMEdec-1physical
21447707
DEC13_DROMEdec-1physical
21447707
PCX_DROMEpcxphysical
21447707
ATC1_DROMECa-P60Aphysical
21447707
DPOLA_DROMEDNApol-alpha180physical
21447707
INX1_DROMEogrephysical
21447707
XPA_DROMEXpacphysical
21447707
1433Z_DROME14-3-3zetaphysical
21447707
BNB_DROMEbnbphysical
21447707
HSP7C_DROMEHsc70-3physical
21447707
RL7_DROMERpL7physical
21447707
SCNA_DROMEparaphysical
21447707
PSC_DROMEPscphysical
21447707
RSSA_DROMEstaphysical
21447707
BNK_DROMEbnkphysical
21447707
RS4_DROMERpS4physical
21447707
SCRT_DROMEstphysical
21447707
RL7A_DROMERpL7Aphysical
21447707
KL61_DROMEKlp61Fphysical
21447707
TCPG_DROMECctgammaphysical
21447707
SRP_DROMEsrpphysical
21447707
ACT3_DROMEAct57Bphysical
21447707
DPOD1_DROMEDNApol-deltaphysical
21447707
FKB39_DROMEFK506-bp1physical
21447707
PDI_DROMEPdiphysical
21447707
CNN_DROMEcnnphysical
21447707
SIF2_DROMEsifphysical
21447707
SIF1_DROMEsifphysical
21447707
DAB_DROMEDabphysical
21447707
YL_DROMEylphysical
21447707
SPTCB_DROMEbeta-Specphysical
21447707
MYS9_DROMEjarphysical
21447707
SSRP1_DROMESsrpphysical
21447707
RS3_DROMERpS3physical
21447707
KU70_DROMEIrbpphysical
21447707
FLII_DROMEfliIphysical
21447707
RYR_DROMERyRphysical
21447707
ADT_DROMEsesBphysical
21447707
VATA2_DROMEVha68-2physical
21447707
DPOG1_DROMEtamphysical
21447707
ARMI_DROMEarmiphysical
21447707
RRP8_DROMECG7137physical
21447707
TERA_DROMETER94physical
21447707
PRP39_DROMECG1646physical
21447707
Y7065_DROMECG7065physical
21447707
MICAL_DROMEMicalphysical
21447707
TRA1_DROMENipped-Aphysical
21447707
SPT2_DROMECG5815physical
21447707
LVA_DROMElvaphysical
21447707
GOGA5_DROMEGolgin84physical
21447707
NACA_DROMENacalphaphysical
21447707
VDAC_DROMEporinphysical
21447707
NEMO_DROMEkeyphysical
21447707
TITIN_DROMEslsphysical
21447707
EF1G_DROMEEf1gammaphysical
21447707
SWS_DROMEswsphysical
21447707
PSMD6_DROMERpn7physical
21447707
PRDX1_DROMEJafrac1physical
21447707
APLP_DROMERfabgphysical
21447707
SIN1_DROMESin1physical
21447707
41_DROMEcoraphysical
21447707
UNC80_DROMEunc80physical
21447707
DMDD_DROMEDysphysical
21447707
DMDE_DROMEDysphysical
21447707
DMDB_DROMEDysphysical
21447707
DMDA_DROMEDysphysical
21447707
TIM16_DROMEblpphysical
21447707
ZFY26_DROMECG5270physical
21447707
A4_DROMEApplgenetic
15976083
SEM2A_DROMESema-2agenetic
9604933
GNAS_DROMEGalphasgenetic
15063169
GIL_DROMEaosgenetic
19141676
TIMP_DROMETimpgenetic
18045838
SIF2_DROMEsifgenetic
10976048
SIF1_DROMEsifgenetic
10976048
JNK_DROMEbskgenetic
26586184
ITBX_DROMEmysgenetic
12091308
ERKA_DROMErlgenetic
11923414
FAS2_DROMEFas2physical
23827685
DLG1_DROMEdlg1physical
9390515
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FAS2_DROME

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-330 AND ASN-576, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-827; THR-841 ANDSER-845, AND MASS SPECTROMETRY.

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