TITIN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TITIN_DROME
• UniProt AC: Q9I7U4
• Protein Name: Titin
• Gene Name: sls
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 18141
• Subcellular Localization: Cytoplasm . Nucleus . Chromosome . Uniformly distributed along condensed mitotic chromosomes (PubMed:9548712).; Isoform A: Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with ball and mask in Z-lines of indirect flight muscle (PubMed:2625
• Protein Description: Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase..
• Protein Sequence: MQRQNPNPYQQQNQQHQQVQQFSSQEYSHSSQEQHQEQRISRTEQHVQRSQVTTQRQVQQHHGGSIGGAYVPPSLTHVYAQGDISPPVFEQIFKNARFAQGGNALFEGRLRGNPKPFVTWTRKGAPLLESQKFRMSYNEATGDVSLLINQIGPGDEGEYTCTARNQYGEAICSVYIQPEGAPMPALQPIQNLEKNIYSNGYSYTSIEEEFRVDTFEYRLLREVSFREAITRRSGYEQDSQLSQELDRNQGPAQAPQISQKPRSSKLIEGSDAVFTARVGSNPKPRLTWFHNGQRLVASQKYEISYSSGVATLRVKNATARDGGHYTLLAENLQGCVVSSAVLAVEPAAETAYEPKPVDVMAEQLEAGKALPPAFVKAFGDREITEGRMTRFDCRVTGNPYPEVFWLINGRQVRDDASHKILVNESGSHSLMITNVTRLDAGAVQCLARNKAGEVAIEAQLNVLEKEQVVAPQFVQRFSTMTVREGEPITMSANAIGTPQPRITWQKDGVQISSTAERFVGIDGGATCLEIPRVTANDAGWYQCTAQNIAGSTANRARLYVEVPREQPNYEQRRLNLPRPTKVIEPEPIPGPEIIYLRHVERAKPHLRPGEEDRVYPPPQFIIPLQNVQQTEGGRVHMEARIEPVGDPTMVVEWYLNGRPLAASARATSVFKFGFIALDLLSIMGHDSGEYMCRVTNASGVAESRAILSVVQRPSIEQSSQNPNSLQYINQLEDYSRYQRTESIDEQLNQAPQFIRPLRDLGEFEEGKNVHFEAQVTPVNDPSMRVEWYKDGLPITASSRITAIFNFGYVSLNILHLRAEDAGTYTVRAVNRIGEAISQSSIRVHSRSQVTADLGIPEQQRYIEKVEELEDYRKSQQRRHVQEAAEAIAPPQFKTPIQNQLDLREHAHAHFEARLEPVGDSTMRVEWLKDGQPLEASSRITTYHNFGYVALTIKQLTIYDAGTYTCRAYNAMGQDTTVAQLTVISKNEIVSESQHPGGLQKIQHLEDSSRYGRREEEETYITQAPRFLGPLKGTTKILEGQRAHFEARVEPQSDLGLVIEWYHNGRSITAANRIQTYYDFGYVALDISQVRAEDAGVYLVVARNKLGEAQQQATMIVETRSSIDTSSMHRGLYEKTQNLENKPFVEPQYDIEEISKSKPVFVTPLSDPKPIHDGKNIHLECRLEPMGDPTMRVEWFHNGRPVTVGSRFRTYYDFGFVALDIIKATAADSGEYTVRATNHLGTAHTSACVRVIDHTDVVTETQNEQSLEQIQLLEDSRRRHHQEEDITIMQAPQFTRGLHNIETIEGTNVHLECRLQPVGDPSMRIEWFVNGKPVKTGHRFRPAYEFDYVALDLLGCYAIDSGVYTCQARNQLGEAVTSCSVRIIAKNDLILETQNESGLQKIQYLEDSTRHRRSEFVDEVVNIRPRFLTHPKSLTNTREGGHAHFECKIEPVTDPNLKVEWFKNGRPITVGHRFRPIHDFGYVALDIVHLIAEDSGVYTCRAVNLIGSDETQVELQCRSGEQIVTVTQNEAGLEQIHYLEDRSRYTRREEIDESTKQAPVFTTSLKNVEIKENQRAHFECRLIPVSDPSMRVEWYHNNLPLKSGSRFTETNNFGFVALDIMSTLPEDAGTYTCRAYNAVGEAITSAVAVVHTKKSIYLESQHETALPRLQHLEDGSKRQRISVQDEFVSQAPVFTMPVRDVRVAENQAVHFEARLIPVGDPKLTVEWLRNGQPIEASNRTTTMHDFGYVALNMKYVNPEDSGTYTCRAVNELGQAVTSASLIVQSKTSIQLETQHEAAMHKIHQLEDHSRYQRREEEEYTVTTAPVFVTKLIGPSNLVEGQSAHYECRIEPYPDPNLKVEWFHNGKPLSTGHRFRTTYDFGFAALDILTVYAEDSGEYTCRVTNNLGEAINSIVLNVTSRSSIIHETQHEEALTKIQHLEDTSRFQRKTDEEQFHAERPQFGRPLRNAKVNEGAPVHLEATLIPVNDPTMKVEWYCNGRPIQTGHRFKTTYDFGFVALDILYAHAEDTGTYMCKAKNAIGEAVTTCAVNVTANKTLDLDTLDAQRLEKIRQLETYAPPPKPVVEEKGQKPIFLTPLSNLEHLKEGEHAHLECRVEPINDPNLKIEWFCNGKQLPTGHRYRTTHDFGYVALDILYVYGEDTGTYICKATNQLGEAVNTCNVRVLNRRSMILDTQHPDALEKIQKLESKVPNARTEVGDAPISPPHFTAELRGSTEIYEGQTAHFEAQVAPVHDPNLRIEFYHNGKPLPSASRFHITFDFGYVSLDITHAVAEDAGEYSVRAVNALGQAVSSTNLRVIPRGTIISDTQHPEGLEKIRKLESTAPHQRQEPETPGTRQRPVFTQPLQNIDRINEHQTAHFEARLIPVGDPNLKVEWYRNEKIIEDSSRITKQHDFGFVSLDISHIRKEDEGVYMCRAVNPLGEAVTTASMRVVSEASIQMDTQHPDSISRIHQLEKPLAPRPTEPERLFEKPIFTQLLTGPSELWEGTHAHFEARVVPVGDPSLKFEWFINGVELQMGSRLRTTHDFGFVTLDITAVVPEDAGVYMCRAYNAAGEAVSSTAMKVKTKSNIDGQPLIPESWEAIRLKEAAMNRVPEMFVDSTPQQAPVFTTHLQSYDKLHEGQHVLLEAQVEPRADPNLRIEWFKNGISLTTGSRIRSTFDFGLVTLSINGLRADDSAIYTCKATNQVGEAVSTSSLKIEDRHWLQAESLHPDSLPRIGELEAPKEGRPEAPEPTYETPVFITHLNNIECKESDNVRFECNVEPARDPTMSIEWFYNGQPLQAAAKFKSIYDFGYCALDLTNSYAENSGVYTCKATNSKGSATTSGTLKCTGGKTMFLDTQHPQGEAGLEAVQETEEELANRYTSKTTKPETQYPPPVWTKPLQAEFHLSEAQPIHLEANVEPKEDPNLFIEWYFNGKMLNHGSRFKMTSEFGFVTMDMIEVYARDQGIYTCKAYNKAGEAFTSTTIFCSSKENIIESTQHPKGAEGLEQIQDLEDSLRKDGSKPEQPDLGIPPRFTTEFVNIADIGEGELAHFEANLIPVGDQSMVIEWFYNGKVLEASHRVRTIYAFGTVALEVLGTKIEDTGTYTCRATNKHGTAEISCNLECVDKPRGQKPRFTSHIQPLEGLKDGQSAHFECTLIPVNDPDLKVEWYHNGKLMRHSNRIKTVSDFGYVVLDISYLQDHDSGEYVCRAWNKYGEDFTRTTLNCGGRGGVFYDSLQPDSLQRIRELECPQGQQADTSAPLVAEPPKFITQIVDVTKLVEGQSAHFEARLTPITDPDLVVEWYFNGKKLPHGHRFRTFHDFGIVILDILYCYEENSGVYEARARNKYGEDVTRASLKCASKSSLILDSQLPRGMEGGLEKIANLEYSMVRTREETTEETKGKAPVFTVPLENIENLREGENAHFEARITPADDPKLKVEWYWNGRPLKAGSRFRTFCDFGFVILEISPVYPEDSGEYSCRAINEYGEAVTTATMKIQGKRSIIMESQLPKGMEGTIDRIAELEGLGSRSTEFVPDDDTGKPPEFITSPFDMVIGENALAHFECRLQPINDPSMRVDWFHNGKALWAGSRIKTINDFGFVILEIAGCYQRDSGLYTCKATNKHGEATVSCKLQVKGRQGIVMEPQLPSNFRTGTESLQKLEETMHKREELVTEDEQPNPPKFTEEIKDNLDVPEGGPIHFDCRVEPVGDPTMRIEWFYNGHVMATGSRVHQLNDFGFIALDVDYIYARDSGEYTCRATNKWGTATTSAKVTCKGKHNIVYESQLPEGMTSEKLKELERGRIPEAPKVVEEVFGPPKFTTQITSVTVDEAEAVRFECQVEPKTDPSLRVEWYRNGKPLPSGHRYRNIFDMGFVSLDILYVYGEDSGEYVCRAINNYGEDRTRATVSCKKLPTILLQNQVPRGMKRSDALTQMEATIKKYTSEVHLTEDDLFDPDRKQPPRFVTQIKEQLTLTEMAVTKFECQLAPVGDPNMKVEWFFNGKPLLHKNRFQPIYDFGYVAMNFGWVYPEDSGEYVCRATNLYGKDETRAIIKVSGKPGIVYDSQLPAHMQSIDRIREMEASWQVVPDEVDPDAKPRTKPVFVSKLEPQTVEEGDPARFCVRVTGHPRPRVMWLINGHTVVHGSRYKLTNDGMFHLDVPKTRQYDTGKVEVIARNSVGESIATTELKVVARSDDYRNVLKNSPRPWYDYELAAYQKERQENELEKVFDERKQVLSEQSSHTLKGVEHLKPKQYKPPTPDWQQNVKAKKSEDYYNKLQTLETEQLLKETNLRRDTHQYAIPGEKVVSSSQAKGMAQSYEENLQEKTSTTEVQAAPPKGIAQPSESSVHGREVHMNKQQQVQKEIQGDLEITRKITATETTEVEHKGTIQERVVQGPVKPAKAPVFTKKIQPCRVFENEQAKFEVEFEGEPNPTVKWYRESFPIQNSPDLQIHTFSGKSILIIRQVFVEDSAVFSCVAENRGGTAKCSANLVVEERRRAGKGGIQPPSFVTTIQSTTVATGQLARFDAKVTGTRPLDVYWLKNGMKIQPSIKFKMLEEDSVHTLLIIEPFAEDSGRYECVAVNAAGEARCDGDCIVQSPSKPEKPTTPGSEKAPHIVEQLKSQTVEEGSKVIFRCRVDGKPTPTARWMRGENFVKPSRYFQMSRQGEYYQLVISEAFPEDEGTYKCVAENKLGSIQTSAQLKVRPIENLDAPPTITALKDVSVTEGMPAQFKTTVTGKVKATSVQWFREGQLIPETPDFQMIFDGNSAVLLIGTTYEEDSGIFTVRVTSSTGQVESSAKLTVKKRRISAFQLRTIDSAEDESSSSGREDSAPESPHAFQPGQQPGQQFGQFLGVNGQGQHQGRSRQKKPKVRSKSLQPATKVIPWRKSSRPTRGRSLDKGVFLPGFKPEPVKSWTEETINLKATPIEKKKPAPKLEAAKVVLKSIKTERDQGIMSLGATLEQIIAGKTEKEAIPWITMREKLKAVESVQQQLNKFDLDEVYLQPLEGQIETEGQLPQQAQVEQVQRTKEIQRLKSMESVEIMEMTDQIDKLITQQQNAKDLIPWKEMRQQLKSVQRVTKQIDKFKIEEVELRHLQAQQAITEEYQTGTAEETVVMIDESSKGSISKVLRRDEQLQYEDQSNIYKQKFITTEDVNIMHVSEREKLEAQRLIREQQAVNWRQQQQRPQLQPLTSVEDTVISQTSERQKLVQQQSFIEEAQRQQFVQVEDSQMMSLEEYEHQKIINQRTQQEAFSWRQPREPQKFIQVEDSTLLHLQERHDTQEQQLLQQQPVMWDRGRKKPDQPQYVQPQEQRVKEEFVEKPKTYEEMHDELVEPTPIEQPQPVPVMWERGKKKPQPQEKTFEEAHDELVEPTPVQQPEPVPVMWERGKKKVAQQETVLSQEVVQTSQVVEQQIVEETKKTAVRRVIPPREPEQKVEQVTLKPTPRPRPKEAVKAEEIQLKPLRSTRPVPQPVEAEQKAYEEATDELTEEPIPQPQPVMWERGKKKPQKPQEEVTEIPKTLEIAVDTLEEEVPKPTEPQPQPVLWARGQKKPQKPDEQKQELPKSLEIAVDTIEEDLIKPVQPEPQPVLWERKKKKPQPQDVIEEKLDVAPTKTYEKAVDVLPDEPKVEEKPEPVLWQRGKKKIPKSEPTEEVHPDEVDAQIETVVKEDEMIVEEKRRIKKTKRPKSTKEVTEELFEEQPEEEISPEEEVPQKEVIEEIEEIVEEKRRLKKTKKPKLTQQVTEEETPHEEIIKESEEVVQEQEEIVEEKKKVKKVKKPKTVAEKQLKEEEIPTEETVEEEETAEDQQLVVEESKKVKKVKKPTGTVEKTDVEELPGEEVPVEEVPVEEVPEDVAPEEELIEEQEEIVDQDEIQEQKRKVKKAKKPKKTIEKTEIEIEEDQPEEEVLQEEIIGEQEEITERQRKVKSIKKPKKVVTEKTVDQTEQPEKPEESQAEEVKETVTEEPKKPKPAPEEAKVEQVEKISLKPAPRKQRLLPEKEQVEEVLLKPVKKIVAVSEAEQPETPETEFEVKEFAITTTEDILDVTKKRVKKKKPKTKVAAEESTEEPAEETEEFEEEATQPEEVQPVEEIPEEPQVKEVADERKTAPKPKPRKEEIIEKVEEVALKRVTRPKKELPQEATIEEVRLKPTQRTSIKPEEVKLEEVDLQHVEKKEDEIVQEEKRKTRKVKKPKHEDLPEIPDAEPTQLEEAEHIELEKQPKPEEDQPQVPWKRGEKKQPVEEVLEEKKWPSGKRRPLPEQQPEEVQLKPIPSKPIEEQQKPEKAIPGPQLVPEEKPESEEEELELEPLKLPEDKKPKEPKAKKEKKKKPKLKKATPSVDEVSEEVAEPFDEPIAEEDEVEEMPVDDVKVVAVSEDVLPEEEVVPTEETPEAKQKAHKKRTKRLKEASVEGQPQLLEAAIAEIEKVDEISQEISQKTITLLKKTEDTRPQFITTEQLIELDVEDVRRDLEMKVTSNIIKKEKRRVVLDDSQPLPELELITQKRIQEGIDKVADEELIEDQQLIQNQQETTTSEVIGQERKLVKKKKKEIKPPRITEKLRPRQCVPEEPTVLECKVEGVPFPEIKWYFNDILLFASEKYEITVMEQVAKLKIAKVTPSDVGVYTCEAKNEAGVATSRTNIILEKEQGVPPQFTKPLKIEFIEEKQPERLKVTVTCQVTGKPNPEVKWYRGIEEVIPSETVQMFYDEKTGDVALEVINPTPNEAVVYSVQAQNQFGRAIGNANILSRVDEVPREILKAPTVTPLSAVVVPTGGTLFFEAKYDGLPRPEVKWMRNGREIIENEETIIETTETTTTIKVVNMTRKRTGKYEVWAKNKVGEAKSSGSVVVSDQKPDEQIKPPRFIQPLEPKYFGEHEVAIIEAIVESEPLSSFQWFVHNEPIKSSNEVRIVSQANKSTLLIENFQSKFVGPFTCRAENVGGSVTSTATVNLIPQEEAEEFESPRFVEELVQPVEVMDGEALLLTCQVTGKPTPKVEWYHNAEKITENKETTISQDLQGVCQLQITEVFPENEGQYECVATNKIGKSVSKTNVKIQAFEYIPDSEITGLTGSEEDLLDRTLSIDEQAPKIIKKLPEKIEPKEGEQAKLEVKVVGKPKPKVKWLRDDEQIFASEEYQIENFEDGTSVLVINHVYPDDLGTISFEAYNPLGVAVTTALFAVEGIVGSKDYRKPEWVSQMEEMQVALKAAKCSPSLLNEMRDCRAALGETAKFSIQFAGNPIPDIQWYFNNVQLRASEKYRMVVQEQEATLEIMKITSEDCGYYNCKLINEIGMTMTRAKFDISSTSTIVEETKAKTTVKKKSGKKTMVKRSGASESQNVQKTEIRIIPTSAVETSMNVIKVKQPVSVLVEKSEISEVLVVKDREVADAEERSSQLIEEIEEEEEIEEKVQHDEEDEVEVQVEQKETYTSSKKIEITKTVELIRTKISEKIITIEDVQVLSHHEEVQWLLESIEAESFGQIGESALRDLATIGLLLRYGCEHYEITYMYEQNIFISLKKPESQSALVQLVEREGHEELISQILSESSNEDETILAATVGFKAFIRMIQTYEITIEIVIRKFVREDFISQDWKICGKERIVETSQIIESHEAITHVKIETATTKVEKLFKKQEQEHVQNLEQQEQVKIQVQTKQIAQMNTKIKKHKKHKQQEQEVSETTIQCEQKETLAHETSAELPQSETLEQIEESLSTYETLPIQNLSKDTLQTVAVSVTTELSTPSPTASRVQEEILPQKVLAINEEVLPLDEFGLRKESPRPKENKLTENIEVRLKHALNVSHAKTAESSKELPSKIPKSVKAQRKMKESRSLVVEAPNAEEAIEDLKPLKAVSQEVQSDILFSHEITEEQHQALETIEKLKPTSAIEDTVQQKLLSQEELIIAEVLPSETVGRDVTDVRPPGETISPRLTPNMSLCITECQPEDSIGEMQQAAKERMETPSMSVTESKAVGGQELEVLENVDHMPLITQPTKGLADYTIKAEEVPVQVQEIITFDSLERETVAKTQTAKSNALELFELSEGLVSSTADSHSPIAEDLPIFEKDVKEATIDMQMQHHVTTSETVSNENAVKDLKAVDTPKMAEGTLGQSSALTIGETQQMNLVETTVELIEPNVESTKPAKGALTEAYGTAESNEETLLESLGLVPDDNRKIEQGKVNISEGEYVAKVQTTTVTDTEGEFVSVAPKLVNPKFDFVEQSALQIKQDTTVEKEEILSSNIELAPQLATSNMFPAELKVTSIYEVQPGLTSSDIITEQTKSVSANQVFETMSIGVTSKPDMLESTSHIDAFQHPEFKTGDTILDENQQPLEVTNVQITESSTDIIDVLPNQKLTKAETVTDGFKYAEGLVVLPMESTIDKTEDTKPTAVNADISMHQQFGTDVREQEPLESTLTRTEDLKPQTQTTESQFGLLQSLETSSCVTLEGESVLSVKERHPEQSAAIGTSSALQVANITRPQHMESLDRLDEQKVPYYQANVNIGEITLPNVEKIDSFDVLSDLNTPDYNKSSKGRVQLIESTTSLKTTTAVVSESTEELKDLNITQPVHIKPKPYESDQKISISEQTNVLEHVSSLNPVLPALETIQSSIKSLHEINVRETDILEKEESLKDVDHISGRLAKIILDCTTGIAQVRQEETLEHEEDLKAPLIPLEKAIPASSELHRLPLTEYVQEQQGTSDMTDFKVSNKCASPNIDHLYETKSSEMIVYDSSINSVDSEFPAGIVPQKSLVPFRHTMVTENVAFNASENFEILSADQQIATNVQDSLSQSIIAEDQIAFETEQNLGLETTPTHKPKLLKDDQNLHAKLVDEATVYEAMGQEQKVDKYNIQQAEITHDLPQVYATDLQQTFEAEKEITTREQSYVAATTDIIPSRLGLAMTTKTHPVEGIDVLLSSPPKPSLAQTNYEETQHEVRVRETQAIEESEELTDGRLLPVSAVESIDSTFKVTSDSQQPPVFDKELSIPTVSPLEARAKPSLNLLQGTTTFDVIPLESSVLLKDTHVAVQKAQQEYVAQVESNKVHVQMDNLVMHKEDIFENAEIENFCKPITEGTQLETVVIEVVPIDNVGGIHLAPQPSTLLATLTSTDIVNQSHVIDTQVPLEMESEAQAPLDNIAQARIKSAEDHVHTNVSEVNVYEQTKAIQDQNKHGLFVKVSKNSDTSKAYLTTIQSTFLKEDILPKPNILQDTAQAAADELQSLVTEEVVSVSSIQETYELKIPLQKTANLTQQTPQNSVNVCQQLAYEETPDIAFEPHALTRATTSSVPTFLKPAENATVNIYENIEGHGDFKPGTVNLTSNSNLNSELVVSVVQEVTSVPSLGSLATVEPQELKAMPVTKSSTNLAYSEEVKGNKQEFTKIETVEEDDKQPETTVTVEELPYEEEKPEEIQELPEEVCVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRFIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETAEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEENDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPKTTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDNQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDMQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEVEKPDEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKPEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTKIETVEEDDKQPETTVTVEEVPYEEEKLEEIQELPEEVRVVETVTEDGKPKKKKIRTRVIKKVKGDKQEVTTIETVEEDDKKAETTVTVEETELSAPSVGKVQLKKRVIVQKPEDAVTVFELPERKSVILSEKEDGTPTKTVIKTRIIKKIQGPNMEVTKVQTVEEYEKAPQTIVSVEKFNTPFPELPEERLSEVVMLPDEVFESEAVDEEGRLKMIKTKKRIIRKPALDNTEEVTEIGIIEQDNVEPIYSVKIQERPLTESKPEDSKLIELPEHVTELNVILPDGKKKRRTVKSRAFKKSLDDDLDEVTTIHIIEEEDKEPLTKVNIEVVPSDEISITPIPIEELPEETVFTEELDENKKPKKKTTKTRTFKKRGPDDDEYFQIQTIDEEGKEPISLIRVVSDENIADIIDISKLDDEKVLKHKQKPHKHKDQYYKEYTITEPEEASADALQKPTKDKTPKQKKTLETPIEEVDETVIIDEGTGEQTDQIAIKRKPRKVQGNVQVEAVDEKPIEKKEKAKKKKVVKTKRDEMDDYIQFLIHQEIPKTVLQPYQRTEMELPQRARRDSSFKQPVKLTPMKIEKVEFKKPKMVEISSVVEFPQMLKLKAPKQRPQEEKKKKNEASFKNKKLKSWIRFVPYAPYCFPYVVTELETNREVGELSRNVDEAEEVLKLRPKKFKHSKPEKAELEEADLGAYESDHSDKSNKELLHPKYKRGKKEKIETPDESRKLKFGKGKVPQNEEASEEVNLKPVKLDIAEIEDAEMPVRTQEEEVVKKKKPKKSSKPEEGLQFEPIEFEEMERTSDIREESDTSVSVDTSTQEKPIYKKKKKVTPSPQKNQYKILPGQPREFEETPEDDLNLRKRQGERPDDDKADTKLKPFYKFEVLDLEPEGVQAETVPLSETIAKEPKKKRKIKVKTEQEDNTIEIVPLSPEDNDEQIFEITVTSSEIPQGDAKAKTIGKKKVKRMNKQELDDFVTELQEEPNQEVYETRMSDFYEVKLTELPSEMDSDKPTKRILRHEKGDEVQVLEIVESVVAPGEEPFYEINVISSANTEGDSEEITTDKIKKKSRKIKKDDLDAYIQQLINAEIPVTELEKYEKIDVDGKAKKPKKLKAKTKKPIIDEGETLQVGVTEHEPTKKLKTKKPEEKKNVIEKELAEHEAVPEYDEFLINKTESERPQEKRVEETEKDIVPIVDKVLADLNDCLPFVVVEEDLKDMPLATDVIALEDEKIIRKRKVRAKKDSKQYEIEIIETEKPGDIPDEARVIVITTEVSGDTIDGPAPSTTEAPKKSVRKVKKEKLKEFIVNIVEEAPLDHVSEIYEDVLRTPFRESSEKEDIPSFTTTVVEDEIVNPVLPEKIKTVDDVRVPKDKKKKIDNQKKIKISEFEPTPTSEDSTIEEYTPKLSEHDEDLQTDEYSVDVKDSLPKSKKKSTKKQKKESLPGPISLYTIRIEETTPEPITEKIYEDGKEVVRVINKRRIKKKAGPKEYLIEVIETYEDNNPEADVVIRTIETTPSIDSKPQEDHKIQVVQEKKPKTESLDNYIQKLIDQEIPQVDHKEFKATVLETSPESKKAKKIKKHHKKTTEVIDGIPITVIEVTIQETETDDEDFKPDEVTLKEIDHENAEEAPKVLKSKVSEEKPKSKKEKSLEFKIAEEDKPKPVLEDISEDVQVVQIIEEDGTPKQVEIKKKKVSRKHGPKEQVFEITETKAIDEPLSEVTVVEITDEQPQEEVLPAQEKKPIKKQKKLKPEDVNTYVVKVLEELTEPTQFETIPEDADDKPQPVIEDISENVQVVQIIEEDGTPKQVEIKKKKVSPKHGPKEQVFEITETRPSDEPLAEVTIVELTEEGLNKDIVIPQEKKTVKKPKKLKPEDIQSYVIRVLEEFNEPQWPASTEKPIIEDIAESIEIVPVTEEDGITKEVEVKKKKVSRKQGTKNQVFEIIETKTSDEPLAEVTILELSGDKSQEVTILPKEKKPIKKTIKLKPEDVESYVVNVLEEFCEPQSFESPEPTEGEAHETKTKTKKPKKPIVKAPENVILIEEMAPETVIENIVNEIGEEVKQVKTTKKLKKKEGPKEYLIEIKETYEENKPEGDIEITTTELVPEGSPDASDDQPVIVVQKIKKKKPVKDDLDKYIQQLIEQEITKTPLEEYEPTEMDSKKKPKKKVKSHNKKTIEVIDGLPVTIHEFNVEDIVSEPEDMETPKTLLDEIKEIPQLPDDSSKYLVNISDEFGEADKPIKQPTQDQPIKKEKPLKKKKDVEYPVSLEAFDHTVKVVSEPTLEGTVKEVTVKKRKVSRRKGSKDHIFEITETTSEDRPTAEVTVVELSSDEVLDSEEKPKHERKIVKKPKQLKKDDVEEYIINIIEEFIQPIPVGLVEDEVEKVQKEETKKPKKSPITYIATEQEDNDNNYDALVKEDLDQPIERALEKPSSPLEYTISVEEDSVGEEQKQPKPKKISKPKSIKQPSVDKSPDYLVNVISEESIIDEPIPEDYVVTEAAEEKPSEEPTFKVEELETEAVEKEVTDDDKGETTKQSVTKRKIKKLVGPKEEIIEIVETKTGDTPEYEVIVTTEEVQEKSKEAPEEKKAKTVRKAKKIPKDDLQDYIQKLIEQDIPKTELEKYEKIDLDEPVKMKRKPIKKVKQSEEQPKEETEEPIEDKPVEKISEYSEVDSDEPKLTVAVKEFIPEKPEEKPFEIVVLEETVESKREPDEEGKVREKVVKTKKIKQNRGSVEVVHDIVEEIDTDTNESVITVTTTVPTETPDQDQPSVKQKRTKKIKKDEVEDFVKRVIEEEAPQPEGSVDLVVIEDFVPKPSSEKRKKKPIKDKHTSVEEETPHEDEVLLIESVPEDSPLSDDLITVVDSVPIEEEPENKVNQIEDTKKPEKKKKPKPSAKILEENVPEDTVEKPLEALHTDSDLEKPDVQEFSISIKEEEQKHTHPEKKKSSKISSEQPKQPSTEQYEISVTEHDLKPEEEKPFTVQVIQSETNVEETKDDTGKVHKQVTTKRMLRRPAGEGEIEIIEVVRDDQPEAEITIVEYEPEPVNQDEKPKEPKKKTRKVKKDDIHDYIQKLIELETPKTELEKYEKIEFEPIVKDKPLDSPIDVLDESPKEVQKKDKKSRSTKVPNEETPVQEQYAKVNVVEEEAPEQPEIPVQILEVKPVEVDVKEVITEDGKPVQEKTTKRVLKKIGPEEQTTFKITMIESEDNDSVTVIVDEEPEIASPQSIEEHPEQSKEKLAPKPKKTVRKVKKDDLSDYVKKLIEEEIPKVDLEKYEKVEMPEKPVKLTVSDSIPEEPKPDKSQPISVLPDTTKPKKTKTPKTPKTEDTDQQVPDEPTETTVDTTDIPELTPTQTAQPEDTATAQITPSAQEEKSTQDDTKDTIQKTVKHKKTKPDTQKSVETSELPEVHKDYQISIIHEELVEEEQPEKILEVRVIDEVAEVEESQPIVEEVEDEEPQPATEETVEDVTKPKSKKKKVVKKKTDDHDELIKKMLEQEIEKTELEKYEKIEFDVPKKLKPEFAALEPIKIERKEQKPTKVTILDATDVPKTVKLKPSKRKEKPAEELTVQLPKFRLKARMVLVEYPPAPLIPKTTDIGAIKDNGELSRNIEEAEEILKFKPHKTKKIKKIKDDLEKVELEKYEKYISSEEEPEEKTPYKKPEKAPKPEEKQEDVKLKLGKGKKKPKEEEAPENVTLKNIPQKPQEVEEEVELKQKPKEVEIVEEQTKKPKDGEFVVEPFEPSEFDRPEYVPDELEQIEHPEIPEKVKKPSKTKYKPKDKSKSEPETIVSEIVAGVPKEEEAIPEQDVKFRKPERDAPEETDSEIKLRPVPQASKDENPDEQALVTPKAEEPIPQEIEDKAIDDEKKPKKSKPKKVQPKEQEIAKEEPEEFEVSVKEEEALVDKPIEIEKPKDVKVKEKKPKEAPVSEVVVIEEEPKPEEVPEEIPVEYKITTTVLEPEDAPKEHQVKVIDFDERQETTEEVIEEKVVTRKKKPKPQQPEEFEVTLKEPKEEQIQPDVVSAEISLPIEEPEQKPEQYEVELKITQTTPEEPNDVQIAVKEKVKTKPVKKVKEDKIVVVEAEEEKQPVEETIVEVEKQEEKKKSEKPKSYEFKISETQSIEEKPIEVAEEAPEETPKVVEKKVAEKFDSYEFTLKETDEEKVITVDDQPEEEAPVEVVFKKKPKEPEAVEAEFVMTEPKIVEETSVETAIKQKKTKKPKKDEEEAQLAIKVVESEAPVAEEVFSEAPESKIVEEEVIAEEKPKEFTIRVSESEPKPEEPSVEQFTVKKRKPSVTFADEPATEIVIKESKPAEVVTEDAHIKTKKPKKKVTDVEAEELKIKITEEVPQEIPILEEVSEEEVITETKKTAPVVEEKTYKIGIKETEPEKPAEAIVEEEEPVVTEPIEEAPKPEVFEEHKVRVIEETPRELVEEVIEEEVKVIRRKKPKPEIKEEPEAEVTVSTPKPVEEVEATSSIAVIPEQPTEEEAADLKITIIEEETPPQELVQEIEEIEIVEEPKAPEEQPTDFTFATKDSEKKPTVEELPEEQVTIQKKKKKAPVPEVVEEPEAEFLVKPKTPVQEVTEEAKITKSKKPVKEEEAAAELKVTITEEIPTEPEVQEIIEEIEEIEEEKPAEYVIEVKESQPEAVEDKEVSLPKKKPKAPIVEEPEAEITLKPKVKSEEVQEEAKIVKKKPKKIDEVAVADELTVKVEEEVVPEPIVEEEVIEEFEIKKKPKEPEPEDIVDAAIVKLKKPEPVDADEVVAEVTLKPKAKTEVTEEEFSVDVKLPKEKKERPVEIEEEEIIEEAVVIRKKPKKPFEPTVEDLEETEFSLSFKKPHTINEGVEEAATVLKKRPVKPTTLDEAAAELSIKRQEEEYEEGEDIEEFVVSQQRKPKPLQITEEDEEAYTVKKLKRRKQVDIPEYADVENVTFRARSTKTKEDVDQEFNIALDSYAEEEISMSGKVKLKKPIKKTFSEAADEAKIKIIQDFDDGEEPIIEEIRDDEDTIDEVEEPEEYFVEELPPDEVDFKLKPKKHPKPAYSVQDEEEEQFLIGIRHPKRDSVTYDEDSLTFKKKRKVVQQLFNEDGASLNITREMNVEESENLNIMYSICNYIADNNEAINLVEGEKVTVVGRHSSEWWYVKKSTTEEEGWVPAQYLMEPEEYAQYVQNKLHEKIDKLPVFERPGPEDKPIAPRFIEKLQPIHTPDGYTVQFECKVEGNPRPQIAWFRETAIIKPSQDFQMFYDDDNVATLIIREVFPEDAGQFTVVAKNAAGFTSSTTELIVESPLSDHGSDATALSRRSMSRESSLADILEGIPPTFSKKPKAQYVDENTNVILECRLVAVPEPDIVWTFNGEDIDEEEIKNVRIVTESDMHMYCSVVHISKVKKSQEGTYEVIATNREGEARLPITLKVRTTDKEAPQILEPLRNMVIREGESVVLSTQIVGNPPPKVTWYKDGKPVKNAKSDKDLHTLTLITPQKSEKGEYTVKAVNPLGSVETTANLTIEEPAGGNAEPPLFVERFEEQNVPQKGEIRLPAKVSGNPVPEVQWLFNNTPLFPSERIQQVYDGENIELIIKDANPETDSGDYKCIASNPIGKTSHGARVIVEVDEVTFTKKLKKTITIEEVQSLTLECETSHVVTTKWFFNGKELSGMDHRVVVEDGKTHKLVIRNTNLRDSGTYTCKVKKQETQSTVEVLQRKPDFIKVLEDYEVTEKDTAILDVELTTEATEVTWYKDGEKITPENKNVEFIKDGKARRLVIRDVTIHDEGQYTCKIEGQECSCELVVIELPPEIVEPLNDVAVTKGENAVFEVELSKGDALVKWFKNGKEIVFNERIQLAIDGKKQSLRIVKAKPEDVGEYSVQVGEQTSKAKLTVEEPLVDFVIRLPDITLATKTTDAEFTVQLSQPDVEVTWCKKGKPIKPNQKHEVFVEGTVRRLVIHDASDEDAGEISCVAENVTSSTKLCVEELKLPPVITSDKDQTIKVKENDDVTFTVKYTGVPTPEACWTTRKVVIPKSKRTIPTIDEQSAKLTIKKVVDDDEGEYTVKLVNPVGEAEASLHLVIMRKPTAPGTPQPLEIMHDSITLYWKAPEDDGKSEIIEYILEYQDVKEEKWTEIRKIKDTTYTISKLKIDTEYVFRSIAVNEVGPSPPSPLSPPIRLVPKVETKAPSVQEPLQDVVSELDKEVTLSCVFGGIPEPKVTWKKNGQVFESRSIRYENRVAKYTIEKTTIETEATYTCVATNEKGSAETSCRLKLQQKPVLEVEDKYLTQKLRTGSILTIPATVRGYPQPTVTWHKETIEQKTTKSVTIETTETTSTYTVKKVTREQSGKYKVTATNESGTTYVECTVQVIDKPSRPQSLEIKDIKKDSIVLEWTPPVDDGGLDIEKYTLEKCDVQNNVWMKVSDFNKDIKSYAVQKLSMNAQYMFRVVAANPIGESEPTESDPVTITKKFEKPSPPRGPTTVSGMNDTSFNLAWEPSETDGGSKIIEYIVEIREETETTYRSVGVTLGTVTNIHVEKVVRNKGYFFRIYARNEVGTSEAFETTEKIVLGRKITPPSPPQNLRAPDVTSRSVTLDWEVPARNGGSEITGYCVEKRSSTSTNWTKVITLDAHQLHYTIDNLKEKCEYWFRVSAENEVGLGAPAVTESISLKTHASEFILVVRNCGSYTEFGFLKAVPSPPTGPLEARVLAANAHIFEWGLPESDGGAPLLGYHIAIRDMKKTMWIEVGRVPAGVLKFQIRDLQENHEYMIRIFAKNEIGLSEPLESEEPYKAMTAGHESLPDEPRTEMSSCNTSSWLRDHHMDADIHSYARGRLLQRDEYFFRLWAELPKSKKKKSSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
742	Phosphorylation	SRYQRTESIDEQLNQ	34.42	28490779
2617	Phosphorylation	PEMFVDSTPQQAPVF	22.20	27794539
2985	Phosphorylation	TSTTIFCSSKENIIE	33.42	27794539
2986	Phosphorylation	STTIFCSSKENIIES	56.51	27794539
3012	Phosphorylation	QIQDLEDSLRKDGSK	22.24	27794539
3352	Phosphorylation	GEDVTRASLKCASKS	25.68	27794539
4168	Phosphorylation	VEVIARNSVGESIAT	26.41	27794539
4194	Phosphorylation	YRNVLKNSPRPWYDY	22.24	27794539
4249	Phosphorylation	PKQYKPPTPDWQQNV	42.27	27794539
4308	Phosphorylation	QAKGMAQSYEENLQE	25.60	27794539
4865	Phosphorylation	KPKVRSKSLQPATKV	33.22	27794539
5025	Phosphorylation	KEIQRLKSMESVEIM	32.16	27794539
5028	Phosphorylation	QRLKSMESVEIMEMT	19.19	27794539
5693	Phosphorylation	EQPEEEISPEEEVPQ	29.55	27794539
5730	Phosphorylation	PKLTQQVTEEETPHE	33.08	27794539
6010	Phosphorylation	SEAEQPETPETEFEV	32.86	27794539
6283	Phosphorylation	VPEEKPESEEEELEL	59.85	27794539
6320	Phosphorylation	KPKLKKATPSVDEVS	25.61	27794539
6322	Phosphorylation	KLKKATPSVDEVSEE	37.53	27794539
6327	Phosphorylation	TPSVDEVSEEVAEPF	26.45	27794539
6392	Phosphorylation	TKRLKEASVEGQPQL	23.07	27794539
6414	Phosphorylation	IEKVDEISQEISQKT	21.51	27794539
6418	Phosphorylation	DEISQEISQKTITLL	25.52	27794539
7048	Phosphorylation	DSEITGLTGSEEDLL	39.75	27794539
7050	Phosphorylation	EITGLTGSEEDLLDR	32.36	27794539
7060	Phosphorylation	DLLDRTLSIDEQAPK	27.64	27794539
7280	Phosphorylation	RAKFDISSTSTIVEE	27.06	27794539
7307	Phosphorylation	KKTMVKRSGASESQN	32.75	27794539
8021	Phosphorylation	SSTADSHSPIAEDLP	23.19	27794539
8675	Phosphorylation	KVSNKCASPNIDHLY	28.13	27794539
8945	Phosphorylation	PVFDKELSIPTVSPL	27.84	27794539
10921 (in isoform 3)	Phosphorylation	-	33.81	27794539
11626	Phosphorylation	KSRAFKKSLDDDLDE		27794539
11728	Phosphorylation	ISLIRVVSDENIADI		28490779
12023	Phosphorylation	ADLGAYESDHSDKSN		27794539
12026	Phosphorylation	GAYESDHSDKSNKEL		27794539
12029	Phosphorylation	ESDHSDKSNKELLHP		27794539
14417	Phosphorylation	VKDKPLDSPIDVLDE		27794539
14713	Phosphorylation	TKPDTQKSVETSELP		27794539
14797	Phosphorylation	KKVVKKKTDDHDELI		27794539
14960	Phosphorylation	EKYEKYISSEEEPEE		28490779
14961	Phosphorylation	KYEKYISSEEEPEEK		28490779
15146	Phosphorylation	LRPVPQASKDENPDE		27794539
15356	Phosphorylation	YEVELKITQTTPEEP		27794539
15359	Phosphorylation	ELKITQTTPEEPNDV		27794539
15428	Phosphorylation	YEFKISETQSIEEKP		27794539
15430	Phosphorylation	FKISETQSIEEKPIE		27794539
15603	Phosphorylation	TVKKRKPSVTFADEP		28490779
15605	Phosphorylation	KKRKPSVTFADEPAT		28490779
15667	Phosphorylation	IPILEEVSEEEVITE		28490779
15673	Phosphorylation	VSEEEVITETKKTAP		28490779
15675	Phosphorylation	EEEVITETKKTAPVV		28490779
15886	Phosphorylation	EFLVKPKTPVQEVTE		27794539
16106 (in isoform 5)	Phosphorylation	-		27794539
16369	Phosphorylation	IRHPKRDSVTYDEDS		27794539
16600	Phosphorylation	SPLSDHGSDATALSR		28490779
16614	Phosphorylation	RRSMSRESSLADILE		28490779
16615	Phosphorylation	RSMSRESSLADILEG		28490779
17520	Phosphorylation	FESRSIRYENRVAKY		27794539
17527	Phosphorylation	YENRVAKYTIEKTTI		27794539
17528	Phosphorylation	ENRVAKYTIEKTTIE		27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TITIN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TITIN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TITIN_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of TITIN_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.